Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Daniela M. Tomazela"'
Publikováno v:
mAbs
Characterization of charge heterogeneity in monoclonal antibodies (mAbs) is needed during developability assessment and downstream development of drug candidates. Charge heterogeneity can come from post-translational modifications like deamidation, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9440c5a6c531f5d0fb0f88a461fafa27
http://europepmc.org/articles/PMC7299211
http://europepmc.org/articles/PMC7299211
Autor:
Huiping Ma, SuChun Hseih, Shuli Zhang, Gulesi Ayanoglu, Christina Moon, Svetlana Antonenko, Damien Bresson, Isabel Figueroa, Eric Rimmer, Enrique Escandón, Edward Hsieh, Maribel Beaumont, Anthony Manibusan, Franklin Vives, Grigori Ermakov, Daniela M. Tomazela, Jennifer H. Yearley, Andrew H. Beck, Wondwessen Mengesha, Yaoli Song, On-Yee So, Divas Neupane, Michael Judo, Douglas Hodges, Yi Wei Zhang, Dennis Gately, Xiaoyan Du, Nick Knudsen
Publikováno v:
AAPS Open, Vol 4, Iss 1, Pp 1-17 (2018)
Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic or antagonistic responses, tunable effector function, and optimal pharmacokinetic properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd018dbd2cdf16eeb7c9cfacdd32e689
https://doi.org/10.1186/s41120-018-0026-0
https://doi.org/10.1186/s41120-018-0026-0
Autor:
Juhi Firdos, Kern Jeffrey, Dennis M. Zaller, Douglas Hodges, Laurence Fayadat-Dilman, Isabel Figueroa, Shuli Zhang, Anthony Manibusan, Peter Stivers, Lily Y. Moy, Hyun Chong Woo, Yiwei Zhang, Nickolas Knudsen, Philip E. Brandish, Laura Garvin-Queen, Svetlana Antonenko, Kristen Kwasnjuk, Daniela M. Tomazela, Prasanthi Geda, SuChun Hseih, Mark T. Cancilla, Sanjiv J. Shah, Robert M. Garbaccio, Maribel Beaumont, John H. Shin, Lia Benso, Dennis Gately, Huiping Ma, Christopher Haines, Mangeng Cheng, Paul L. Miller, Mark Zielstorff, Linda Liang, Anthony Palmieri, Ying Sun, Guo Feng, Yujie Qu
Publikováno v:
Bioconjugate chemistry. 29(7)
Glucocorticoids (GCs) are excellent anti-inflammatory drugs but are dose-limited by on-target toxicity. We sought to solve this problem by delivering GCs to immune cells with antibody-drug conjugates (ADCs) using antibodies containing site-specific i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7229ec9a33f21a3683f44ccad95f70dc
https://pubmed.ncbi.nlm.nih.gov/29923706
https://pubmed.ncbi.nlm.nih.gov/29923706
Autor:
Maribel Beaumont, Kerry L. Fillgrove, Kevin P. Bateman, Scott Fauty, Qian Zhang, Daniela M. Tomazela, Jane Harrelson, Jacqueline Kenny, Lisa A Vasicek, BaoJen Shyong, Daniel S. Spellman
Publikováno v:
Bioanalysis. 8(7)
Aim: Reduce animal usage for discovery-stage PK studies for biologics programs using microsampling-based approaches and microscale LC–MS. Methods & results: We report the development of an automated DBS-based serial microsampling approach for study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a276702070a0b7c2aff9149a6be2fb
https://pubmed.ncbi.nlm.nih.gov/26977979
https://pubmed.ncbi.nlm.nih.gov/26977979
Autor:
Daniela M. Tomazela, Juhi Firdos, Damien Bresson, Anthony Manibusan, Dennis Gately, Philip E. Brandish, Guo Feng, Isabel Figueroa, Anthony Palmieri, Nick Knudsen, Maribel Beaumont, Mangeng Cheng, Robert M. Garbaccio, SuChun Hsieh, Peter Stivers, Deborah Dooney, Prasanthi Geda, Kern Jeffrey, Jeffrey Zhang, Andrew H. Beck, Ying Sun, Linda Liang, Rena Zhang, Mark T. Cancilla, Sanjiv J. Shah, Kristen Kwasnjuk, Peter G. Schultz
