Using dicationic ionic liquids to upgrade the cytotoxicity and solubility of poorly water-soluble drugs

Autor: Ana B.P. Silva, Ana R. Jesus, Daniela A.S. Agostinho, José M.S.S. Esperança, Alexandre Paiva, Ana R.C. Duarte, Patrícia M. Reis

Publikováno v: Journal of Ionic Liquids, Vol 3, Iss 1, Pp 100052- (2023)

New dicationic ionic liquids (DcILs) based on carboxylic acid-derived, N-acetyl amino acid-derived or bromide anions, and ammonium cations were synthesized and characterized. DcILs were employed as co-solvents to improve the solubility of ibuprofen a

Externí odkaz: https://doaj.org/article/490fbcfabdd1440fab399237c0b20344

Improvement of New Dianionic Ionic Liquids vs Monoanionic in Solubility of Poorly Water-Soluble Drugs

Autor: Patrícia M. Reis, José M. S. S. Esperança, Ana B.P. Silva, Ana R. Jesus, Alexandre Paiva, Ana Rita C. Duarte, Daniela A.S. Agostinho

Publikováno v: Journal of Pharmaceutical Sciences. 110:2489-2500

New ionic liquids (ILs) based on dianionic phosphonate anions and ammonium cations were prepared and characterized. They were used as excipients to increase the water solubility of two oral drugs, piroxicam and ibuprofen, that are slightly soluble in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb43a1972b9eac0820f2ad535123382
https://doi.org/10.1016/j.xphs.2021.01.014

New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs

Autor: Luís Raposo, José M. S. S. Esperança, Pedro V. Baptista, Daniela A.S. Agostinho, Patrícia M. Reis, Mário R. C. Soromenho, Alexandra R. Fernandes, Ana R. Jesus

Publikováno v: Symmetry, Vol 13, Iss 2053, p 2053 (2021)
Symmetry
Volume 13
Issue 11
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

In this work, we prepared new biocompatible N-alkyl cholinium-based ionic liquids to be used as cosolvents to improve the solubility of poorly water-soluble drugs, namely, sodium diclofenac and paracetamol. In this set of ionic liquids, we intend to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0a54462ebc85397104dd66bbb4dbf6
https://doi.org/10.3390/sym13112053

Properties of κ-carrageenan aerogels prepared by using different dissolution media and its application as drug delivery systems

Autor: Teresa Cordeiro, Carolina V. Pereira, Ana V.M. Nunes, Daniela A.S. Agostinho, Ana Matias, Isabel Fonseca, Ana I. Paninho, M. G. Ventura

Publikováno v: Materials Chemistry and Physics. 253:123290

This work reports the synthesis of kappa-carrageenan aerogels using different dissolution and crosslinking media in order to evaluate its effects on the textural properties of the matrixes and further on the drug loading and release performance. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3c57e41e5256b98b333b579993a9be4
https://doi.org/10.1016/j.matchemphys.2020.123290