Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Daniela, Secci"'
Autor:
Ilaria Laudadio, Beatrice Leter, Francesca Palone, Salvatore Cucchiara, Claudia Carissimi, Noemi Scafa, Daniela Secci, Roberta Vitali, Laura Stronati
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 10, Pp n/a-n/a (2024)
Abstract Objective and Rationale Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, manifests with chronic intestinal inflammation and frequent sequential fibrosis. Current pharmacological therapies may show harmful side ef
Externí odkaz:
https://doaj.org/article/33e90df3b48c4e7092d57f3137d20f53
Autor:
Daniela Secci, Erica Sanna, Simona Distinto, Alessia Onali, Antonio Lupia, Laura Demuru, Giulia Atzeni, Rita Meleddu, Filippo Cottiglia, Andrea Angeli, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Molecules, Vol 29, Iss 18, p 4444 (2024)
Human Carbonic Anhydrases (hCA) are enzymes that contribute to cancer’s development and progression. Isoforms IX and XII have been identified as potential anticancer targets, and, more specifically, hCA IX is overexpressed in hypoxic tumor cells, w
Externí odkaz:
https://doaj.org/article/df5f80cd728340e8a291dc5da994202e
Autor:
Paolo Guglielmi, Gaia Pulitelli, Francesca Arrighi, Daniela Secci, Marco Pierini, Roberto Cirilli
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 696 (2024)
Mebendazole (MBZ) is a benzimidazole carbamate anthelmintic used worldwide for the treatment and prevention of parasitic disorders in animals and humans. A large number of in vivo and in vitro studies have demonstrated that MBZ also has anticancer ac
Externí odkaz:
https://doaj.org/article/e2c8ed2168bb4c71a89749d93b5843c5
Autor:
Lisa Sequeira, Simona Distinto, Rita Meleddu, Marco Gaspari, Andrea Angeli, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Fernanda Borges, Eugenio Uriarte, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Tumour associated carbonic anhydrases (CAs) IX and XII have been recognised as potential targets for the treatment of hypoxic tumours. Therefore, considering the high pharmacological potential of the chromene scaffold as selective ligand of the IX an
Externí odkaz:
https://doaj.org/article/608a90cbda4941e490d99c961256b83c
Autor:
Emanuela Berrino, Simone Carradori, Fabrizio Carta, Francesco Melfi, Marialucia Gallorini, Giulio Poli, Tiziano Tuccinardi, José G. Fernández-Bolaños, Óscar López, Jacobus P. Petzer, Anél Petzer, Paolo Guglielmi, Daniela Secci, Claudiu T. Supuran
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2044 (2023)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial etiology. The most common NDs are Alzheimer’s disease and Parkinson’s disease, in which cholinergic and dopaminergic sys
Externí odkaz:
https://doaj.org/article/b5a1744f71ab47be8afc72bbec67ca7a
Publikováno v:
Molecules, Vol 28, Iss 18, p 6518 (2023)
Isoxazoline is a nitrogen- and oxygen-containing five-membered heterocyclic scaffold with diverse biological profiles such as antimicrobial, fungicidal, anticancer, antiviral, analgesic and anti-inflammatory activity. Accordingly, the use of this pec
Externí odkaz:
https://doaj.org/article/f2cc48b8db774d2da9a00874546cdc13
Autor:
Andrej Emanuel Cotman, Thomas Guérin, Ivana Kovačević, Davide Benedetto Tiz, Martina Durcik, Federica Fulgheri, Štefan Možina, Daniela Secci, Maša Sterle, Janez Ilaš, Anamarija Zega, Nace Zidar, Lucija Peterlin Mašič, Tihomir Tomašič, Frédéric R. Leroux, Gilles Hanquet, Danijel Kikelj
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9723-9730 (2021)
Externí odkaz:
https://doaj.org/article/9ba5d039df7149c1b22ceb9e931835a8
Autor:
Rita Meleddu, Serenella Deplano, Elias Maccioni, Francesco Ortuso, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Andrea Angeli, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Simona Distinto
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 685-692 (2021)
A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carboni
Externí odkaz:
https://doaj.org/article/b4e1f0d1e7d5471eb96942409fad975f
Autor:
Marta Di Martile, Chiara Gabellini, Marianna Desideri, Marta Matraxia, Valentina Farini, Elisabetta Valentini, Simone Carradori, Cristiana Ercolani, Simonetta Buglioni, Daniela Secci, Massimiliano Andreazzoli, Donatella Del Bufalo, Daniela Trisciuoglio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-14 (2020)
Abstract Background Understanding the signalling pathways involved in angiogenesis, and developing anti-angiogenic drugs are one of the major focuses on cancer research. Herein, we assessed the effect of CPTH6, a lysine acetyltransferase inhibitor an
Externí odkaz:
https://doaj.org/article/2931084bd4cc42b489a191825c894f44
Autor:
Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1891-1905 (2020)
A large library of saccharin and acesulfame derivatives has been synthesised and evaluated against four isoforms of human carbonic anhydrase, the two off-targets hCA I/II and the tumour related isoforms hCA IX/XII. Different strategies of scaffold mo
Externí odkaz:
https://doaj.org/article/78a54a75d73d42d58de2a564f1317cc7