Publikováno v:
Journal of the American Chemical Society. 138(4)
As part of an effort to examine the utility of antibody-drug conjugates (ADCs) beyond oncology indications, a novel pyrophosphate ester linker was discovered to enable the targeted delivery of glucocorticoids. As small molecules, these highly soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359a1458b0a0113506216f270d1a0b00
https://pubmed.ncbi.nlm.nih.gov/26745435
https://pubmed.ncbi.nlm.nih.gov/26745435
Autor:
Aaron Hamvas, Michael S. Bereman, Hillary S. Heins, F. Sessions Cole, Michael J. MacCoss, Paola Cogo, Bruce W. Patterson, Manuela Simonato, Daniela M. Tomazela
Publikováno v:
Analytical and Bioanalytical Chemistry. 403:2397-2402
We report a method to measure in vivo turnover of four proteins from sequential tracheal aspirates obtained from human newborn infants with respiratory distress syndrome using targeted proteomics. We detected enrichment for all targeted proteins appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b27fa1eec55f9fe2fe951fb3d77d55
https://doi.org/10.1007/s00216-012-5953-3
https://doi.org/10.1007/s00216-012-5953-3
Autor:
Steven A. Carr, Susan E. Abbatiello, Michael J. MacCoss, Brendan MacLean, Shucha Zhang, Jeffrey R. Whiteaker, Daniela M. Tomazela, Amanda G. Paulovich
Publikováno v:
Analytical Chemistry. 82:10116-10124
Proteomics experiments based on Selected Reaction Monitoring (SRM, also referred to as Multiple Reaction Monitoring or MRM) are being used to target large numbers of protein candidates in complex mixtures. At present, instrument parameters are often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f2a5e08e8d1df263fc9d12598b716b
https://doi.org/10.1021/ac102179j
https://doi.org/10.1021/ac102179j
Publikováno v:
Journal of Proteome Research. 9:5209-5216
Accurate predictions of peptide retention times (RT) in liquid chromatography have many applications in mass spectrometry-based proteomics. Most notably such predictions are used to weed out incorrect peptide-spectrum matches, and to design targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5079a78b0b89739d804e842f5eb64033
https://doi.org/10.1021/pr1005058
https://doi.org/10.1021/pr1005058
Autor:
F. Sessions Cole, Paolo Vicini, Kimberly Spence, Daniela M. Tomazela, Elizabeth Hanson, Bruce W. Patterson, Aaron Hamvas, David H. Salinger, Tiffany B. Kanion, Hugh Barret, Hillary B. Heins, Michael J. MacCoss
Publikováno v:
Analytical Chemistry. 82:2561-2567
We describe a method to measure protein synthesis and catabolism in humans without prior purification and use the method to measure the turnover of surfactant protein-B (SP-B). SP-B, a lung-specific, hydrophobic protein essential for fetal-neonatal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cdf3a36caed40efcd0c5635cfaf8cf
https://doi.org/10.1021/ac1001433
https://doi.org/10.1021/ac1001433
Publikováno v:
Transition Metal Chemistry. 33:1059-1065
The polymetallic [Ru3O(CH3COO)6(py)2(BPE)Ru(bpy)2Cl](PF6)2 complex (bpy = 2,2′-bipyridine, BPE = trans-1,2-bis(4-pyridil)ethylene and py = pyridine) was assembled by the combination of an electroactive [Ru3O] moiety with a [Ru(bpy)2(BPE)Cl] photoac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f7a293446e03a4e0cb292fbe04f70ce
https://doi.org/10.1007/s11243-008-9156-x
https://doi.org/10.1007/s11243-008-9156-x