Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Daniela Calini"'
TARDBP mutations in a cohort of Italian patients with Parkinson’s disease and atypical parkinsonisms
Autor:
Cinzia Tiloca, Stefano Goldwurm, Narghes Calcagno, Federico Verde, Silvia Peverelli, Daniela Calini, Anna Lena Zecchinelli, Davide Sangalli, Antonia Ratti, Gianni Pezzoli, Vincenzo Silani, Nicola Ticozzi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundAggregates of TAR DNA-binding protein of 43 kDa (TDP-43) represent the pathological hallmark of most amyotrophic lateral sclerosis (ALS) and of nearly 50% of frontotemporal dementia (FTD) cases but were also observed to occur as secondary n
Externí odkaz:
https://doaj.org/article/eb671e391cbd40588ece756b7b9d30d2
Autor:
Helena L. Crowell, Charlotte Soneson, Pierre-Luc Germain, Daniela Calini, Ludovic Collin, Catarina Raposo, Dheeraj Malhotra, Mark D. Robinson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Single-cell transcriptomics enhanced our ability to profile heterogeneous cell populations. It is not known which statistical frameworks are performant to detect subpopulation-level responses. Here, the authors developed a simulation framework to eva
Externí odkaz:
https://doaj.org/article/ca630df4491c4fa29d160b6e84f04cc4
Autor:
Anna Nolle, Irene van Dijken, Ciril M. Waelti, Daniela Calini, Julien Bryois, Emmanuelle Lezan, Sabrina Golling, Angelique Augustin, Lynette Foo, Jeroen J. M. Hoozemans
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Glia cells have a crucial role in the central nervous system and are involved in the majority of neurological diseases. While glia isolation techniques are well established for rodent brain, only recent advances in isolating glial cells from human br
Externí odkaz:
https://doaj.org/article/00bb2f85087b4fa1917f4bc8d6ddec13
Autor:
Julien Bryois, Daniela Calini, Will Macnair, Lynette Foo, Eduard Urich, Ward Ortmann, Victor Alejandro Iglesias, Suresh Selvaraj, Erik Nutma, Manuel Marzin, Sandra Amor, Anna Williams, Gonçalo Castelo-Branco, Vilas Menon, Philip De Jager, Dheeraj Malhotra
Publikováno v:
Nature Neuroscience, 25(8), 1104-1112. Nature Publishing Group
Bryois, J, Calini, D, Macnair, W, Foo, L, Urich, E, Ortmann, W, Iglesias, V A, Selvaraj, S, Nutma, E, Marzin, M, Amor, S, Williams, A, Castelo-Branco, G, Menon, V, De Jager, P & Malhotra, D 2022, ' Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders ', Nature Neuroscience, vol. 25, no. 8, pp. 1104-1112 . https://doi.org/10.1038/s41593-022-01128-z
Bryois, J, Calini, D, Macnair, W, Foo, L, Urich, E, Ortmann, W, Iglesias, V A, Selvaraj, S, Nutma, E, Marzin, M, Amor, S, Williams, A, Castelo-Branco, G, Menon, V, De Jager, P & Malhotra, D 2022, ' Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders ', Nature Neuroscience, vol. 25, no. 8, pp. 1104-1112 . https://doi.org/10.1038/s41593-022-01128-z
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types. In this study, we performed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2001352763494c39c5cca9ed221bcc4a
http://www.scopus.com/inward/record.url?scp=85135229265&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85135229265&partnerID=8YFLogxK
Autor:
Will Macnair, Daniela Calini, Eneritz Agirre, Julien Bryois, Sarah Jäkel, Petra Kukanja, Nadine Stokar-Regenscheit, Virginie Ott, Lynette C. Foo, Ludovic Collin, Sven Schippling, Eduard Urich, Erik Nutma, Manuel Marzin, Sandra Amor, Roberta Magliozzi, Elyas Heidari, Mark D. Robinson, Charles ffrench-Constant, Gonçalo Castelo-Branco, Anna Williams, Dheeraj Malhotra
