Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniela C Oniciu"'
Autor:
Marine Goffinet, Claudine Tardy, Nadia Boubekeur, Guy Cholez, Alice Bluteau, Daniela C Oniciu, Narendra D Lalwani, Jean-Louis H Dasseux, Ronald Barbaras, Rudi Baron
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95807 (2014)
High-density lipoprotein (HDL) is known to protect against atherosclerosis by promoting the reverse cholesterol transport. A new pathway for the regulation of HDL-cholesterol (HDL-c) removal involving F1-ATPase and P2Y13 receptor (P2Y13R) was describ
Externí odkaz:
https://doaj.org/article/92b5031bc3194d3a9c2d0950d680be5d
Publikováno v:
ARKIVOC, Vol 2005, Iss 10, Pp 285-291 (2005)
Externí odkaz:
https://doaj.org/article/9a22fa08886941db9940b503a158d3e4
Autor:
Clay T. Cramer, Brian Goetz, Krista L.M. Hopson, Gregory J. Fici, Rose M. Ackermann, Stephen C. Brown, Charles L. Bisgaier, W.G. Rajeswaran, Daniela C. Oniciu, Michael E. Pape
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1289-1301 (2004)
We have identified a novel ω-hydroxy-alkanedicarboxylic acid, ESP 55016, that favorably alters serum lipid variables in obese female Zucker (fa/fa) rats. ESP 55016 reduced serum non-HDL-cholesterol (non-HDL-C), triglyceride, and nonesterified fatty
Externí odkaz:
https://doaj.org/article/6e66dc604caa440cad0b2da77bb5ad67
Autor:
Roel P L, Bell, Dennis, Verdijk, Mike, Relou, Dennis, Smith, Henk, Regeling, Eelco J, Ebbers, Frank M C, Leemhuis, Daniela C, Oniciu, Clay T, Cramer, Brian, Goetz, Michael E, Pape, Brian R, Krause, Charles L, Bisgaier, Jean-Louis, Dasseux
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:223-236
A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on
Publikováno v:
Organic Preparations and Procedures International. 36:587-596
Autor:
Daniela C. Oniciu, Sergey Denisenko, Ralf Mueller, Charles L Bisgaier, Krista L Hopson, Bruce H McCosar, Tian-Bao Huang, Lian Hao Zhang, Brian Goetz, Caiming Duan, Jing Yang, Clay T Cramer, Catherine Delaney Freiman, Jean-Louis H Dasseux, Otto J Geoffroy, Michael E Pape, Emil Pop
Publikováno v:
Journal of Medicinal Chemistry. 47:6082-6099
Keto-substituted hydrocarbons with 11-19 methylene and bis-terminal hydroxyl and carboxyl groups have been synthesized and evaluated in both in vivo and in vitro assays for their potential to favorably alter lipid disorders including metabolic syndro
Autor:
Anna Denisenko, Ralf Mueller, Catherine Delaney Freiman, Emil Pop, Krista L Hopson, Charles L Bisgaier, Tian-Bao Huang, Daniela C. Oniciu, Lian Hao Zhang, Brian Goetz, Jing Yang, Olga V Denisko, Jean-Louis H Dasseux, Michael E Pape, Caiming Duan, Clay T Cramer
Publikováno v:
Journal of Medicinal Chemistry. 47:5183-5197
Long hydrocarbon chain ethers with bis-terminal hydroxyl or carboxyl groups have been synthesized and evaluated for their potential to favorably alter lipid disorders including metabolic syndrome. Compounds were assessed for their effects on the de n
Autor:
Rose Ackermann, Gregory J. Fici, Brian Goetz, Krista L.M. Hopson, Michael E. Pape, Daniela C. Oniciu, Stephen C. Brown, Clay T. Cramer, W.G. Rajeswaran, Charles L. Bisgaier
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1289-1301 (2004)
We have identified a novel omega-hydroxy-alkanedicarboxylic acid, ESP 55016, that favorably alters serum lipid variables in obese female Zucker (fa/fa) rats. ESP 55016 reduced serum non-HDL-cholesterol (non-HDL-C), triglyceride, and nonesterified fat
Publikováno v:
Chemical Reviews. 104:2777-2812
Autor:
Ronald Barbaras, Rudi Baron, Marine Goffinet, Claudine Tardy, Nadia Boubekeur, Guy Cholez, Daniela C Oniciu, Narendra D Lalwani, Jean-Louis H Dasseux
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32
The F1-ATPase/P2Y13 receptor pathway has been involved in the regulation of the HDL uptake liver and disposition via the reverse cholesterol transport. CT1007900 is a novel selective P2Y13 receptor agonist that has been shown to enhance the HDL uptak