Discovery of New Microbial Collagenase Inhibitors

Autor: Georgiana Nitulescu, Dragos Paul Mihai, Anca Zanfirescu, Miruna Silvia Stan, Daniela Gradinaru, George Mihai Nitulescu

Publikováno v: Life, Vol 12, Iss 12, p 2114 (2022)

Bacterial virulence factors are mediating bacterial pathogenesis and infectivity. Collagenases are virulence factors secreted by several bacterial stains, such as Clostridium, Bacillus, Vibrio and Pseudomonas. These enzymes are among the most efficie

Externí odkaz: https://doaj.org/article/5a875e1aaf564d4a9bb0d01c8257db19

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study

Autor: Ilya Pinchuk, Daniela Weber, Bastian Kochlik, Wolfgang Stuetz, Olivier Toussaint, Florence Debacq-Chainiaux, Martijn E.T. Dollé, Eugène H.J.M. Jansen, Efstathios S. Gonos, Ewa Sikora, Nicolle Breusing, Daniela Gradinaru, Thilo Sindlinger, María Moreno-Villanueva, Alexander Bürkle, Tilman Grune, Dov Lichtenberg

Publikováno v: Redox Biology, Vol 24, Iss , Pp - (2019)

Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers

Externí odkaz: https://doaj.org/article/ff70642965ad4536859d4f5bd6fdafe0

Validation of protein carbonyl measurement: A multi-centre study

Autor: Edyta Augustyniak, Aisha Adam, Katarzyna Wojdyla, Adelina Rogowska-Wrzesinska, Rachel Willetts, Ayhan Korkmaz, Mustafa Atalay, Daniela Weber, Tilman Grune, Claudia Borsa, Daniela Gradinaru, Ravi Chand Bollineni, Maria Fedorova, Helen R. Griffiths

Publikováno v: Redox Biology, Vol 4, Iss C, Pp 149-157 (2015)

Protein carbonyls are widely analysed as a measure of protein oxidation. Several different methods exist for their determination. A previous study had described orders of magnitude variance that existed when protein carbonyls were analysed in a singl

Externí odkaz: https://doaj.org/article/eb668b4f188a4562a4b2b8d5b8eb4568

Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice

Autor: Anca Zanfirescu, Aurelia Nicoleta Cristea, George Mihai Nitulescu, Bruno Stefan Velescu, Daniela Gradinaru

Publikováno v: Nutrients, Vol 10, Iss 1, p 1 (2017)

Monosodium glutamate (MSG) is a widely used food additive. Although it is generally considered safe, some questions regarding the impact of its use on general health have arisen. Several reports correlate MSG consumption with a series of unwanted rea

Externí odkaz: https://doaj.org/article/72478cd7f1b84bb3993cd0094c94540b

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics

Autor: Laura Kananen, Mikko Hurme, Alexander Bürkle, Maria Moreno-Villanueva, Jürgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dollé, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Härkänen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimäki, Olli T. Raitakari, Olavi Ukkola, Mika Kähönen, Marja Jylhä, Juulia Jylhävä

Publikováno v: GEROSCIENCE
Kananen, L, Hurme, M, Bürkle, A, Moreno-Villanueva, M, Bernhardt, J, Debacq-Chainiaux, F, Grubeck-Loebenstein, B, Malavolta, M, Basso, A, Piacenza, F, Collino, S, Gonos, E S, Sikora, E, Gradinaru, D, Jansen, E H J M, Dollé, M E T, Salmon, M, Stuetz, W, Weber, D, Grune, T, Breusing, N, Simm, A, Capri, M, Franceschi, C, Slagboom, E, Talbot, D, Libert, C, Raitanen, J, Koskinen, S, Härkänen, T, Stenholm, S, Ala-Korpela, M, Lehtimäki, T, Raitakari, O T, Ukkola, O, Kähönen, M, Jylhä, M & Jylhävä, J 2022, ' Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics ', GeroScience, vol. 45, no. 1, pp. 85-103 . https://doi.org/10.1007/s11357-022-00590-8

Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes and metabolic processes that lead to elevated cf-DNA levels. We so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1937b684e94cf6fd814da6a2766df5
https://biblio.ugent.be/publication/01H3MEVG6Y0Y2FEYN73BRTMM0J/file/01H3MEYCVHDKPXJFS8FDX6YT26