Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Daniela Baldoni"'
Autor:
Pierre-Eric Juif, Daniela Baldoni, Maribel Reyes, Darren Wilbraham, Salvatore Febbraro, Andrea Vaclavkova, Matthias Hoch, Jasper Dingemanse
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2636 (2017)
The pharmacokinetics, pharmacodynamics, tolerability, and food effect of cenerimod, a potent sphingosine-1-phosphate subtype 1 receptor modulator, were investigated in three sub-studies. Two double-blind, placebo-controlled, randomised studies in hea
Externí odkaz:
https://doaj.org/article/260b05216d05446e8cd2f03ca13e8e4f
Autor:
Kerry Anne Rogers, Pearlly Yan, Ian W. Flinn, Deborah M. Stephens, Thomas J. Kipps, Sarah M. Larson, Laura Martz, Xi Chen, Huabao Wang, Ethan Hopping, Ralf Bundschuh, Alexandra Acosta, Daniela Baldoni, Anwesha Chaudhury, Jeanne Whalen, Nadia B. Hassounah, Nina Orwitz, Janghee Woo, John C. Byrd
Publikováno v:
Cancer Research, vol 83, iss 8_Supplement
Introduction VAY736 is an afucosylated, human monoclonal antibody engineered to enhance antibody-dependent cellular cytotoxicity that targets BAFF-R+ B cells for elimination. In preclinical CLL models, VAY736 showed antileukemic activity and, when co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b058004b09c48b907cbfd85a4f211f3
https://escholarship.org/uc/item/7hp9q9d7
https://escholarship.org/uc/item/7hp9q9d7
Autor:
David, Pearson, Yi, Jin, Andrea, Romeo, Bertrand-Luc, Birlinger, Hilmar, Schiller, Yan, Ji, Mithat, Gunduz, Daniela, Baldoni, Markus, Walles
Publikováno v:
Xenobiotica. 52:26-37
LSZ102 is an orally bioavailable selective oestrogen receptor degrader in clinical development for the treatment of breast cancer. Preclinical studies showed efficacy in xenograft models on oral dosing. However, oral bioavailability was relatively lo
Autor:
Emma M. Groarke, Danielle M. Townsley, Fernanda Gutierrez-Rodrigues, Olga Rios, Bhavisha A Patel, Daniela Baldoni, Jennifer Lotter, Colin O. Wu, Ruba Shalhoub, Neal S. Young, Annie St. Pierre
Publikováno v:
Br J Haematol
Acquired severe aplastic anaemia (SAA) has an immune pathogenesis, and immunosuppressive therapy (IST) with anti-thymocyte globulin and cyclosporine is effective therapy. Eltrombopag (EPAG) added to standard IST was associated with higher overall and
Autor:
Darren Wilbraham, Daniela Baldoni, Maribel Reyes, Pierre-Eric Juif, Andrea Vaclavkova, Jasper Dingemanse, Matthias Hoch, Salvatore Febbraro
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2636 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2636
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2636
The pharmacokinetics, pharmacodynamics, tolerability, and food effect of cenerimod, a potent sphingosine-1-phosphate subtype 1 receptor modulator, were investigated in three sub-studies. Two double-blind, placebo-controlled, randomised studies in hea
Autor:
Daniela Baldoni, Andrej Trampuz, Filippo Galli, Violetta Iodice, Alberto Signore, Peter Bläuenstein, Roger Schibli, Robert Waibel
Publikováno v:
Molecular Imaging and Biology
Molecular Imaging and Biology, 17 (6)
Molecular Imaging and Biology, 17 (6)
Purpose: Vitamin B12 (cyanocobalamin, Cbl) is accumulated by rapidly replicating prokaryotic and eukaryotic cells. We investigated the potential of a Tc-99m labelled Cbl derivative ([99mTc]PAMA(4)-Cbl) for targeting infections caused by Escherichia c
Autor:
Sveva Auletta, Iman A. Hajar, Alberto Signore, Filippo Galli, Andrej Trampuz, Adriano Duatti, Michela Varani, Guillermina Ferro-Flores, Daniela Baldoni
Publikováno v:
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 63(1)
BACKGROUND Diagnosis of implant-associated infection is challenging. Several radiopharmaceuticals have been described but direct comparisons are limited. Here we compared in vitro and in an animal model 99mTc-UBI, 99mTc-ciprofloxacin, 99mTcN-CiproCS2
Autor:
Daniela Baldoni, Jasper Dingemanse, Pierre Gueret, Andreas Krause, Shirin Bruderer, Marcello Gutierrez, Béatrice Astruc
Publikováno v:
Clinical Drug Investigation. 34:807-818
ACT-246475 is a new reversible, selective, and potent antagonist of the platelet P2Y12 receptor. This study was a first-in-man trial investigating the tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of ACT-246475 and its di-
Autor:
Frances M. Platt, Marc Iglarz, Eric A. Ertel, Daniela Baldoni, Richard W. D. Welford, Caroline Deymier, Markus R. Probst, David A. Priestman, Andreas Mühlemann, Marco Garzotti
Publikováno v:
Molecular Genetics and Metabolism. 120:S139-S140
Fabry disease (FD) is a lysosomal disorder caused by mutations in the GLA gene coding for α‑galactosidase A (α‑GalA). These mutations lead to the accumulation of α‑GalA substrates, including globotriaosylceramide (Gb3). As a consequence of l
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1142-1148
We investigated the activity of linezolid, alone and in combination with rifampin (rifampicin), against a methicillin-resistant Staphylococcus aureus (MRSA) strain in vitro and in a guinea pig model of foreign-body infection. The MIC, minimal bacteri