Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Daniela Arosio"'
Autor:
Elisa Facen, Giulia Assoni, Greta Donati, Dalila Paladino, Agata Carreira, Isabelle Bonomo, Valeria La Pietra, Roberta Lotti, Josef Houser, Luca L. Fava, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Alessandro Provenzani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The RNA binding protein Human Antigen R (HuR) has been identified as a main regulator of the innate immune response and its inhibition can lead to beneficial anti-inflammatory effects. To this aim, we previously synthesized a novel class of
Externí odkaz:
https://doaj.org/article/bdf3a13a957a4cdb8e0be0dcf65c60d7
Autor:
Greta Donati, Vincenzo Maria D’Amore, Pasquale Russomanno, Linda Cerofolini, Jussara Amato, Simona Marzano, Maria Salobehaj, Domenico Rizzo, Giulia Assoni, Alfonso Carotenuto, Valeria La Pietra, Daniela Arosio, Pierfausto Seneci, Marco Fragai, Diego Brancaccio, Francesco Saverio Di Leva, Luciana Marinelli
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3355-3368 (2023)
Today it is widely recognized that the PD-1/PD-L1 axis plays a fundamental role in escaping the immune system in cancers, so that anti-PD-1/PD-L1 antibodies have been evaluated for their antitumor properties in more than 1000 clinical trials. As a re
Externí odkaz:
https://doaj.org/article/3bd14ba4f0aa401ca2a63ca4a266835e
Autor:
Isabelle Bonomo, Giulia Assoni, Valeria La Pietra, Giulia Canarutto, Elisa Facen, Greta Donati, Chiara Zucal, Silvia Genovese, Mariachiara Micaelli, Anna Pérez-Ràfols, Sergio Robbiati, Dimitris L. Kontoyannis, Marilenia De Matteo, Marco Fragai, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Silvano Piazza, Alessandro Provenzani
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/f46f5530b8b347c99a98e099c85d727f
Autor:
Adina Borbély, Dr. Eduard Figueras, Ana Martins, Dr. Lizeth Bodero, Dr. André Raposo Moreira Dias, Dr. Paula López Rivas, Dr. Arianna Pina, Dr. Daniela Arosio, Dr. Paola Gallinari, Dr. Marcel Frese, Dr. Christian Steinkühler, Prof. Dr. Cesare Gennari, Prof. Dr. Umberto Piarulli, Prof. Dr. Norbert Sewald
Publikováno v:
ChemistryOpen, Vol 8, Iss 6, Pp 737-742 (2019)
Abstract RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable
Externí odkaz:
https://doaj.org/article/d3a79dc0bab74335b6cc1b9cbbeb2934
Autor:
Antonello Spinelli, Maria Girelli, Daniela Arosio, Laura Polito, Paola Podini, Gianvito Martino, Pierfausto Seneci, Luca Muzio, Andrea Menegon
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background The increasing use of gold nanoparticles (AuNPs) in the field of neuroscience instilled hope for their rapid translation to the clinical practice. AuNPs can be engineered to carry therapeutics or diagnostics in the diseased brain,
Externí odkaz:
https://doaj.org/article/f9a6b9b5521448cdbedd2d3ab02ad5f3
Autor:
Giulia Frapporti, Eleonora Colombo, Hazem Ahmed, Giulia Assoni, Laura Polito, Pietro Randazzo, Daniela Arosio, Pierfausto Seneci, Giovanni Piccoli
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 862 (2022)
The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor pharmacokinetic profile. Thus, we targeted the rational design and synthesis of trehalose-based small
Externí odkaz:
https://doaj.org/article/25d372ad06db48e6a52e7e969bcb2a38
Autor:
Lizeth Bodero, Paula López Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl, Christoph Müller, Daniela Arosio, Luca Pignataro, Cesare Gennari, Umberto Piarulli
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 407-415 (2018)
RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified
Externí odkaz:
https://doaj.org/article/b6aac4e1d16e4883ac5787d77551d159
Autor:
Simone Zanella, Gianfranco Bocchinfuso, Marta De Zotti, Daniela Arosio, Franca Marino, Stefano Raniolo, Luca Pignataro, Giovanni Sacco, Antonio Palleschi, Alvaro S. Siano, Umberto Piarulli, Laura Belvisi, Fernando Formaggio, Cesare Gennari, Lorenzo Stella
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which are overexpressed in cancer cells. Therefore, the VEGF/VEGFR interaction represents a promisi
Externí odkaz:
https://doaj.org/article/a4e1611d36f740098708cafea8c79c51
Autor:
Giovanni Sacco, Daniela Arosio, Mayra Paolillo, Andreas Gloger, Jörg Scheuermann, Luca Pignataro, Laura Belvisi, Alberto Dal Corso, Cesare Gennari
Publikováno v:
Chemistry-A European Journal, 29 (19)
Salicylaldehyde (SA) derivatives are emerging as useful fragments to obtain reversible-covalent inhibitors interacting with the lysine residues of the target protein. Here the SA installation at the C terminus of an integrin-binding cyclopeptide, lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb3e17944199a3240f1e4a8b4bc561d
https://hdl.handle.net/20.500.11850/604148
https://hdl.handle.net/20.500.11850/604148
Autor:
Isabelle Bonomo, Giulia Assoni, Valeria La Pietra, Giulia Canarutto, Elisa Facen, Greta Donati, Chiara Zucal, Silvia Genovese, Mariachiara Micaelli, Anna Pérez-Ràfols, Sergio Robbiati, Dimitris L. Kontoyannis, Marilenia De Matteo, Marco Fragai, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Silvano Piazza, Alessandro Provenzani
Lipopolysaccharide exposure to macrophages induces an inflammatory response that is heavily regulated at the transcriptional and post-transcriptional levels. HuR (ELAVL1) is an RNA binding protein that binds and regulates the maturation and half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41301d83518b6abcd82afc44a44b97b0
https://doi.org/10.1101/2023.01.16.524289
https://doi.org/10.1101/2023.01.16.524289