Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniela Kenzelmann Broz"'
Autor:
Daniela Kenzelmann Broz, Stephano S. Mello, Pawel K. Mazur, Laura D. Attardi, John L. Rinn, Carolyn Sinow, Hannes Vogel, Julien Sage, Laura D. Wood, Tetsuro Hirose, Jamie F. Conklin Imam, Shinichi Nakagawa, Kathryn T. Bieging-Rolett, Nitin Raj
Publikováno v:
Genes & Development. 31:1095-1108
The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor suppression remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c35d149ea942e063e1614a2871281b4
https://doi.org/10.1101/gad.284661.116
https://doi.org/10.1101/gad.284661.116
Autor:
Laura D. Attardi, Julia T. Garcia, Ashwin Peres-da-Silva, Howard Y. Chang, Kun Qu, Rachel Baum, Adam M. Schmitt, James K. Chen, Shuling Guo, Alexander Y. Payumo, Tiffany Hung, Ying Shen, Ryan A. Flynn, Daniela Kenzelmann Broz
Publikováno v:
Nature genetics
Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA damage response. DNA damage activated transcription of the DINO (Damage Induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c7cbf9d3994ac99568633c59d0eb11
https://doi.org/10.1038/ng.3673
https://doi.org/10.1038/ng.3673
Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage
Publikováno v:
Nucleic Acids Research
The tumor suppressor p53 has been studied extensively as a direct transcriptional activator of protein-coding genes. Recent studies, however, have shed light on novel regulatory functions of p53 within noncoding regions of the genome. Here, we use a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12a6ea27819070551ac84371a4fc784
https://doi.org/10.1093/nar/gkv284
https://doi.org/10.1093/nar/gkv284
Autor:
Dadi Jiang, Arend Sidow, Colleen A. Brady, Stephano S. Mello, Laura D. Attardi, Rachel L. Dusek, Daniela Kenzelmann Broz, Kathryn T. Bieging
Publikováno v:
Genes and Development
The mechanisms by which the p53 tumor suppressor acts remain incompletely understood. To gain new insights into p53 biology we used high throughput sequencing to analyze global p53 transcriptional networks in primary mouse embryo fibroblasts in respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd48222127c91d042afd3b0f17a566ff
Publikováno v:
Carcinogenesis
p53 is a crucial tumor suppressor, as evidenced by the high propensity for p53 mutation during human cancer development. Already more than a decade ago, p53 knockout mice confirmed that p53 is critical for preventing tumorigenesis. More recently, a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913c29e9698df29127939678e648ed42
https://doi.org/10.1093/carcin/bgp331
https://doi.org/10.1093/carcin/bgp331
Autor:
Xavier Estivill, Jordi Clarimón, Pau Pastor, Ruth Chiquet-Ehrismann, Daniela Kenzelmann Broz, Maria Kousi, Hyun Hor, Félix Javier Jiménez-Jiménez, Sara Ortega-Cubero, Stephan Ossowski, Luca Bartesaghi, Ludmila Francescatto, Elena García-Martín, Alexandre Gironell, Roman Chrast, María José Martí, Hortensia Alonso-Navarro, F. Coria, Oswaldo Lorenzo-Betancor, Charlotte N. Hor, Jaume Kulisevsky, Alberto Lleó, José A. G. Agúndez, Nicholas Katsanis, Oliver Drechsel
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
HUMAN MOLECULAR GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Human Molecular Genetics, vol. 24, no. 20, pp. 5677-5686
Consejería de Sanidad de la Comunidad de Madrid
HUMAN MOLECULAR GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Human Molecular Genetics, vol. 24, no. 20, pp. 5677-5686
Essential tremor (ET) is a common movement disorder with an estimated prevalence of 5% of the population aged over 65 years. In spite of intensive efforts, the genetic architecture of ET remains unknown. We used a combination of whole-exome sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a971459bf3b5e66e1decf6a0dadeadf
https://hdl.handle.net/20.500.12530/43632
https://hdl.handle.net/20.500.12530/43632
Publikováno v:
Autophagy
The mechanisms by which the TP53/ TRP53 transcription factor acts as a tumor suppressor remain incompletely understood. To gain new insights into TP53/TRP53 biology we used ChIPseq and RNA seq technologies to define global TRP53 transcriptional netwo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9023f1c612c83abe0a8e0797f909c19c
https://europepmc.org/articles/PMC4026029/
https://europepmc.org/articles/PMC4026029/
Autor:
Hannes Vogel, Daniela Kenzelmann Broz, Stephano S. Mello, Dadi Jiang, Colleen A. Brady, Laura D. Attardi, Eunice J. Park
Publikováno v:
Genetics.
The essential role of p53 in tumor suppression is highlighted by the observations that p53 is mutated in over half of human cancers and that p53-null mice are highly predisposed to developing cancer. Although p53 is thought to suppress cancer by indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb7b0a4e09552fb1f5628f33c51e188a
https://doi.org/10.1158/1538-7445.panca2012-b12
https://doi.org/10.1158/1538-7445.panca2012-b12
Autor:
John L. Rinn, Or Zuk, Ahmad M. Khalil, Daniela Kenzelmann-Broz, Ido Amit, Tyler Jacks, Michal Rabani, Maite Huarte, Aviv Regev, Magdalena J. Koziol, Laura D. Attardi, Manuel Garber, Eric S. Lander, David M. Feldser, Mitchell Guttman
Publikováno v:
Cell. 142(3)
SummaryRecently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646d87522ecfbe110441870d9d4199b6
https://pubmed.ncbi.nlm.nih.gov/20691894
https://pubmed.ncbi.nlm.nih.gov/20691894
Autor:
Petr Broz, Dirk Bumann, Søren Warming, Masahiro Yamamoto, Nura Schürmann, Mathias S. Dick, Nobuhiko Kayagaki, Merone Roose-Girma, Daniela Kenzelmann Broz, Kiyoshi Takeda, Roland F. Dreier, Etienne Meunier
Publikováno v:
NATURE
Lipopolysaccharide from Gram-negative bacteria is sensed in the host cell cytoplasm by a non-canonical inflammasome pathway that ultimately results in caspase-11 activation and cell death. In mouse macrophages, activation of this pathway requires the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc3d476e21c96348e59e963286b61b3