Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Daniela, Verthelyi"'
Autor:
Brian J. Roberts, Aimee E. Mattei, Kristina E. Howard, James L. Weaver, Hao Liu, Sandra Lelias, William D. Martin, Daniela Verthelyi, Eric Pang, Katie J. Edwards, Anne S. De Groot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Advances in synthetic peptide synthesis have enabled rapid and cost-effective peptide drug manufacturing. For this reason, peptide drugs that were first produced using recombinant DNA (rDNA) technology are now being produced using solid- and liquid-p
Externí odkaz:
https://doaj.org/article/674dd4b85a844bff9f2eb55deb7c7e13
Autor:
Ha-Na Lee, Biying Xu, Aaron P. Lewkowicz, Kaliroi Engel, Logan Kelley-Baker, Ian L. McWilliams, Derek D.C. Ireland, Jennifer L. Kielczewski, Jinbo Li, Robert N. Fariss, Mercedes M. Campos, Alina Baum, Christos Kyratsous, Kristen Pascal, Chi-Chao Chan, Rachel R. Caspi, Mohanraj Manangeeswaran, Daniela Verthelyi
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105170- (2024)
Summary: Background: Ebola virus disease (EVD) survivors experience ocular sequelae including retinal lesions, cataracts, and vision loss. While monoclonal antibodies targeting the Ebola virus glycoprotein (EBOV-GP) have shown promise in improving pr
Externí odkaz:
https://doaj.org/article/22fa242296984e11a7988fdc6dae6cdd
Autor:
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulate
Externí odkaz:
https://doaj.org/article/a86a14995f034dc4b2346857bdc3f017
Autor:
Ta-Chung M. Mou, Malcolm V. Lane, Derek D.C. Ireland, Daniela Verthelyi, Leonardo H. Tonelli, Sarah M. Clark
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105840- (2022)
An early inflammatory insult is the most recognized risk factor associated with neurodevelopmental psychiatric disorders, even more so than genetic variants. Notably, complement component 4 (C4), a molecule involved in inflammatory responses, has bee
Externí odkaz:
https://doaj.org/article/d110f1ad1f01476dbed0fb4f4eb11dda
Autor:
Seth G. Thacker, Cheng Her, Logan Kelley-Baker, Derek D C. Ireland, Mohanraj Manangeeswaran, Eric S. Pang, Daniela Verthelyi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Unintended immunogenicity can affect the safety and efficacy of therapeutic proteins and peptides, so accurate assessments of immunogenicity risk can aid in the selection, development, and regulation of biologics. Product- and process- related impuri
Externí odkaz:
https://doaj.org/article/12c252eade24479d8194d84845fe9d06
Autor:
Mohanraj Manangeeswaran, Derek D. C. Ireland, Seth G. Thacker, Ha-Na Lee, Logan Kelley-Baker, Aaron P. Lewkowicz, Paul W. Rothlauf, Marjorie Cornejo Pontelli, Louis-Marie Bloyet, Michael A. Eckhaus, Mirian I. Mendoza, Sean Whelan, Daniela Verthelyi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading to successive wav
Externí odkaz:
https://doaj.org/article/deaaeda822cd4fe79b79fccbec48b68b
Autor:
Ha-Na Lee, Ian L. McWilliams, Aaron P. Lewkowicz, Kaliroi Engel, Derek D. C. Ireland, Logan Kelley-Baker, Seth Thacker, Pedro Piccardo, Mohanraj Manangeeswaran, Daniela Verthelyi
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2076-2089 (2021)
Ebola virus (EBOV) infections cause haemorrhagic fever, multi-organ failure and death, and survivors can experience neurological sequelae. Licensing of monoclonal antibodies targeting EBOV glycoprotein (EBOV-GP) improved its prognosis, however, this
Externí odkaz:
https://doaj.org/article/d872a120c2254056bd329b2d88e1c4f7
Autor:
Ha-Na Lee, Mohanraj Manangeeswaran, Aaron P. Lewkowicz, Kaliroi Engel, Monica Chowdhury, Mamatha Garige, Michael A. Eckhaus, Carole Sourbier, Derek D.C. Ireland, Daniela Verthelyi
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Immune cells express an array of inhibitory checkpoint receptors that are upregulated upon activation and limit tissue damage associated with excessive response to pathogens or allergens. Mouse leukocyte immunoglobulin like receptor B4 (LILRB4), also
Externí odkaz:
https://doaj.org/article/ed586e07f74c46d2b1ffedf5bb2ac318
Autor:
Derek D C Ireland, Mohanraj Manangeeswaran, Aaron P Lewkowicz, Kaliroi Engel, Sarah M Clark, Adelle Laniyan, Jacob Sykes, Ha-Na Lee, Ian L McWilliams, Logan Kelley-Baker, Leonardo H Tonelli, Daniela Verthelyi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1008689 (2020)
The neurodevelopmental defects associated with ZIKV infections early in pregnancy are well documented, however the potential defects and long-term consequences associated with milder infections in late pregnancy and perinatal period are less well und
Externí odkaz:
https://doaj.org/article/7b3063f6a3ea4b5b8cea67ce814cc095
Autor:
Seth G Thacker, Ian L McWilliams, Beatrice Bonnet, Lydia Halie, Serge Beaucage, Swaksha Rachuri, Ranadhir Dey, Robert Duncan, Farrokh Modabber, Stephen Robinson, Graeme Bilbe, Byron Arana, Daniela Verthelyi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0008050 (2020)
Cutaneous leishmaniasis (CL) affects the lives of 0.7-1 million people every year causing lesions that take months to heal. These lesions can result in disfiguring scars with psychological, social and economic consequences. Antimonials are the first
Externí odkaz:
https://doaj.org/article/d7284f9e62384f2481e13e85f6fb0f68