Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniela, Tomaselli"'
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Sirtuins are NAD+-dependent deacylases that play crucial roles in the regulation of cellular metabolism, and as a result, are implicated in several diseases. The mitochondrial sirtuin Sirt4, for a long time considered as mainly a mono-ADP-ribosyltran
Externí odkaz:
https://doaj.org/article/40c9cb1ce54c419180e588e206bfb4bc
Autor:
Nicola Baldini, Claudiu T. Supuran, Francesca Perut, Alessia Lucidi, Paola Gratteri, Antonello Mai, Alessio Nocentini, Daniela Tomaselli, Dante Rotili, Annamaria Massa
Publikováno v:
ACS Medicinal Chemistry Letters. 10:661-665
Among human carbonic anhydrase (CA) inhibitors, the alpha,gamma-diketocarboxylic acids and esters are still poorly investigated. Here, we report the first compounds of this class (1-6) acting as potent inhibitors at low nanomolar level against the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bd3a21690772a20f6f0dad81c05dc0
https://doi.org/10.1021/acsmedchemlett.9b00023
https://doi.org/10.1021/acsmedchemlett.9b00023
Autor:
Carmela Fimognari, Chiara Marchetti, Eleonora Turrini, Vincenzo Tumiatti, Daniela Tomaselli, Roberta Mazzone, Elena Catanzaro, Anna Minarini, Andrea Milelli
Epigenetic modulators Histone deacetylases (HDACs) and Lysine demethylase (LSD1) are validated targets for anticancer therapy. Both HDAC1/2 and LSD1 are found in association with the repressor protein CoREST in a transcriptional co-repressor complex,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202dc63b2cc16b93d7b437aecdc96c23
http://hdl.handle.net/11585/630661
http://hdl.handle.net/11585/630661
Autor:
Daria, Monaldi, Dante, Rotili, Julien, Lancelot, Martin, Marek, Nathalie, Wössner, Alessia, Lucidi, Daniela, Tomaselli, Elizabeth, Ramos-Morales, Christophe, Romier, Raymond J, Pierce, Antonello, Mai, Manfred, Jung
Publikováno v:
Journal of medicinal chemistry. 62(19)
The only drug currently available for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary and urgent. To this end, the targeting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ec21040e92d40996e35c3f07a830dd4
https://pubmed.ncbi.nlm.nih.gov/31496251
https://pubmed.ncbi.nlm.nih.gov/31496251
Autor:
Raymond J. Pierce, Nathalie Wössner, Christophe Romier, Elizabeth Ramos-Morales, Daria Monaldi, Antonello Mai, Dante Rotili, Manfred Jung, Alessia Lucidi, Julien Lancelot, Daniela Tomaselli, Martin Marek
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (19), pp.8733-8759. ⟨10.1021/acs.jmedchem.9b00638⟩
Journal of Medicinal Chemistry, 2019, 62 (19), pp.8733-8759. ⟨10.1021/acs.jmedchem.9b00638⟩
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (19), pp.8733-8759. ⟨10.1021/acs.jmedchem.9b00638⟩
Journal of Medicinal Chemistry, 2019, 62 (19), pp.8733-8759. ⟨10.1021/acs.jmedchem.9b00638⟩
The standard drug for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance to this treatment makes the research on novel therapeutic agents necessary and urgent. To this end, the targeting of Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f590f6837f9fd9369c77a49ed274ed34
https://doi.org/10.26434/chemrxiv.7957544.v1
https://doi.org/10.26434/chemrxiv.7957544.v1
Autor:
Emmanuele Crespan, Giovanni Maga, Roberto Cirilli, Antonello Mai, Cristina Panella, Mariantonietta Forgione, Alessia Lucidi, Ivan A Kirillov, Rino Ragno, Eva Riveira-Muñoz, Alexandros Patsilinakos, Roger Badia, José A. Esté, M. B. Nawrozkij, Dante Rotili, Gebremedhin Solomon Hailu, Jorge I. Armijos Rivera, Daniela Tomaselli, Alexandre S. Yablokov
Conformational restriction applied to dihydrobenzylpyrimidin-4-(3 H)-ones (DABOs) by the intoduction of a methyl group at the α-benzylic position is known to massively improve the anti-HIV-1 activity of these compounds. Here, we report the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e062e9892982201c1b9fd3bc2ef101
http://hdl.handle.net/11573/1221842
http://hdl.handle.net/11573/1221842
Autor:
Marzia Di Donato, Daniela Tomaselli, Dante Rotili, Angela Nebbioso, Lucia Altucci, Alfonso Baldi, Gabriella Castoria, Elham Safadeh, Zhijun Yu, Pia Giovannelli, Angelita Poziello, Laura Della Torre, Antonello Mai, Vincenzo Carafa
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 22
Volume 20
Issue 22
Sirtuins, a family of nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylases, are promising targets for anticancer treatment. Recently, we characterized a novel pan-sirtuin (SIRT) inhibitor, MC2494, displaying antiproliferative effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782fe2eb21747c99ee3ba3e58496d36b
http://hdl.handle.net/11591/420028
http://hdl.handle.net/11591/420028
Publikováno v:
RNA Technologies ISBN: 9783030147914
The alteration of the DNA methylation pattern is often related to the onset of diseases based on epigenetic dysregulation, primarily cancer. In this scenery the development of DNA methyltransferase inhibitors is one of the most attractive challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c017e155bdc39eebb40ee2cbee506dda
https://doi.org/10.1007/978-3-030-14792-1_12
https://doi.org/10.1007/978-3-030-14792-1_12
Publikováno v:
European Journal of Medicinal Chemistry. 207:112750
PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules that trigger the poly-ubiquitination of the protein of interest (POI) inducing its degradation via the recruitment of the ubiquitin-proteasome system, thus suppressing the POI'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93b743430e99d1ff62756641b7c8d7a
https://doi.org/10.1016/j.ejmech.2020.112750
https://doi.org/10.1016/j.ejmech.2020.112750