Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

Autor: Daniela Hladik, Ines Höfig, Ursula Oestreicher, Johannes Beckers, Martina Matjanovski, Xuanwen Bao, Harry Scherthan, Michael J. Atkinson, Michael Rosemann

Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2019)

Abstract Background Mesenchymal stem cells (MSCs) are attracting increasing interest for cell-based therapies, making use of both their immuno-modulating and regenerative potential. For such therapeutic applications, a massive in vitro expansion of d

Externí odkaz: https://doaj.org/article/a138cc6125e343d5aba65676b83cc104

Dose-dependent long-term effects of a single radiation event on behaviour and glial cells

Autor: Martin Hrabĕ de Angelis, Jochen Graw, Ute Rößler, Gregor Miller, Daniela M. Vogt Weisenhorn, Horst Zitzelsberger, Marie-Claire Ung, Wolfgang Wurst, Daniel Dragosa, Claudia Dalke, Sabine M. Hölter, Frauke Neff, Lillian Garrett, Daniela Hladik, Florian Wagner, Valentin Leitner

Publikováno v: Int. J. Radiat. Biol. 97, 156-169 (2021)
International journal of radiation biology 97(2), 156-169 (2021). doi:10.1080/09553002.2021.1857455

Purpose: The increasing use of low-dose ionizing radiation in medicine requires a systematic study of its long-term effects on the brain, behaviour and its possible association with neurodegenerative disease vulnerability. Therefore, we analysed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297296c60538e74b7d85958f4b23df61

CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure

Autor: Marie-Claire Ung, Helmut Schlattl, Claudia Dalke, Christine von Toerne, Soile Tapio, Michael J. Atkinson, Ute Rößler, Stefanie M. Hauck, Jochen Graw, Jos Philipp, Daniela Hladik, Omid Azimzadeh

Publikováno v: J. Proteome Res. 19, 337-345 (2020)

The impact of low-dose ionizing radiation (IR) on the human brain has recently attracted attention due to the increased use of IR for diagnostic purposes. The aim of this study was to investigate low-dose radiation response in the hippocampus. Female

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82abc36538e6a34386afbd1489c42aec
https://pubmed.ncbi.nlm.nih.gov/31657930

Combined Treatment with Low-Dose Ionizing Radiation and Ketamine Induces Adverse Changes in CA1 Neuronal Structure in Male Murine Hippocampi

Autor: Soile Tapio, Prabal Subedi, Stefanie Winkler, Sonja Buratovic, Stefanie M. Hauck, Per Eriksson, Christine von Toerne, Michael J. Atkinson, Daniela Hladik, Elenore Samson, Omid Azimzadeh, Bo Stenerlöw, Annette Feuchtinger, Jos Philipp

Publikováno v: Int. J. Mol. Sci. 20:2103 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 23

In children, ketamine sedation is often used during radiological procedures. Combined exposure of ketamine and radiation at doses that alone did not affect learning and memory induced permanent cognitive impairment in mice. The aim of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab32887407e7a5ee01644f5d59a008a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-402388

Effects of ionizing radiation on the mammalian brain

Autor: Daniela Hladik, S. Tapio

Publikováno v: Mutation Research/Reviews in Mutation Research. 770:219-230

Epidemiological studies on the atomic-bomb survivors, cancer survivors and occupational cohorts provide strong evidence for multifaceted damage to brain after ionizing radiation. Radiation-induced late effects may manifest as brain tumors or cognitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e38ecaffb777d74e16cec8a248670f3
https://doi.org/10.1016/j.mrrev.2016.08.003