Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniela Lenz"'
Autor:
Lucas Lange, Dirk Hoffmann, Adrian Schwarzer, Teng-Cheong Ha, Friederike Philipp, Daniela Lenz, Michael Morgan, Axel Schambach
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 122-137 (2020)
Summary: Induced pluripotent stem cells (iPSCs) offer a promising platform to model early embryonic developmental processes, to create disease models that can be evaluated by drug screens as well as proof-of-concept experiments for regenerative medic
Externí odkaz:
https://doaj.org/article/6d42135a779e40799f8fcbee24bcd545
Autor:
Daniela Paasch, Johann Meyer, Andriana Stamopoulou, Daniela Lenz, Johannes Kuehle, Doreen Kloos, Theresa Buchegger, Astrid Holzinger, Christine S. Falk, Christina Kloth, Constantin S. von Kaisenberg, Hinrich Abken, Axel Schambach, Nico Lachmann, Michael Morgan, Thomas Moritz
Publikováno v:
Cells, Vol 11, Iss 6, p 994 (2022)
Chimeric antigen receptor (CAR) T-cell therapies have shown impressive results in patients with hematological malignancies; however, little success has been achieved in the treatment of solid tumors. Recently, macrophages (MΦs) were identified as an
Externí odkaz:
https://doaj.org/article/43d3b295b9ed4b2f841abfe2582e903a
Autor:
Michael A. Morgan, Arnold Kloos, Daniela Lenz, Nadine Kattre, Juliette Nowak, Marco Bentele, Maximilian Keisker, Julia Dahlke, Katharina Zimmermann, Martin Sauer, Michael Heuser, Axel Schambach
Publikováno v:
Viruses, Vol 13, Iss 7, p 1365 (2021)
Anti-cancer activity can be improved by engineering immune cells to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens. Retroviral vector gene transfer strategies allow stable and durable transgene expression. Here, we
Externí odkaz:
https://doaj.org/article/48425720398c406f87d49f3ef686e77d
Autor:
Julia Skokowa, Dirk Hoffmann, Nico Lachmann, Daniela Zychlinski, Friederike Philipp, Daniela Lenz, Thomas Moritz, Axel Schambach, Doris Steinemann, Johannes Kuehle, Michael A. Morgan, Christoph Klein
Publikováno v:
Gene Therapy. 27:297-306
Induced pluripotent stem cells (iPSCs) from patients with genetic disorders are a valuable source for in vitro disease models, which enable drug testing and validation of gene and cell therapies. We generated iPSCs from a severe congenital neutropeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c338bc14eca2b193b90c3edbf1c31391
https://doi.org/10.1038/s41434-020-0127-y
https://doi.org/10.1038/s41434-020-0127-y
Autor:
Katharina Zimmermann, Nadine Kattre, Axel Schambach, Michael Heuser, Daniela Lenz, Arnold Kloos, Juliette Nowak, Marco Bentele, Maximilian Keisker, Julia Dahlke, Michael A. Morgan, Martin Sauer
Publikováno v:
Viruses, Vol 13, Iss 1365, p 1365 (2021)
Viruses
Volume 13
Issue 7
Viruses
Volume 13
Issue 7
Anti-cancer activity can be improved by engineering immune cells to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens. Retroviral vector gene transfer strategies allow stable and durable transgene expression. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef70ad3f0cdc57b6d33568208fa1be1
https://www.mdpi.com/1999-4915/13/7/1365
https://www.mdpi.com/1999-4915/13/7/1365
Autor:
Theresa Buchegger, Daniel Brand, Friederike Philipp, Christine S. Falk, Philippe Vollmer Barbosa, Doris Steinemann, Daniela Lenz, Dirk Hoffmann, Sebastian Brennig, Axel Schambach, Nico Lachmann, Johanna Sens, Michael A. Morgan, Christoph Klein, Johannes Kuehle
Publikováno v:
Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 221, p 221 (2021)
Volume 11
Issue 3
Journal of Personalized Medicine, Vol 11, Iss 221, p 221 (2021)
Volume 11
Issue 3
Patient material from rare diseases such as very early-onset inflammatory bowel disease (VEO-IBD) is often limited. The use of patient-derived induced pluripotent stem cells (iPSCs) for disease modeling is a promising approach to investigate disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c2f822e7a5afe92600d1379c84bc6d
Autor:
Dirk Hoffmann, Axel Schambach, Friederike Philipp, Teng-Cheong Ha, Adrian Schwarzer, Lucas Lange, Michael A. Morgan, Daniela Lenz
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 14, Iss 1, Pp 122-137 (2020)
Stem Cell Reports, Vol 14, Iss 1, Pp 122-137 (2020)
Summary Induced pluripotent stem cells (iPSCs) offer a promising platform to model early embryonic developmental processes, to create disease models that can be evaluated by drug screens as well as proof-of-concept experiments for regenerative medici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97ead3dc9c1c1cb633ed7a6c3466f30
Autor:
Dirk, Hoffmann, Johannes, Kuehle, Daniela, Lenz, Friederike, Philipp, Daniela, Zychlinski, Nico, Lachmann, Thomas, Moritz, Doris, Steinemann, Michael, Morgan, Julia, Skokowa, Christoph, Klein, Axel, Schambach
Publikováno v:
Gene therapy. 27(6)
Induced pluripotent stem cells (iPSCs) from patients with genetic disorders are a valuable source for in vitro disease models, which enable drug testing and validation of gene and cell therapies. We generated iPSCs from a severe congenital neutropeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32aa0571a45ba7050fa2084ae5cd63d2
https://pubmed.ncbi.nlm.nih.gov/32051561
https://pubmed.ncbi.nlm.nih.gov/32051561
Autor:
Axel Schambach, Dirk Hoffmann, Juliane W. Schott, Lucas Lange, Doris Steinemann, Michael A. Morgan, Franz-Josef Müller, Daniela Lenz, Thomas Moritz, Franziska K. Geis, Daniela Zychlinski
Publikováno v:
Gene therapy. 24(5)
Correction of patient-specific induced pluripotent stem cells (iPSC) upon gene delivery through retroviral vectors offers new treatment perspectives for monogenetic diseases. Gene-modified iPSC clones can be screened for safe integration sites and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a5dcf3d77ec2ed001fcf539f19a5d9
https://pubmed.ncbi.nlm.nih.gov/28346436
https://pubmed.ncbi.nlm.nih.gov/28346436
Autor:
J. Marienhagen, Andreas Hehr, G. Uyanik, Joachim Weis, Ulrich Bogdahn, Haluk Topaloglu, Daniela Lenz, Josep Gamez, Bernhard H. F. Weber, Olaf Riess, Peter Bauer, Beate Winner, Thomas M. Ringer, Ute Hehr, Michael Bonin, Juergen Winkler, Akguen Olmez, Ludger Schöls, Anna Engel, Sonja Ploetz, Wolfgang Koehler, Gerhard Schuierer, Arndt Rolfs, Andrea Seibel, Rebecca Schüle
Publikováno v:
Annals of Neurology. 62:656-665
Objective: Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of neurodegenerative disorders resulting in progressive spasticity of the lower limbs. One form of autosomal recessive hereditary spastic paraplegia (ARHSP) with thin cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceba5e294ad67956caea04e927efee3
https://doi.org/10.1002/ana.21310
https://doi.org/10.1002/ana.21310