Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Daniela A Grassi"'
Autor:
Janelle Drouin‐Ouellet, Shong Lau, Per Ludvik Brattås, Daniella Rylander Ottosson, Karolina Pircs, Daniela A Grassi, Lucy M Collins, Romina Vuono, Annika Andersson Sjöland, Gunilla Westergren‐Thorsson, Caroline Graff, Lennart Minthon, Håkan Toresson, Roger A Barker, Johan Jakobsson, Malin Parmar
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1117-1131 (2017)
Abstract Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This technology offers a promising shortcut for obtaining patient‐ and disease‐specific
Externí odkaz:
https://doaj.org/article/e73f830423c14f13b05bd7371e571788
Autor:
Daniela A. Grassi, Per Ludvik Brattås, Marie E. Jönsson, Diahann Atacho, Ofelia Karlsson, Sara Nolbrant, Malin Parmar, Johan Jakobsson
Publikováno v:
Heliyon, Vol 6, Iss 1, Pp e03067- (2020)
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be differentiated into many different cell types of the central nervous system. One challenge when using pluripotent stem cells is to develop robust and efficient diffe
Externí odkaz:
https://doaj.org/article/268bccbc3ef54882834da418b4bae2bb
Autor:
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E Jönsson, Pia A Johansson, Romina Vuono, Shaline V Fazal, Thomas Stoker, Bob A Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S Hébert, György Marko-Varga, Malin Parmar, Roger A Barker, Johan Jakobsson
Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667921ae8a7da270bf48986c499fbc03
https://www.repository.cam.ac.uk/handle/1810/332257
https://www.repository.cam.ac.uk/handle/1810/332257
Publikováno v:
Brain Research. 1705:43-47
TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88677da424cebfd24055c81d66518b42
https://doi.org/10.1016/j.brainres.2018.02.043
https://doi.org/10.1016/j.brainres.2018.02.043
Autor:
K.C Sharma, Horváth, Sébastien S. Hébert, Malin Parmar, György Marko-Varga, Lagerwall J, Bob A. Hersbach, Janelle Drouin-Ouellet, Roger A. Barker, Petter Storm, Patrik Johansson, Jeovanis Gil, Romina Vuono, Kenneth D. M. Harris, Melinda Rezeli, Daniela A. Grassi, Yogita Sharma, Karolina Pircs, Marie E. Jönsson, Isabelle St-Amour, Lagerström S, Johan Jakobsson, Thomas B Stoker, Raquel Garza
Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD has remained challenging, as rodent and cellular models poorly recapitulate the disease. To address this, we generated ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e319f860465633ac18adccdda66bad1
https://doi.org/10.1101/2021.03.01.433433
https://doi.org/10.1101/2021.03.01.433433
Autor:
Per Ludvik Brattås, Jenny Johansson, Daniela A. Grassi, Didier Trono, Diahann A. M. Atacho, Johan Jakobsson, Yogita Sharma, Julien Pontis, Raquel Garza, Karolina Pircs, Pia A. Johansson, PingHsun Hsieh, Marie E. Jönsson, Christopher H. Douse, Feride Eren, Evan E. Eichler
The human forebrain has expanded in size and complexity compared to that of chimpanzee despite limited changes in protein-coding genes, suggesting that gene regulation is an important driver of brain evolution. Here we identify a KRAB-ZFP transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b159c01d678423f11d214b2dfb597ece
https://doi.org/10.1101/2020.08.18.255562
https://doi.org/10.1101/2020.08.18.255562
Autor:
Anita Adami, Rodrigo Cataldo, Alessandro Fiorenzano, Malin Fex, Evan E. Eichler, Pia A. Johansson, Christopher H. Douse, Diahann A. M. Atacho, Johan Jakobsson, Raquel Garza, Daniela A. Grassi, Karolina Pircs, Yogita Sharma, Marie E. Jönsson, Edoardo Sozzi, Per Ludvik Brattås, PingHsun Hsieh, Jenny Johansson, Malin Parmar, Feride Eren, Didier Trono, Julien Pontis
Publikováno v:
Cell Stem Cell. 29:52-69.e8
The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c3c119016850ecb6701ee8b70d212a
https://doi.org/10.1016/j.stem.2021.09.008
https://doi.org/10.1016/j.stem.2021.09.008
Autor:
João de Souza Mendonça, Lorena Barros Bahia, Barbara Maria Neves Mendonça Luz, Matheus Osório Lima, Ana Paula Cecilia Braga, Tamires Costa Franco, Camila Ribeiro Cardoso, Daniela Vergilio Grassi, Leidiane de Jesus da Costa Santos, Ana Karina Rodrigues Coelho, Amanda Almeida Vieira, Tâmia Rayara Carvalho Araújo da Silva, Manuele Figueira Printes, Marcello Vieira dos Santos, Ana Carolina da Silva Borges
Publikováno v:
Research, Society and Development. 10:e233101422137
O câncer de mama ocorre quando há uma proliferação exacerbada das células, ou seja, uma multiplicação rápida e desordenada das células que pode ocorrer por fatores ambientais e genéticos. O câncer de mama destaca-se como o segundo tipo de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b27168cd0d4725631e8c0668fd8f3f8d
https://doi.org/10.33448/rsd-v10i14.22137
https://doi.org/10.33448/rsd-v10i14.22137
Autor:
Daniela A. Grassi, Per Ludvik Brattås, Marie E. Jönsson, Diahann Atacho, Ofelia Karlsson, Sara Nolbrant, Malin Parmar, Johan Jakobsson
Publikováno v:
Heliyon
Heliyon, Vol 6, Iss 1, Pp e03067-(2020)
Heliyon, Vol 6, Iss 1, Pp e03067-(2020)
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be differentiated into many different cell types of the central nervous system. One challenge when using pluripotent stem cells is to develop robust and efficient diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::05646c76ee335c9001b9bad741d2711e
https://pubmed.ncbi.nlm.nih.gov/31909251
https://pubmed.ncbi.nlm.nih.gov/31909251
Autor:
Daniela A. Grassi, Johan Jakobsson, Rezeli M, Malin Parmar, Marko-Varga G, Per Ludvik Brattås, Valdés Jg, Marie E. Jönsson, Sara Nolbrant
The forebrain has expanded in size and complexity during hominoid evolution. The contribution of post-transcriptional control of gene expression to this process is unclear. Using in-depth proteomics in combination with bulk and single-cell RNA sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0989887de1532d6e3d23e6ac20192b54
https://doi.org/10.1101/582197
https://doi.org/10.1101/582197