Výsledky vyhledávání - "Daniela Kostanova-Poliakova"

Akademický článek

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells

Autor: Miriam Wöhner, Theresa Pinter, Peter Bönelt, Astrid Hagelkruys, Daniela Kostanova-Poliakova, Johannes Stadlmann, Stephen F. Konieczny, Maria Fischer, Markus Jaritz, Meinrad Busslinger

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Antibody secretion by plasma cells provides acute and long-term protection against pathogens. The high secretion potential of plasma cells depends on the unfolded protein response, which is controlled by the transcription factor Xbp1. Here, we analyz

Externí odkaz: https://doaj.org/article/3cc0753e9f5d4decbd571668ede0afff

Zobrazit plný text záznamu

The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation

Autor: Sabine Jurado, Anna S Fedl, Markus Jaritz, Daniela Kostanova‐Poliakova, Stephen G Malin, Charles G Mullighan, Sabine Strehl, Maria Fischer, Meinrad Busslinger

Publikováno v: The EMBO journal. 41(7)

While PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia (B-ALL), it is also involved in oncogenic translocations coding for diverse PAX5 fusion proteins. PAX5-JAK2 encodes a protein consisting of the PAX5 DNA-binding r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e2c9bf2050a70a3f8ba7612cbcf697
https://pubmed.ncbi.nlm.nih.gov/35156727

Zobrazit plný text záznamu

Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells

Autor: Reshma Taneja, Moritz J. Rossner, Meinrad Busslinger, Taras Kreslavsky, Daniela Kostanova Poliakova, Markus Jaritz, Hiromi Tagoh, Bojan Vilagos, Siegfried Weiss, Tanja A. Schwickert, Miriam Wöhner

Publikováno v: Nature Immunology. 18:442-455

Innate-like B-1a cells provide a first line of defense against pathogens, yet little is known about their transcriptional control. Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637c4e206dc32767cc9211c9f63bcbbf
https://doi.org/10.1038/ni.3694

Zobrazit plný text záznamu

Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development

Autor: Meinrad Busslinger, Maria Fischer, Markus Jaritz, Hiromi Tagoh, Daniela Kostanova Poliakova, Ivan Bilic, Miriam Wöhner

Publikováno v: The Journal of Experimental Medicine

Busslinger et al. showed that the transcription factors E2A and E2-2 control the expression of genes required for the development of GC B cells and plasma cells.
E2A is an essential regulator of early B cell development. Here, we have demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f77867411ce837e3f95bc6c52f96663
https://pubmed.ncbi.nlm.nih.gov/27261530

Zobrazit plný text záznamu