Výsledky vyhledávání - "Daniela, Verzella"

Akademický článek

EV-Mediated Chemoresistance in the Tumor Microenvironment: Is NF-κB a Player?

Autor: Mauro Di Vito Nolfi, Davide Vecchiotti, Irene Flati, Daniela Verzella, Monica Di Padova, Edoardo Alesse, Daria Capece, Francesca Zazzeroni

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Drug resistance is a major impediment to patient survival and remains the primary cause of unsuccessful cancer therapy. Drug resistance occurs in many tumors and is frequently induced by chemotherapy which triggers a defensive response both in cancer

Externí odkaz: https://doaj.org/article/f6dda65f89674c8583bac7082122c1da

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Akademický článek

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3

Publikováno v: Toxicology Reports, Vol 6, Iss , Pp 369-379 (2019)

Aberrant NF-κB activity drives oncogenesis and cell survival in multiple myeloma (MM) and many other cancers. However, despite an aggressive effort by the pharmaceutical industry over the past 30 years, no specific IκBα kinase (IKK)β/NF-κB inhib

Externí odkaz: https://doaj.org/article/2bef177c9ad24c388d8e263481c9368e

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Akademický článek

The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target

Autor: Daniela Verzella, Jessica Cornice, Paola Arboretto, Davide Vecchiotti, Mauro Di Vito Nolfi, Daria Capece, Francesca Zazzeroni, Guido Franzoso

Publikováno v: Biomedicines, Vol 10, Iss 9, p 2233 (2022)

NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB signaling is constitutively activated by genetic alterations or environmental signals in many human cancers, where it contributes to almost all hallmarks of ma

Externí odkaz: https://doaj.org/article/7e5eaff61d704563be5a56672d26381b

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Akademický článek

Elevated NF-κB/SHh/GLI1 Signature Denotes a Worse Prognosis and Represent a Novel Potential Therapeutic Target in Advanced Prostate Cancer

Autor: Davide Vecchiotti, Daniela Verzella, Mauro Di Vito Nolfi, Daniel D’Andrea, Irene Flati, Barbara Di Francesco, Jessica Cornice, Edoardo Alesse, Daria Capece, Francesca Zazzeroni

Publikováno v: Cells, Vol 11, Iss 13, p 2118 (2022)

Prostate cancer (PCa) is the second most frequent cancer in men worldwide. NF-κB seems to play a key role in cell survival, proliferation and invasion, sustaining the heterogeneous multifocal nature of PCa. In recent years, the Hedgehog (Hh) signali

Externí odkaz: https://doaj.org/article/2e8b7bc8be24413cb898daa982a25a74

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Akademický článek

Low Radiation Environment Switches the Overgrowth-Induced Cell Apoptosis Toward Autophagy

Autor: Mariafausta Fischietti, Emiliano Fratini, Daniela Verzella, Davide Vecchiotti, Daria Capece, Barbara Di Francesco, Giuseppe Esposito, Marco Balata, Luca Ioannuci, Pamela Sykes, Luigi Satta, Francesca Zazzeroni, Alessandra Tessitore, Maria Antonella Tabocchini, Edoardo Alesse

Publikováno v: Frontiers in Public Health, Vol 8 (2021)

Low radiation doses can affect and modulate cell responses to various stress stimuli, resulting in perturbations leading to resistance or sensitivity to damage. To explore possible mechanisms taking place at an environmental radiation exposure, we se

Externí odkaz: https://doaj.org/article/4fbc572e0a8649c7b96463f9c3fb8051

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Figure S2 from GADD45β Loss Ablates Innate Immunosuppression in Cancer

Increased TLS Formation, Macrophage Infiltration and Proinflammatory TAM Activation in HCCs from Gadd45b-/- Mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d6f06e78e9ba6c12f11c5d54bb6986
https://doi.org/10.1158/0008-5472.22412129.v1

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Supplementary information from GADD45β Loss Ablates Innate Immunosuppression in Cancer

Supplemental Figure Legends and Supplementary Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4f01ba137904ec86b58c77c7d10618
https://doi.org/10.1158/0008-5472.22412108

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Data from GADD45β Loss Ablates Innate Immunosuppression in Cancer

T-cell exclusion from the tumor microenvironment (TME) is a major barrier to overcoming immune escape. Here, we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumor-associated inflammation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e828ff61e1f797bda99751fceb2c52c0
https://doi.org/10.1158/0008-5472.c.6508367.v1

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NF-κB: blending metabolism, immunity, and inflammation

Autor: Daria Capece, Daniela Verzella, Irene Flati, Paola Arboretto, Jessica Cornice, Guido Franzoso

The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd7930f31c49a508560fa5cfc29c4ee
https://hdl.handle.net/11697/199081

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