The lack of understanding as to the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies and biomarkers. Here, to address this gap, we analysed 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82ac11ba9c2fd8f4a2ebc946257f7694
https://doi.org/10.1101/2022.04.06.487263
https://doi.org/10.1101/2022.04.06.487263
Autor:
Mandy Meijer, Eneritz Agirre, Mukund Kabbe, Cassandra A. van Tuijn, Abeer Heskol, Chao Zheng, Ana Mendanha Falcão, Marek Bartosovic, Leslie Kirby, Daniela Calini, Michael R. Johnson, M. Ryan Corces, Thomas J. Montine, Xingqi Chen, Howard Y. Chang, Dheeraj Malhotra, Gonçalo Castelo-Branco
Publikováno v:
1210.e13
Multiple sclerosis (MS) is characterized by a targeted attack on oligodendroglia (OLG) and myelin by immune cells, which are thought to be the main drivers of MS susceptibility. We found that immune genes exhibit a primed chromatin state in single mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ce9ac6f1464f87dc6faf799e0b7772
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-474007
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-474007
Autor:
E. Urich, Dheeraj Malhotra, Daniela Calini, Anna Williams, L. Foo, Sandra Amor, Julien Bryois, Manuel C. Marzin, Gonçalo Castelo-Branco, S. Selvaraj, V. A. Iglesias, W. Ortmann, W. Macnair, P. L. De Jager, Vilas Menon, Erik Nutma
Most expression quantitative trait loci (eQTL) studies to date have been performed in heterogeneous brain tissues as opposed to specific cell types. To investigate the genetics of gene expression in adult human cell types from the central nervous sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0cf5222e77753624d771abfae8e73b
https://doi.org/10.1101/2021.10.09.21264604
https://doi.org/10.1101/2021.10.09.21264604
Autor:
Julien Bryois, Tobias Derfuss, Hanane Touil, Vilas Menon, Ilaria Callegiri, Dheeraj Malhotra, Daniela Calini, Samantha Epstein, Catarina Raposo, Claire S Riley, Tina Roostaei, Licinio Craveiro, Philip L. De Jager, Claudiu Diaconu
ImportanceA robust cerebrospinal fluid (CSF) cell cryopreservation protocol using high resolution single-cell (sc) transcriptomic data would enable the deployment of this important modality in multi-center translational research studies and clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1513da6ece9b1770c6341a855c67750f
https://doi.org/10.1101/2021.09.15.460354
https://doi.org/10.1101/2021.09.15.460354
Autor:
Almut Lütge, Mark D. Robinson, Daniela Calini, Joanna Zyprych-Walczak, Helena L. Crowell, Charlotte Soneson, Urszula Brykczynska Kunzmann, Dheeraj Malhotra
Publikováno v:
Life Science Alliance
A systematic comparison of batch effect metrics for single cell data is performed. The new cell-specific mixing score from the R/Bioconductor CellMixS package performs well across various tasks.
A key challenge in single-cell RNA-sequencing (scR
A key challenge in single-cell RNA-sequencing (scR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a854055bef6d19ab5287930776c83cc8
https://www.zora.uzh.ch/id/eprint/206053/
https://www.zora.uzh.ch/id/eprint/206053/
Autor:
U. Brykczynska Kunzmann, Mark D. Robinson, J. Zyprych-Walczak, Dheeraj Malhotra, Helena L. Crowell, Charlotte Soneson, Daniela Calini, A. Luetge
A key challenge in single cell RNA-sequencing (scRNA-seq) data analysis are dataset- and batch-specific differences that can obscure the biological signal of interest. While there are various tools and methods to perform data integration and correct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2719d041d5d4507e3e06439e4d2ceaf3
https://doi.org/10.1101/2020.12.11.420885
https://doi.org/10.1101/2020.12.11.420885