Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Daniela Borghi"'
Autor:
Alessandra Cirla, Elena Casale, Nilla Avanzi, Marina Ciomei, Viviana Desperati, Helena Posteri, Eduard R. Felder, Gianluca Papeo, Alessia Montagnoli, Arturo Galvani, Marco Guanci, Daniela Borghi, Antonella Isacchi, Daniele Donati, Sonia Rainoldi, Alessandra Scolaro, Paolo Orsini, Federico Riccardi-Sirtori
Publikováno v:
ACS Medicinal Chemistry Letters. 10:534-538
[Image: see text] Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD(+) to modify substrate proteins via the attachment of poly(ADP-ribose) chains. PARP-1 is a well est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbcfb19d60bc21f88fbc01fa3fe8976
https://doi.org/10.1021/acsmedchemlett.8b00569
https://doi.org/10.1021/acsmedchemlett.8b00569
Autor:
Christian Orrenius, Antonio Lomolino, Claudia Perrera, Paola Gnocchi, Nilla Avanzi, Elena Casale, Francesca Quartieri, Marcella Nesi, Arturo Galvani, Marina Fasolini, Emiliana Corti, Daniele Donati, Federico Riccardi-Sirtori, Maria Laura Giorgini, Stefania Re Depaolini, Enea Salsi, Eduard R. Felder, Antonella Isacchi, Daniela Borghi, Ulisse Cucchi, Maria Menichincheri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 51:128310
In this article we describe the identification of unprecedented ATP-competitive ChoKα inhibitors starting from initial hit NMS-P830 that binds to ChoKα in an ATP concentration-dependent manner. This result is confirmed by the co-crystal structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28088bfd6a53b4154d2a1addbdf62e8
https://doi.org/10.1016/j.bmcl.2021.128310
https://doi.org/10.1016/j.bmcl.2021.128310
Autor:
Arturo Galvani, Daniele Donati, Emiliana Corti, Alessandra Cirla, Paolo Orsini, Elena Casale, Francesco Sola, Mikhail Krasavin, Marina Fasolini, Enrico Pesenti, Barbara Forte, Rita Perego, Antonella Isacchi, Alina Busel, Daniela Borghi, Alessia Montagnoli, Fabio Zuccotto, Federico Riccardi-Sirtori, Eduard R. Felder, Helena Posteri, Rosita Lupi, Alexander Viktorovich Khvat, Marina Ciomei, Daniele Pezzetta, Gianluca Papeo, Matteo D'anello, Sonia Rainoldi, Francesco Caprera, Alessandra Scolaro
Publikováno v:
Journal of Medicinal Chemistry. 58:6875-6898
The nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) has a well-established role in the signaling and repair of DNA and is a prominent target in oncology, as testified by the number of candidates in clinical testing that unselectively target bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155b01fe1feb286b71832148160cb556
https://doi.org/10.1021/acs.jmedchem.5b00680
https://doi.org/10.1021/acs.jmedchem.5b00680
Autor:
Gianluca Papeo, Viviana Desperati, Daniela Borghi, Laura Elisabetta Mesiano, Francesca Quartieri, Cesare Gennari
Publikováno v:
European Journal of Organic Chemistry. 2011:6794-6801
The aromatic bisabolene sesquiterpene of marine origin (+)-7,11-helianane (1) and its moderately cytotoxic halogenated relative (+)-5-chloro-7,11-helianane (3) have been synthesized by a concise, stereoselective route. By capitalizing on a palladium-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c68ca42364be1a1d5cf76e0150e34d3
https://doi.org/10.1002/ejoc.201100706
https://doi.org/10.1002/ejoc.201100706
Autor:
Nilla Avanzi, Wilma Pastori, Marina Ciomei, Valter Croci, James R. Bischoff, Elena Casale, Francesco Fiorentini, Maria Gabriella Brasca, Ciro Mercurio, Paolo Pevarello, Clara Albanese, Rachele Alzani, Antonella Isacchi, Anna Vulpetti, Mario Varasi, Paolo Orsini, Daniela Borghi, Enrico Pesenti, Patrick Roussel, Dario Ballinari, Raffaella Amici, Marcella Nesi, Daniele Volpi
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:1844-1853
