Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniela Langenhorst"'
Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
Autor:
Luke D. Halder, Svitlana Babych, Diana I. Palme, Elham Mansouri-Ghahnavieh, Lia Ivanov, Victory Ashonibare, Daniela Langenhorst, Bhupesh Prusty, Günter Rambach, Melissa Wich, Nora Trinks, Matthew G. Blango, Daniel Kornitzer, Ulrich Terpitz, Cornelia Speth, Berit Jungnickel, Niklas Beyersdorf, Peter F. Zipfel, Axel A. Brakhage, Christine Skerka
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT In response to infections, human immune cells release extracellular vesicles (EVs) that carry a situationally adapted cocktail of proteins and nucleic acids, including microRNAs (miRNAs), to coordinate the immune response. In this study, we
Externí odkaz:
https://doaj.org/article/66c93ab97dcd4f169fa55e314a6c98f3
Autor:
Daniela Langenhorst, Stephanie Haack, Selina Göb, Anna Uri, Fred Lühder, Bernard Vanhove, Thomas Hünig, Niklas Beyersdorf
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-
Externí odkaz:
https://doaj.org/article/aa89dd6fa47043779ab56e35c4c363df
Autor:
Daniela Langenhorst, Paula Tabares, Tobias Gulde, Bryan R. Becklund, Susanne Berr, Charles D. Surh, Niklas Beyersdorf, Thomas Hünig
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
In rodents, low doses of CD28-specific superagonistic monoclonal antibodies (CD28 superagonists, CD28SA) selectively activate regulatory T cells (Treg). This observation has recently been extended to humans, suggesting an option for the treatment of
Externí odkaz:
https://doaj.org/article/803c85bb94f64da7b18c609ea251a7cd
Autor:
Daniela Langenhorst, Tea Gogishvili, Eliana Ribechini, Susanne Kneitz, Kirsty McPherson, Manfred B Lutz, Thomas Hünig
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50080 (2012)
The ability of CD4(+)Foxp3(+) regulatory T-cells (Treg) to produce interleukin (IL)-10 is important for the limitation of inflammation at environmental interfaces like colon or lung. Under steady state conditions, however, few Tregs produce IL-10 ex
Externí odkaz:
https://doaj.org/article/f7a2af6b1c8f4353bd0e24cac9e33fbf
Autor:
Tea Gogishvili, Daniela Langenhorst, Fred Lühder, Fernando Elias, Karin Elflein, Kevin M Dennehy, Ralf Gold, Thomas Hünig
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4643 (2009)
Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regulatory T-cells (Treg cells) in rats, but a first-in-man trial of the human CD28SA TGN1412 resulted in an unexpected cytokine release syndrome. Using a
Externí odkaz:
https://doaj.org/article/73967c47d22441d8b9794e66560be981
Autor:
Daniela Langenhorst, Tim Sparwasser, Niklas Beyersdorf, Jan Schlegel, Markus Sauer, Stephanie Haack, Sarah Baiker
Like human Th1 cells, mouse Th1 cells also secrete IFN-γ upon stimulation with a superagonistic anti-CD28 monoclonal antibody (CD28-SA). Crosslinking of the CD28-SA via FcR and CD40-CD40L interactions greatly increased IFN-γ release. Our data stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbeeb31132db69a11b10c1913dd166e6
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-239028
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-239028
Autor:
Hans-Peter Tony, Birgit Sawitzki, Daniela Langenhorst, Ineke J. M. ten Berge, Susanne Berr, Thomas Hünig, Paula Tabares
Publikováno v:
European journal of immunology, 48(2), 366-379. Wiley-VCH Verlag
The identification of regulatory T cells (Treg cells) in human peripheral blood is an important tool in diagnosis, research and therapeutic intervention. As compared to lymphoid tissues, the frequencies of circulating Treg cells identified as CD4+CD2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838e05ae78597ba6aabcb1ef964ae1f7
https://doi.org/10.1002/eji.201747244
https://doi.org/10.1002/eji.201747244
Publikováno v:
European Journal of Immunology. 45:3362-3374
Mice deficient in IL-2 signaling develop severe anemia indicating a defect in erythropoiesis. However, why deficiency in IL-2, an essential growth factor for lymphocytes, or in IL-2 signaling components should result in defective erythropoiesis is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50aa2ef2378a43443cce58033fb1cef5
https://doi.org/10.1002/eji.201545596
https://doi.org/10.1002/eji.201545596
Autor:
Daniela, Langenhorst, Paula, Tabares, Tobias, Gulde, Bryan R, Becklund, Susanne, Berr, Charles D, Surh, Niklas, Beyersdorf, Thomas, Hünig
Publikováno v:
Frontiers in Immunology
In rodents, low doses of CD28-specific superagonistic monoclonal antibodies (CD28 superagonists, CD28SA) selectively activate regulatory T cells (Treg). This observation has recently been extended to humans, suggesting an option for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9d41b10f049bbb5b267bf1c2cd62246
https://pubmed.ncbi.nlm.nih.gov/29441059
https://pubmed.ncbi.nlm.nih.gov/29441059