Výsledky vyhledávání - "Daniela Grapentin"

Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB

Autor: Willhart Knepel, R. Blume, Elke Oetjen, Doris Krause, Anke Eggers, Michael Seeger, Daniela Grapentin

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 367(3)

Cyclosporin A and tacrolimus are important immunosuppressive drugs. They share a diabetogenic action as one of their most serious adverse effects. In a single study, tacrolimus (100 nM) inhibited human insulin gene transcription in the beta-cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d853ac6d3f5e4471fd2efe69e06b610
https://pubmed.ncbi.nlm.nih.gov/12644894

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Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context

Autor: Daniela Grapentin, Elke Oetjen, Willhart Knepel, R. Blume, Markus Schwaninger, Gero Siemann

Publikováno v: Molecular pharmacology. 55(6)

The immunosuppressants cyclosporin A and FK506 (tacrolimus) can block the phosphatase calcineurin, thereby inhibiting gene transcription directed by the cyclic AMP (cAMP)- and calcium-responsive transcription factor, cAMP response element (CRE)-bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3645a13f7e215ad51b0d36b430c3d5
https://pubmed.ncbi.nlm.nih.gov/10347253

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