Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Daniela C. Popescu"'
Autor:
Daniela C Popescu, He Huang, Naveen K Singhal, Leah Shriver, Jennifer McDonough, Robert J Clements, Ernest J Freeman
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203057 (2018)
Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system. The most abundant myelin lipids are galactosylceramides and their sulfated form, sulfatides, whic
Externí odkaz:
https://doaj.org/article/5ce6b699c7154ba0814cb46b62b65ab8
Autor:
Kholoud Alkhayer, Daniela C. Popescu, Naveen Kumar Singhal, Alyx Weaver, Sheila Fleming, Robert Clements, Jennifer McDonough, John Shelestak, Teodoro Bottiglieri, Ernest J. Freeman, Sarah Sternbach, Brandi Wasek
Publikováno v:
Epigenetics
Methionine metabolism is dysregulated in multiple sclerosis (MS). The methyl donor betaine is depleted in the MS brain where it is linked to changes in levels of histone H3 trimethylated on lysine 4 (H3K4me3) and mitochondrial impairment. We investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638f2d46622d1469e75b8424bb51221f
https://doi.org/10.1080/15592294.2020.1735075
https://doi.org/10.1080/15592294.2020.1735075
Autor:
Hilary H. Sachs, Kathryn K. Bercury, Daniela C. Popescu, S. Priya Narayanan, Wendy B. Macklin
Publikováno v:
ASN Neuro, Vol 6 (2014)
In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain. One model used to understand the me
Externí odkaz:
https://doaj.org/article/bac39213b60f40aba40759873ed29a5e
Autor:
Chunying Wu, Changning Wang, Robert H. Miller, Daniela C. Popescu, Wendy B. Macklin, Junqing Zhu, Yanming Wang
Publikováno v:
The Journal of Neuroscience. 31:2382-2390
Myelination is one of the fundamental biological processes in the development of vertebrate nervous system. Disturbance of myelination is found to be associated with progression in many neurological diseases such as multiple sclerosis. Tremendous eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e0cde6f402317cef4386903b466d94
https://doi.org/10.1523/jneurosci.2698-10.2011
https://doi.org/10.1523/jneurosci.2698-10.2011
Autor:
Changning Wang, Christopher A Flask, Robert H. Miller, Chunying Wu, Junqing Zhu, Eduardo Somoza, Wenxia Zhu, Allison G. Condie, Daniela C. Popescu, Wendy B. Macklin, Yanming Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8592-8599
C-11-labeled N-methyl-4,4'-diaminostilbene ([(11)C]MeDAS) was synthesized and evaluated as a novel radiotracer for in vivo microPET imaging of myelination. [(11)C]MeDAS exhibits optimal lipophilicity for brain uptake with a logP(oct) value of 2.25. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0364d427e176320cfaa4b08e58c7c475
https://doi.org/10.1016/j.bmc.2010.10.018
https://doi.org/10.1016/j.bmc.2010.10.018
Autor:
Robert Clements, Leah P. Shriver, Jennifer McDonough, He Huang, Ernest J. Freeman, Daniela C. Popescu, Naveen Kumar Singhal
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203057 (2018)
Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system. The most abundant myelin lipids are galactosylceramides and their sulfated form, sulfatides, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d8513f506f632671283b4a4cca762f
https://doi.org/10.1371/journal.pone.0203057
https://doi.org/10.1371/journal.pone.0203057
Publikováno v:
Journal of Neurochemistry. 104:1526-1535
J. Neurochem. (2008) 104, 1526–1535. Abstract Drosophila transient-receptor-potential (TRP) is a Ca2+ channel responsible for the light-dependent depolarization of photoreceptors. TRP is anchored to a macromolecular complex by tethering to inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d1d6e0f5a982ca46c890041d8af92df
https://doi.org/10.1111/j.1471-4159.2007.05096.x
https://doi.org/10.1111/j.1471-4159.2007.05096.x
Autor:
Bpr Benoît Pichon, Najm Nico Sommerdijk, Maarten M. J. Smulders, Natalia A. Chebotareva, Sy Kwak, Rint P. Sijbesma, Daniela C. Popescu, E DiMasi, van Olj Otto Asselen
Publikováno v:
Journal of the American Chemical Society, 129(45), 14058-14067. American Chemical Society
In CaCO3, biomineralization nucleation and growth of the crystals are related to the presence of carboxylate-rich proteins within a macromolecular matrix, often with organized beta-sheet domains. To understand the interplay between the organic templa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc8e9a02913cf0e57085f913dcaa531
https://doi.org/10.1021/ja075875t
https://doi.org/10.1021/ja075875t
Publikováno v:
The Journal of Neuroscience. 26:8570-8577
Drosophilavisual signaling is one of the fastest G-protein-coupled transduction cascades, because effector and modulatory proteins are organized into a macromolecular complex (“transducisome”). Assembly of the complex is orchestrated by inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9f90074c13bcd2a992113a489000d3
https://doi.org/10.1523/jneurosci.1478-06.2006
https://doi.org/10.1523/jneurosci.1478-06.2006
Autor:
Alexander Kros, Matthijn R. J. Vos, Mark Overhand, Nico A. J. M. Sommerdijk, Silvia Cavalli, Emily E. Tellers, Hanna Rapaport, Daniela C. Popescu, Benoit P. Pichon
Publikováno v:
Angewandte Chemie-International Edition, 45(5), 739-744. Wiley
Formaterialsscientists,anunderstandingoftheprinciples underlying the process of biomineralization holdsgreat promise for the design and synthesis of new inorganicand hybrid structures with yet unrealized properties. Thecentral concept in biomineraliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248b0651ef3e9e08c3ceef032663d449
https://doi.org/10.1002/anie.200501654
https://doi.org/10.1002/anie.200501654