Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Daniela Lecca"'
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106563- (2024)
Externí odkaz:
https://doaj.org/article/4a8fdaad6d87422b91427c0a069d7f0b
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-25 (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Autor:
Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-21 (2023)
Abstract Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved dr
Externí odkaz:
https://doaj.org/article/7c5613a4803945af9101f28f707d2991
Autor:
Shih Chang Hsueh, Michael T. Scerba, David Tweedie, Daniela Lecca, Dong Seok Kim, Abdul Mannan Baig, Yu Kyung Kim, Inho Hwang, Sun Kim, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2449 (2022)
Traumatic brain injury (TBI) is a major risk factor for several neurodegenerative disorders, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Neuroinflammation is a cause of later secondary cell death following TBI, has the potent
Externí odkaz:
https://doaj.org/article/7363abdad1cd4e2f96aeea1e980c087f
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 439-453 (2019)
Traumatic brain injury (TBI) is a neurodegenerative disorder for which no effective pharmacological treatment is available. Glucagon-like peptide 1 (GLP-1) analogues such as Exenatide have previously demonstrated neurotrophic and neuroprotective effe
Externí odkaz:
https://doaj.org/article/ed22acdb854b481d8687b470984eeda5
Autor:
Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen, John Chung-Che Wu, Jia-Yi Wang, Yi-Syue Tsou, Inho Hwang, Yukyung Kim, Dayeon Gil, Eui Jung Jo, Baek-Soo Han, David Tweedie, Daniela Lecca, Michael T. Scerba, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig, Yung-Hsiao Chiang
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 950 (2022)
(1) Background: An important concomitant of stroke is neuroinflammation. Pomalidomide, a clinically available immunomodulatory imide drug (IMiD) used in cancer therapy, lowers TNF-α generation and thus has potent anti-inflammatory actions. Well-tole
Externí odkaz:
https://doaj.org/article/abe37d4afed640b4839048006b4ded35
Autor:
Chih-Tung Lin, Daniela Lecca, Ling-Yu Yang, Weiming Luo, Michael T Scerba, David Tweedie, Pen-Sen Huang, Yoo-Jin Jung, Dong Seok Kim, Chih-Hao Yang, Barry J Hoffer, Jia-Yi Wang, Nigel H Greig
Publikováno v:
eLife, Vol 9 (2020)
Traumatic brain injury (TBI) causes mortality and disability worldwide. It can initiate acute cell death followed by secondary injury induced by microglial activation, oxidative stress, inflammation and autophagy in brain tissue, resulting in cogniti
Externí odkaz:
https://doaj.org/article/3c2e1f55fd3a4ffd8982901f2fa50dfe
Autor:
Daniela Lecca, Miaad Bader, David Tweedie, Alexander F. Hoffman, Yoo Jin Jung, Shin-Chang Hsueh, Barry J. Hoffer, Robert E. Becker, Chaim G. Pick, Carl R. Lupica, Nigel H. Greig
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104528- (2019)
Mild traumatic brain injury (mTBI) is a risk factor for neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). TBI-derived neuropathologies are promoted by inflammatory processes: chronic microgliosis and release
Externí odkaz:
https://doaj.org/article/ec8d1f8e8b1749de8bc7867330abc497
Autor:
Shih-Chang Hsueh, Daniela Lecca, Nigel H. Greig, Jia-Yi Wang, Warren Selman, Barry J. Hoffer, Jonathan P. Miller, Yung-Hsiao Chiang
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited treatment options. We have previously shown that (-)-phenserine (Phen), an acetylcholinesterase inhibitor originally designed an
Externí odkaz:
https://doaj.org/article/b2324a6a70c7428890dc11f2aabd8f1d
Autor:
Augusta Pisanu, Daniela Lecca, Giovanna Mulas, Jadwiga Wardas, Gabriella Simbula, Saturnino Spiga, Anna R. Carta
Publikováno v:
Neurobiology of Disease, Vol 71, Iss , Pp 280-291 (2014)
Neuroinflammatory changes play a pivotal role in the progression of Parkinson's disease (PD) pathogenesis. Recent findings have suggested that activated microglia may polarize similarly to peripheral macrophages in the central nervous system (CNS), a
Externí odkaz:
https://doaj.org/article/26c53dd6b1084ddea4d92e08241c582c