Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Daniela Buac"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 12, Pp 1379-1390 (2013)
Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer. Clinical trials using the United States Food and Drug Administ
Externí odkaz:
https://doaj.org/article/bc0eb3b72a15435ab13de00f3b5a35d6
Autor:
Nan Zhang, Daniela Buac, Xia Zhang, Zhen Zhang, Yuhua Fan, Yanfei Ma, Q. Ping Dou, Caifeng Bi, Gui-Mei Huang, Xin-ping Wang
Publikováno v:
Inorganica Chimica Acta. 466:478-485
Although cadmium is a widespread environmental contaminant and human carcinogen, our studies indicate an organic cadmium complex to be a potent inhibitor of proteasomal chymotrypsin-like (CT-like) activity, further capable of inducing apoptosis in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff49370e5b239a4bc23348092b88e3c
https://doi.org/10.1016/j.ica.2017.07.006
https://doi.org/10.1016/j.ica.2017.07.006
Publikováno v:
Expert Opinion on Therapeutic Targets. 17:1091-1108
The ubiquitin-proteasome system (UPS) degrades 80 - 90% of intracellular proteins. Cancer cells take advantage of the UPS for their increased growth and decreased apoptotic cell death. Thus, the components that make up the UPS represent a diverse gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e2a3fd12908d6888713a411c7dad9e
https://doi.org/10.1517/14728222.2013.815728
https://doi.org/10.1517/14728222.2013.815728
Autor:
Caifeng Bi, Xia Zhang, Daniela Buac, Q. Ping Dou, Pengfei Zhang, Lili Dong, Jian Zuo, Zhen Zhang, Nan Zhang, Yuhua Fan
Publikováno v:
Journal of Inorganic Biochemistry. 123:1-10
Although cadmium (Cd) is a widespread environmental contaminant and human carcinogen, our studies indicate an organic Cd complex to be a potent inhibitor of proteasomal chymotrypsin-like (CT-like) activity, further capable of inducing apoptosis in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0928abed9d0a4754e948cc716ddcc709
https://doi.org/10.1016/j.jinorgbio.2013.02.004
https://doi.org/10.1016/j.jinorgbio.2013.02.004
Autor:
Rahul Deshmukh, Daniela Buac, Bharati Mitra, Sara M. Schmitt, Christine Neslund-Dudas, Fathima R. Kona, Q. Ping Dou, Zhen Zhang, Min Shen
Publikováno v:
Current Pharmaceutical Design. 19:4025-4038
The cancer drug discovery field has placed much emphasis on the identification of novel and cancer-specific molecular targets. A rich source of such targets for the design of novel anti-tumor agents is the ubiqutin-proteasome system (UP-S), a tightly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51593a240a23318ca7a65ce922ce45d4
https://doi.org/10.2174/1381612811319220012
https://doi.org/10.2174/1381612811319220012
Publikováno v:
Breast Cancer Research and Treatment. 135:495-503
RNF115, or Breast Cancer-Associated Gene 2 (BCA2), encodes a RING-finger ubiquitin E3 ligase, expression of which was associated with estrogen receptor (ER)-positive status in human breast tumors. Although the BCA2 promoter contains several estrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94d2533c67fab85cdcb33979ebb7328
https://doi.org/10.1007/s10549-012-2107-4
https://doi.org/10.1007/s10549-012-2107-4
Autor:
Fathima R. Kona, Andrea Brancale, Andrew D. Westwell, Ghali Brahemi, Angelika M Burger, Jitka Soukupova, Daniela Buac, Annalisa Fiasella
Publikováno v:
Journal of Medicinal Chemistry. 53:2757-2765
The zinc-ejecting aldehyde dehydrogenase (ALDH) inhibitory drug disulfiram (DSF) was found to be a breast cancer-associated protein 2 (BCA2) inhibitor with potent antitumor activity. We herein describe our work in the synthesis and evaluation of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679796650337e2efe484223277b12e49
https://doi.org/10.1021/jm901757t
https://doi.org/10.1021/jm901757t
Autor:
P. Leif Bergsagel, Lawrence H. Boise, Louise M. Carlson, Marta Chesi, Megan Murray, Catherine M. Gavile, Adam Utley, Jayakumar R. Nair, Kelvin P. Lee, Daniela Buac, Chandana Koorella
Publikováno v:
Blood. 123(24)
Chemotherapeutic resistance remains a significant hurdle in the treatment of multiple myeloma (MM) and is significantly mediated by interactions between MM cells and stromal cells of the bone marrow microenvironment. Despite the importance of these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611225955e51a8fdbb6413df5eeb5837
https://pubmed.ncbi.nlm.nih.gov/24782505
https://pubmed.ncbi.nlm.nih.gov/24782505
Publikováno v:
Clinical and Experimental Pharmacology.
Copyright: © 2013 Buac D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1672cfd7062966e96134b8de2920f2
https://doi.org/10.4172/2161-1459.1000116
https://doi.org/10.4172/2161-1459.1000116
Proliferation and apoptosis pathways are tightly regulated in a cell by the ubiquitin-proteasome system (UPS) and alterations in the UPS may result in cellular transformation or other pathological conditions. Indeed, the proteasome is often found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba462cc8de00a378e4f25ff35ab08f8
http://hdl.handle.net/11577/2837122
http://hdl.handle.net/11577/2837122
