The Substrate Radical of Escherichia coli Oxygen-independent Coproporphyrinogen III Oxidase HemN

Autor: Gunhild Layer, Lothar Jänsch, Daniela Breckau, Stephen E. J. Rigby, Helen K. Leech, Dirk W. Heinz, Martin J. Warren, Dieter Jahn, Antonio J. Pierik, I. Astner, Katrin Grage, Matthias Trost, Peter Heathcote

Publikováno v: Journal of Biological Chemistry. 281:15727-15734

During porphyrin biosynthesis the oxygen-independent coproporphyrinogen III oxidase (HemN) catalyzes the oxidative decarboxylation of the propionate side chains of rings A and B of coproporphyrinogen III to form protoporphyrinogen IX. The enzyme util

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119319f73654168a694636b0b48be0b2
https://doi.org/10.1074/jbc.m512628200

Heme biosynthesis is coupled to electron transport chains for energy generation

Autor: Martina Jahn, Jürgen Moser, Rebekka Biedendieck, Susanne Schröder, Daniela Breckau, Rodrigo Arias-Cartin, Kalle Möbius, Dörte Becher, Anna-Lena Hännig, Axel Magalon, Katrin Riedmann, Dieter Jahn

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (23), pp.10436-10441. ⟨10.1073/pnas.1000956107⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (23), pp.10436-10441. ⟨10.1073/pnas.1000956107⟩

Cellular energy generation uses membrane-localized electron transfer chains for ATP synthesis. Formed ATP in turn is consumed for the biosynthesis of cellular building blocks. In contrast, heme cofactor biosynthesis was found driving ATP generation v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423e3f4c3693c3e3bfb4ae4abdc1d972
https://hal.science/hal-03248745

Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese

Autor: Daniela Breckau, Gunhild Layer, Anselm Sauerwald, Esther Mahlitz, Dieter Jahn

Publikováno v: The Journal of biological chemistry. 278(47)

During heme biosynthesis in Escherichia coli two structurally unrelated enzymes, one oxygen-dependent (HemF) and one oxygen-independent (HemN), are able to catalyze the oxidative decarboxylation of coproporphyrinogen III to form protoporphyrinogen IX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5bec9c1420285d0b51cc43699c00c0
https://pubmed.ncbi.nlm.nih.gov/12975365