Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Daniela Kugelmann"'
Autor:
Anna M. Sigmund, Markus Winkler, Sophia Engelmayer, Daniela Kugelmann, Desalegn T. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermair, Mariya Y. Radeva, Franziska C. Bayerbach, Elisabeth Butz, Stefan Kotschi, Christoph Hudemann, Michael Hertl, Sunil Yeruva, Enno Schmidt, Amir S. Yazdi, Kamran Ghoreschi, Franziska Vielmuth, Jens Waschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament anch
Externí odkaz:
https://doaj.org/article/a933bd3a4505443a83704c045d6c6602
Autor:
Daniela Kugelmann, Maresa Anders, Anna M. Sigmund, Desalegn T. Egu, Ramona A. Eichkorn, Amir S. Yazdi, Miklós Sárdy, Michael Hertl, Dario Didona, Takashi Hashimoto, Jens Waschke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The severe autoimmune blistering disease Pemphigus vulgaris (PV) is mainly caused by autoantibodies (IgG) against desmoglein (Dsg) 3 and Dsg1. The mechanisms leading to the development of blisters are not fully understood, but intracellular signaling
Externí odkaz:
https://doaj.org/article/bf9ecf11ae6e48e982490804fb4a2c1c
Autor:
Thomas Schmitt, Julia Pircher, Letyfee Steinert, Katharina Meier, Kamran Ghoreschi, Franziska Vielmuth, Daniela Kugelmann, Jens Waschke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers ha
Externí odkaz:
https://doaj.org/article/b406899fe8ce4df4930d2158cfec3c22
Autor:
Matthias Hiermaier, Daniela Kugelmann, Mariya Y. Radeva, Dario Didona, Kamran Ghoreschi, Solimani Farzan, Michael Hertl, Jens Waschke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The autoimmune dermatosis pemphigus foliaceus (PF) is predominantly caused by IgG autoantibodies against the desmosomal cadherin desmoglein (Dsg) 1. The exact mechanisms that lead to the characteristic epidermal blistering are not yet fully understoo
Externí odkaz:
https://doaj.org/article/56986024b7ab4549b120119c13d7aeca
Autor:
Anna M. Sigmund, Markus Winkler, Sophia Engelmayer, Daniela Kugelmann, Desalegn T. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermaier, Mariya Y. Radeva, Franziska C. Bayerbach, Elisabeth Butz, Stefan Kotschi, Christoph Hudemann, Michael Hertl, Sunil Yeruva, Enno Schmidt, Amir S. Yazdi, Kamran Ghoreschi, Franziska Vielmuth, Jens Waschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/1bce74d7b5764a4e8f7f6dbd99a47975
Autor:
Sunil Yeruva, Ellen Kempf, Desalegn Tadesse Egu, Heinrich Flaswinkel, Daniela Kugelmann, Jens Waschke
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as pos
Externí odkaz:
https://doaj.org/article/d0663833363645b3bf1e7e13a1a676b0
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Desmosomes reinforce cohesion of epithelial cells at the interface between adjacent cells. They include the cadherin-type adhesion molecules desmoglein 1 (Dsg1) and Dsg3. Pemphigus vulgaris (PV) is an autoimmune disease in which circulating autoantib
Externí odkaz:
https://doaj.org/article/54b7894cd1974bd5b6d8d31251bc00cc
Autor:
Hanna Ungewiß, Franziska Vielmuth, Shintaro T. Suzuki, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Daniela Kugelmann, Nicolas Schlegel, Jens Waschke
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Intestinal epithelial barrier properties are maintained by a junctional complex consisting of tight junctions (TJ), adherens junctions (AJ) and desmosomes. Desmoglein 2 (Dsg2), an adhesion molecule of desmosomes and the only Dsg isoform expr
Externí odkaz:
https://doaj.org/article/e3bf6cdb8c36482bbd4222776e21ef8f
Autor:
Daniela Kugelmann, Vera Rötzer, Elias Walter, Desalegn Tadesse Egu, Michael Tobias Fuchs, Franziska Vielmuth, Hilda Vargas-Robles, Michael Schnoor, Michael Hertl, Rüdiger Eming, Klemens Rottner, Ansgar Schmidt, Volker Spindler, Jens Waschke
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). Src was proposed to contribute to loss of keratinocyte cohesion. However, the role and underlying mechanisms are u
Externí odkaz:
https://doaj.org/article/ebacc96b80ad43a2a0d3b919c2e0a6d9
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126213 (2015)
Adducins tightly regulate actin dynamics which is critical for endothelial barrier function. Adducins were reported to regulate epithelial junctional remodeling by controlling the assembly of actin filaments at areas of cell-cell contact. Here, we in
Externí odkaz:
https://doaj.org/article/d33c2c260c4449b7bd22bf784056d244