Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniela G. Dengler"'
Autor:
Robert Ardecky, Daniela G. Dengler, Kaleeckal G. Harikumar, Mathew M. Abelman, Jiwen Zou, Bryan A. Kramer, Santhi Reddy Ganji, Steve Olson, Alina Ly, Nikhil Puvvula, Chen-Ting Ma, Raghuveer Ramachandra, Eduard A. Sergienko, Laurence J. Miller
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100176- (2024)
Agonists of the secretin receptor have potential applications for diseases of the cardiovascular, gastrointestinal, and metabolic systems, yet no clinically-active non-peptidyl agonists of this receptor have yet been developed. In the current work, w
Externí odkaz:
https://doaj.org/article/3eddfc13db42404aa4f87b29244f0ab2
Autor:
Daniela G. Dengler, Qing Sun, Kaleeckal G. Harikumar, Laurence J. Miller, Eduard A. Sergienko
Publikováno v:
SLAS Discovery, Vol 27, Iss 7, Pp 384-394 (2022)
Obesity has become a prevailing health burden globally and particularly in the US. It is associated with many health problems, including cardiovascular disease, diabetes and poorer mental health. Hence, there is a high demand to find safe and effecti
Externí odkaz:
https://doaj.org/article/422a6a6075cb48808eb30e6c246e9ece
Autor:
Daniela G. Dengler, Kaleeckal G. Harikumar, Alice Yen, Eduard A. Sergienko, Laurence J. Miller
Publikováno v:
Membranes, Vol 13, Iss 2, p 150 (2023)
As part of an ongoing effort to develop a drug targeting the type 1 cholecystokinin receptor (CCK1R) to help prevent and/or treat obesity, we recently performed a high throughput screening effort of small molecules seeking candidates that enhanced th
Externí odkaz:
https://doaj.org/article/12fce92a66594ac0a74ef2c42448a870
Autor:
Kaleeckal G. Harikumar, Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness, Arthur Christopoulos, Denise Wootten, Eduard A. Sergienko, Patrick M. Sexton, Laurence J. Miller
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Drugs useful in prevention/treatment of obesity could improve health. Cholecystokinin (CCK) is a key regulator of appetite, working through the type 1 CCK receptor (CCK1R); however, full agonists have not stimulated more weight loss than dieting. We
Externí odkaz:
https://doaj.org/article/895703c860ab400c964a97eea810e55b
Autor:
Dylan Finneran, Qingyou Li, Meena S. Subbarayan, Aurelie Joly‐Amado, Siddharth Kamath, Daniela G. Dengler, Marcia N. Gordon, Michael R. Jackson, Dave Morgan, Paula C. Bickford, Layton H. Smith, Kevin R. Nash
Publikováno v:
GliaREFERENCES. 71(2)
Fractalkine (FKN) is a membrane-bound chemokine that can be cleaved by proteases such as ADAM 10, ADAM 17, and cathepsin S to generate soluble fragments. Studies using different forms of the soluble FKN yield conflicting results in vivo. These observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a625c1f405b3c2651058e648b96a88
https://pubmed.ncbi.nlm.nih.gov/36106533
https://pubmed.ncbi.nlm.nih.gov/36106533
Autor:
Laurence Miller, Daniela G. Dengler, Eduard Sergienko, Robert Ardecky, Sirkku Pollari, Kaleeckal G. Harikumar, Qing Sun
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4372466f733c2f22375af2b2d9b0da98
https://doi.org/10.1096/fasebj.2021.35.s1.03368
https://doi.org/10.1096/fasebj.2021.35.s1.03368
Autor:
Qing Sun, John Holleran, Brock T. Brown, Robert Ardecky, Eduard Sergienko, Daniela G. Dengler, Jannis Beutel, Aki Shinoki Iwaya, Sirkku Pollari, Kaleeckal G. Harikumar, Laurence J. Miller
Publikováno v:
SLAS Discov
The secretin receptor (SCTR), a prototypical class B G protein-coupled receptor (GPCR), exerts its effects mainly by activating Gαs proteins upon binding of its endogenous peptide ligand secretin. SCTRs can be found in a variety of tissues and organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2920372fdd0692a67a55f3fa45bbca24
https://europepmc.org/articles/PMC8278649/
https://europepmc.org/articles/PMC8278649/
Autor:
John Holleran, Harikumar G. Kaleeckal, Daniela G. Dengler, Eduard Sergienko, Jannis Beutel, Chen-Ting Ma, Sirkku Pollari, Laurence J. Miller, Qing Sun
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf9cb7cc6414bb26ec26ea1062061d31
https://doi.org/10.1096/fasebj.2020.34.s1.07363
https://doi.org/10.1096/fasebj.2020.34.s1.07363