We have recently reported CDK inhibitors based on the 6-substituted pyrrolo[3,4-c]pyrazole core structure. Improvement of inhibitory potency against multiple CDKs, antiproliferative activity against cancer cell lines and optimization of the physico-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e3228318332fc37ba03b9ea13c1ff4
https://doi.org/10.1016/j.bmc.2010.01.042
https://doi.org/10.1016/j.bmc.2010.01.042
Autor:
Beatrice Malgesini, Daniela Borghi, Gianluca Papeo, Francesca Quartieri, Cesare Gennari, Barbara Forte
Publikováno v:
Chemistry - A European Journal. 15:7922-7929
A total synthesis of the tripeptide alkaloid (-)-chaetominine (1) was achieved in 9.3% overall yield starting from commercially available D-tryptophan methyl ester, based on a short and straightforward (nine steps) sequence. The early stage introduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe207b94a51e669afcbca400b38419fe
https://doi.org/10.1002/chem.200900793
https://doi.org/10.1002/chem.200900793
Autor:
Daniela Borghi, Francesca Quartieri, Gianluca Papeo, Nicola Mongelli, Helena Posteri, Federico Tutino
Publikováno v:
Tetrahedron. 65:2372-2376
(Z)-Axinohydantoin and (Z)-debromoaxinohydantoin, two pyrrole–imidazole alkaloids isolated from different marine sponges, possess moderate activities in inhibiting the progress of the cell cycle at different phases. A stereoselective synthesis of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3603b4c6b899ff4ae83fa4ec01327c5c
https://doi.org/10.1016/j.tet.2008.12.053
https://doi.org/10.1016/j.tet.2008.12.053
Autor:
Nilla Avanzi, Fabio Gasparri, Roberto D'Alessio, Barbara Salom, Graziella Sorrentino, Liviana Cozzi, Antonio Lomolino, Daniele Donati, Michele Caruso, Arturo Galvani, Steven Magnuson, Thomas O'Brien, Alessandra Cirla, Daniela Borghi, Antonella Isacchi, Daniela Asa, Ilaria Motto, Alessandra Badari, Barbara Valsasina, Simona Rizzi, Paola Magnaghi, Maurizio Pasi, Giovanni Cervi, Beatrice Malgesini, Eduard R. Felder, Sonia Troiani
Publikováno v:
Journal of medicinal chemistry. 57(24)
Valosine-containing protein (VCP), also known as p97 or cdc48 in yeast, is a highly abundant protein belonging to the AAA ATPase family involved in a number of essential cellular functions, including ubiquitin–proteasome mediated protein degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4ae0b61d58a9c41877bdaaf3b71942
https://pubmed.ncbi.nlm.nih.gov/25474526
https://pubmed.ncbi.nlm.nih.gov/25474526
Publikováno v:
Tetrahedron Letters. 46:8635-8638
The first total synthesis of (±)-cyclooroidin, a member of the pyrrole–imidazole alkaloid family recently isolated from the sponge Agelas oroides in optically pure form, is described. The synthesis was achieved in nine linear steps, with an overal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa901df532d88955df3719e063d1b23
https://doi.org/10.1016/j.tetlet.2005.10.060
https://doi.org/10.1016/j.tetlet.2005.10.060
Autor:
Robert A. McArthur, Tiziano Bandiera, Enzo Brambilla, Daniela Borghi, Mario Varasi, E. Arlandini, Carla Caccia, Maria Antonietta Cervini, Paolo Cremonesi, Sergio Mantegani, Gabriella Traquandi
Publikováno v:
European Journal of Medicinal Chemistry. 34:107-124
A series of (3,5-dioxopiperazin-1-yl)ergoline derivatives has been synthesised and evaluated in vitro and in vivo for their dopaminergic D1 and D2 components. The structural contributions to the pharmacological profile of the ergoline skeleton, its s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2ea886920f4270d1deeec2843a7f04
https://doi.org/10.1016/s0223-5234(99)80045-2
https://doi.org/10.1016/s0223-5234(99)80045-2