Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Daniela Corda"'
Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells
Autor:
Angela Filograna, Stefano De Tito, Matteo Lo Monte, Rosario Oliva, Francesca Bruzzese, Maria Serena Roca, Antonella Zannetti, Adelaide Greco, Daniela Spano, Inmaculada Ayala, Assunta Liberti, Luigi Petraccone, Nina Dathan, Giuliana Catara, Laura Schembri, Antonino Colanzi, Alfredo Budillon, Andrea Rosario Beccari, Pompea Del Vecchio, Alberto Luini, Daniela Corda, Carmen Valente
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-32 (2024)
Abstract Background The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission inducing protein required for membrane trafficking and Golgi complex part
Externí odkaz:
https://doaj.org/article/1518a1c715734851bf4b6f4560bdaa4e
Autor:
Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti, Daniela Corda
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia formation and activity is
Externí odkaz:
https://doaj.org/article/8bfd1be0963b48b49765307895c9d275
Autor:
Gioia Boncompagni, Alessia Varone, Vanessa Tatangelo, Nagaja Capitani, Federica Frezzato, Andrea Visentin, Livio Trentin, Daniela Corda, Cosima T. Baldari, Laura Patrussi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
An imbalance in the expression of pro- and anti-apoptotic members of the Bcl-2 family of apoptosis-regulating proteins is one of the main biological features of CLL, highlighting these proteins as therapeutic targets for treatment of this malignancy.
Externí odkaz:
https://doaj.org/article/ecef887653664fcd9795e727d12332b6
Autor:
Simone Di Paola, Maria Matarese, Maria Luisa Barretta, Nina Dathan, Antonino Colanzi, Daniela Corda, Giovanna Grimaldi
Publikováno v:
Cancers, Vol 14, Iss 21, p 5210 (2022)
Intracellular mono-ADP-ribosyltransferases (mono-ARTs) catalyze the covalent attachment of a single ADP-ribose molecule to protein substrates, thus regulating their functions. PARP10 is a soluble mono-ART involved in the modulation of intracellular s
Externí odkaz:
https://doaj.org/article/09a64ec701d347c8b24f6820e5a25d66
Autor:
Alessia Varone, Stefania Mariggiò, Manpreet Patheja, Vincenzo Maione, Antonio Varriale, Mariangela Vessichelli, Daniela Spano, Fabio Formiggini, Matteo Lo Monte, Nadia Brancati, Maria Frucci, Pompea Del Vecchio, Sabato D’Auria, Angela Flagiello, Clara Iannuzzi, Alberto Luini, Piero Pucci, Lucia Banci, Carmen Valente, Daniela Corda
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-21 (2019)
Abstract Background Shp1, a tyrosine-phosphatase-1 containing the Src-homology 2 (SH2) domain, is involved in inflammatory and immune reactions, where it regulates diverse signalling pathways, usually by limiting cell responses through dephosphorylat
Externí odkaz:
https://doaj.org/article/56f9ef9873944b5b84f148cb4d4fd815
Autor:
Laura Gastaldi, Josefina Inés Martín, Lucas Javier Sosa, Gonzalo Quassollo, Yael Macarena Peralta Cuasolo, Carmen Valente, Alberto Luini, Daniela Corda, Alfredo Cáceres, Mariano Bisbal
Publikováno v:
Cells, Vol 11, Iss 8, p 1320 (2022)
Neurons are highly polarized cells requiring precise regulation of trafficking and targeting of membrane proteins to generate and maintain different and specialized compartments, such as axons and dendrites. Disruption of the Golgi apparatus (GA) sec
Externí odkaz:
https://doaj.org/article/74404149447d4acfb5ecb4bca6ad79cb
Autor:
Ana Margarida Campos, Genoveffa Nuzzo, Alessia Varone, Paola Italiani, Diana Boraschi, Daniela Corda, Angelo Fontana
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Glycerophosphoinositols (GPIs) are water-soluble bioactive phospholipid derivatives of increasing interest as intracellular and paracrine mediators of eukaryotic cell functions. The most representative compound of the family is glycerophosphoinositol
Externí odkaz:
https://doaj.org/article/8e07e088b6f74cd8b2fa347cabe5d622
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Shp1 is a cytosolic tyrosine phosphatase that regulates a broad range of cellular functions and targets, modulating the flow of information from the cell membrane to the nucleus. While initially studied in the hematopoietic system, research conducted
Externí odkaz:
https://doaj.org/article/a91024701c0c4e12b3e221418ceea492
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
One of the fundamental features of biomembranes is the ability to fuse or to separate. These processes called respectively membrane fusion and fission are central in the homeostasis of events such as those related to intracellular membrane traffic. P
Externí odkaz:
https://doaj.org/article/187e9c124a05438dbd29aa1d0df50a9f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Lipid-modifying enzymes serve crucial roles in cellular processes such as signal transduction (producing lipid-derived second messengers), intracellular membrane transport (facilitating membrane remodeling needed for membrane fusion/fission), and pro
Externí odkaz:
https://doaj.org/article/51a93cd40da049798500ce15971e273a