Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniela Diehl"'
Autor:
Doris Oesterle, Martin W. Elmlinger, Esther Hessel, Andreas Hoeflich, Martina Langhammer, Ingrid Renner-Müller, Harald Lahm, Daniela Diehl, Eckhard Wolf, Martin Göttlicher
Publikováno v:
International Journal of Cancer. 124:2220-2225
Colon cancer patients frequently show increased levels of serum insulin-like growth factor-binding protein-2 (IGFBP-2), however, the pathogenetic relevance of this phenomenon for colorectal cancer is unclear. Therefore, we have used IGFBP-2 transgeni
Autor:
Karin Hoffmann, Vera Mick, Stefan Knackmuss, Melvyn Little, Georg J. Arnold, Daphne Nikles, Harald Lahm, Eckhard Wolf, Thomas Fröhlich, Bertram Brenig, Ekaterina Vlasova, Georgeta Zemora, Daniela Diehl, Chantal Zuber, Uwe Reusch, Stefan Weiss
Publikováno v:
Journal of Molecular Biology. 378:530-539
The 37-kDa/67-kDa laminin receptor precursor/laminin receptor (LRP/LR) acting as a receptor for prions and viruses is overexpressed in various cancer cell lines, and their metastatic potential correlates with LRP/LR levels. We analyzed the tumorigeni
Publikováno v:
Carcinogenesis. 28:1446-1454
Colorectal cancer is the second leading cause of cancer deaths worldwide with diet playing a prominent role in disease initiation and progression. Flavonoids are secondary plant compounds that are suggested as protective ingredients of a diet rich in
Publikováno v:
Journal of Cellular Physiology. 178:341-348
Di- and tripeptides and peptide mimetics such as β-lactam antibiotics are efficiently reabsorbed from the tubular lumen by a high-affinity peptide transporter. We have recently identified and characterized this H+-coupled high-affinity peptide trans
Publikováno v:
American Journal of Physiology-Cell Physiology. 275:C1573-C1579
The reabsorption of filtered di- and tripeptides as well as certain peptide mimetics from the tubular lumen into renal epithelial cells is mediated by an H+-coupled high-affinity transport process. Here we demonstrate for the first time H+-coupled up
Autor:
Martin Bentz, K. Fischer, Johannes F. Coy, Peter R. Galle, Werner Hunstein, Richard F. Schlenk, Georges Cabot, Hartmut Döhner, Martin Volkmann, Annemarie Poustka, Peter Lichter, Stephan Stilgenbauer, Axel Benner, Daniela Diehl, Katrin Hansen
Publikováno v:
Blood. 85:1580-1589
Conventional cytogenetic analysis in B-cell chronic lymphocytic leukemia (B-CLL) has been very difficult, and the prognostic significance of specific chromosome aberrations is under discussion. Recent improvements in fluorescence in situ hybridizatio
Autor:
I. Renner-Müller, Daniela Diehl, E. Braunreuther, Eckhard Wolf, M. Göttlicher, Andreas Hoeflich, D. Oesterle
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 113
Elevated expression of IGFBP-2 is often found under malignant conditions in vivo. However, to date it is unknown if high levels of IGFBP-2 exert positive or negative effects during development or progression of tumors. In vitro, conditional effects o
Publikováno v:
International journal of cancer. 113(4)
Insulin-like growth factor II (IGF-II) is expressed commonly in colorectal tumors. IGF-binding protein-4 (IGFBP-4) counteracts the tumor promoting activities of IGF-II by binding this growth factor. We have shown previously that in LS1034 cells, whic
Publikováno v:
Cancer research. 64(5)
Effects of insulin-like growth factor-binding protein-4 (IGFBP-4) on proliferation, colony formation, and cell migration were assessed in IGF-sensitive and -insensitive colorectal cancer cell lines. In IGF-insensitive Isreco-1 cells, overexpression o
Publikováno v:
The Journal of endocrinology. 178(2)
IGFs have multiple functions regarding cellular growth, survival and differentiation under different physiological and pathological conditions. IGF effects are modulated systemically and locally by six high-affinity IGF-binding proteins (IGFBP-1 to -