Relationships between Serum Biomarkers of Oxidative Stress and Tobacco Smoke Exposure in Patients with Mental Disorders

Autor: Ana-Maria Vlasceanu, Daniela Gradinaru, Miriana Stan, Viorela G. Nitescu, Daniela Luiza Baconi

Publikováno v: Antioxidants, Vol 12, Iss 6, p 1299 (2023)

The role of cigarette smoking as an aggravating factor of systemic oxidative stress in patients with mental disorders has not been extensively investigated, although significantly higher rates of smoking are recorded in these subjects in comparison w

Externí odkaz: https://doaj.org/article/da5e4c1baa1d416c8844d0d5d9b8a290

Candidates for Repurposing as Anti-Virulence Agents Based on the Structural Profile Analysis of Microbial Collagenase Inhibitors

Autor: Georgiana Nitulescu, George Mihai Nitulescu, Anca Zanfirescu, Dragos Paul Mihai, Daniela Gradinaru

Publikováno v: Pharmaceutics, Vol 14, Iss 1, p 62 (2021)

The pharmacological inhibition of the bacterial collagenases (BC) enzymes is considered a promising strategy to block the virulence of the bacteria without targeting the selection mechanism leading to drug resistance. The chemical structures of the C

Externí odkaz: https://doaj.org/article/0080d70437da4bf3aaeec2d106d94ad1

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics

Autor: Laura Kananen, Mikko Hurme, Alexander Bürkle, Maria Moreno-Villanueva, Jürgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dollé, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Härkänen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimäki, Olli T. Raitakari, Olavi Ukkola, Mika Kähönen, Marja Jylhä, Juulia Jylhävä

Publikováno v: GEROSCIENCE
Kananen, L, Hurme, M, Bürkle, A, Moreno-Villanueva, M, Bernhardt, J, Debacq-Chainiaux, F, Grubeck-Loebenstein, B, Malavolta, M, Basso, A, Piacenza, F, Collino, S, Gonos, E S, Sikora, E, Gradinaru, D, Jansen, E H J M, Dollé, M E T, Salmon, M, Stuetz, W, Weber, D, Grune, T, Breusing, N, Simm, A, Capri, M, Franceschi, C, Slagboom, E, Talbot, D, Libert, C, Raitanen, J, Koskinen, S, Härkänen, T, Stenholm, S, Ala-Korpela, M, Lehtimäki, T, Raitakari, O T, Ukkola, O, Kähönen, M, Jylhä, M & Jylhävä, J 2022, ' Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics ', GeroScience, vol. 45, no. 1, pp. 85-103 . https://doi.org/10.1007/s11357-022-00590-8

Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes and metabolic processes that lead to elevated cf-DNA levels. We so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1937b684e94cf6fd814da6a2766df5
https://biblio.ugent.be/publication/01H3MEVG6Y0Y2FEYN73BRTMM0J/file/01H3MEYCVHDKPXJFS8FDX6YT26

Validation of protein carbonyl measurement: A multi-centre study

Autor: Edyta Augustyniak, Aisha Adam, Katarzyna Wojdyla, Adelina Rogowska-Wrzesinska, Rachel Willetts, Ayhan Korkmaz, Mustafa Atalay, Daniela Weber, Tilman Grune, Claudia Borsa, Daniela Gradinaru, Ravi Chand Bollineni, Maria Fedorova, Helen R. Griffiths

Publikováno v: Redox Biology, Vol 4, Iss C, Pp 149-157 (2015)

Protein carbonyls are widely analysed as a measure of protein oxidation. Several different methods exist for their determination. A previous study had described orders of magnitude variance that existed when protein carbonyls were analysed in a singl

Externí odkaz: https://doaj.org/article/eb668b4f188a4562a4b2b8d5b8eb4568

The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals

Autor: Gudrun von Scheven, Yves Artur, Claudia Borsa, Maria Moreno-Villanueva, Philippe Faure, Daniela Gradinaru, Lucie Oziol, Cristina Ionescu, Anca Ungurianu, Alexander Bürkle, Denisa Margina

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Hindawi, 2020, 2020, pp.3580934. ⟨10.1155/2020/3580934⟩
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)

International audience; Ionizing radiation induces genomic instability in living organisms, and several studies reported an ageing-dependent radiosensitivity. Chemical compounds, such as scavengers, radioprotectors, and modifiers, contribute to reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18c0d00b44c81a48060e5dd0622cd67
https://doi.org/10.1155/2020/3580934