Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Daniela, S Gerhard"'
Autor:
Justin P. Whalley, Ivo Buchhalter, Esther Rheinbay, Keiran M. Raine, Miranda D. Stobbe, Kortine Kleinheinz, Johannes Werner, Sergi Beltran, Marta Gut, Daniel Hübschmann, Barbara Hutter, Dimitri Livitz, Marc D. Perry, Mara Rosenberg, Gordon Saksena, Jean-Rémi Trotta, Roland Eils, Daniela S. Gerhard, Peter J. Campbell, Matthias Schlesner, Ivo G. Gut
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Working with cancer genomes from multiple projects can increase investigative power, but quality of sequences can vary. Here, the authors present a framework for comparing whole genome sequencing quality to help researchers guide downstream analyses
Externí odkaz:
https://doaj.org/article/ba676c81737441b295bb24df190a545c
Autor:
Hye-Jung E. Chun, Pascal D. Johann, Katy Milne, Marc Zapatka, Annette Buellesbach, Naveed Ishaque, Murat Iskar, Serap Erkek, Lisa Wei, Basile Tessier-Cloutier, Jake Lever, Emma Titmuss, James T. Topham, Reanne Bowlby, Eric Chuah, Karen L. Mungall, Yussanne Ma, Andrew J. Mungall, Richard A. Moore, Michael D. Taylor, Daniela S. Gerhard, Steven J.M. Jones, Andrey Korshunov, Manfred Gessler, Kornelius Kerl, Martin Hasselblatt, Michael C. Frühwald, Elizabeth J. Perlman, Brad H. Nelson, Stefan M. Pfister, Marco A. Marra, Marcel Kool
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2338-2354.e7 (2019)
Summary: Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we a
Externí odkaz:
https://doaj.org/article/f387a818dece4658893038403fb02a1d
Autor:
Soheil Meshinchi, Daniela S. Gerhard, Malcolm A. Smith, David A. Wheeler, Alan S. Gamis, Lora R. Lewis, Navin Rustagi, Ninad Dewal, Donna M. Muzny, Leandro Hermida, Patee Gesuwan, Tanja M. Davidsen, Jaime M. Guidry Auvil, Todd A. Alonzo, Lisa R. Trevino, Oliver A. Hampton, Daniel Wai, Rhonda E. Ries, Heather L. Schuback, Jason E. Farrar
Demographic Information of Patient Cohort. A) Age category of patients. B) Cytogenetic category.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5073cf6db09b01277dbc1eb3e614631c
https://doi.org/10.1158/0008-5472.22410521.v1
https://doi.org/10.1158/0008-5472.22410521.v1
Autor:
Soheil Meshinchi, Daniela S. Gerhard, Malcolm A. Smith, David A. Wheeler, Alan S. Gamis, Lora R. Lewis, Navin Rustagi, Ninad Dewal, Donna M. Muzny, Leandro Hermida, Patee Gesuwan, Tanja M. Davidsen, Jaime M. Guidry Auvil, Todd A. Alonzo, Lisa R. Trevino, Oliver A. Hampton, Daniel Wai, Rhonda E. Ries, Heather L. Schuback, Jason E. Farrar
Patient Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1730c4808a820a6068d5be1f2e47d6
https://doi.org/10.1158/0008-5472.22410509
https://doi.org/10.1158/0008-5472.22410509
Autor:
Elizabeth J. Perlman, Julie M. Gastier-Foster, Nicole Ross, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Amy L. Walz, Oliver A. Hampton, David A. Wheeler, Jing Ma, Charles G. Mullighan, James I. Geller, Jing Tian, Yueh-Yun Chi, Jeffrey S. Dome, Vicki Huff, Marco A. Marra, Richard A. Moore, Andrew J. Mungall, Zusheng Zong, Yussanne Ma, Ying Hu, Cu Nguyen, Chunhua Yan, Chih Hao Hsu, Qing-Rong Chen, Daoud Meerzaman, Jaime M. Guidry Auvil, Malcolm A. Smith, Daniela S. Gerhard, Samantha Gadd, Ariadne H.A.G. Ooms
Purpose: To investigate the role and significance of TP53 mutation in diffusely anaplastic Wilms tumors (DAWTs).Experimental Design: All DAWTs registered on National Wilms Tumor Study-5 (n = 118) with available samples were analyzed for TP53 mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e5ffc41c18b2d4c2506525d3dba9a1
https://doi.org/10.1158/1078-0432.c.6524982
https://doi.org/10.1158/1078-0432.c.6524982
Autor:
Elizabeth J. Perlman, Julie M. Gastier-Foster, Nicole Ross, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Amy L. Walz, Oliver A. Hampton, David A. Wheeler, Jing Ma, Charles G. Mullighan, James I. Geller, Jing Tian, Yueh-Yun Chi, Jeffrey S. Dome, Vicki Huff, Marco A. Marra, Richard A. Moore, Andrew J. Mungall, Zusheng Zong, Yussanne Ma, Ying Hu, Cu Nguyen, Chunhua Yan, Chih Hao Hsu, Qing-Rong Chen, Daoud Meerzaman, Jaime M. Guidry Auvil, Malcolm A. Smith, Daniela S. Gerhard, Samantha Gadd, Ariadne H.A.G. Ooms
This table shows the recurrent mutations that were identified as well as the gains/losses at previously reported chromosomal segments in the 39 DAWTs that were selected for in-depth analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc0f1178c491c1b33e2675cd9e5a8d5
https://doi.org/10.1158/1078-0432.22462011
https://doi.org/10.1158/1078-0432.22462011
Autor:
Javed Khan, John M. Maris, Robert Seeger, Paul M. Sondel, Stephen M. Hewitt, Daniel Catchpoole, Aysen Yuksel, Daniela S. Gerhard, Jaime M. Guidry Auvil, Ashley Walton, Sushma Najaraj, Rajesh Patidar, Xinyu Wen, Sivasish Sindiri, Shahab Asgharzadeh, Young K. Song, Shile Zhang, Igor B. Kuznetsov, Jun S. Wei
Supplementary Table S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3871fb9a5d46e60a7df44fc9f04eeea2
https://doi.org/10.1158/1078-0432.22470804
https://doi.org/10.1158/1078-0432.22470804
Autor:
Soheil Meshinchi, Daniela S. Gerhard, Malcolm A. Smith, David A. Wheeler, Alan S. Gamis, Lora R. Lewis, Navin Rustagi, Ninad Dewal, Donna M. Muzny, Leandro Hermida, Patee Gesuwan, Tanja M. Davidsen, Jaime M. Guidry Auvil, Todd A. Alonzo, Lisa R. Trevino, Oliver A. Hampton, Daniel Wai, Rhonda E. Ries, Heather L. Schuback, Jason E. Farrar
List of all segment variations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21d77850adb8344d7aeb4f0c594fc83
https://doi.org/10.1158/0008-5472.22410503
https://doi.org/10.1158/0008-5472.22410503
Autor:
Soheil Meshinchi, Daniela S. Gerhard, Malcolm A. Smith, David A. Wheeler, Alan S. Gamis, Lora R. Lewis, Navin Rustagi, Ninad Dewal, Donna M. Muzny, Leandro Hermida, Patee Gesuwan, Tanja M. Davidsen, Jaime M. Guidry Auvil, Todd A. Alonzo, Lisa R. Trevino, Oliver A. Hampton, Daniel Wai, Rhonda E. Ries, Heather L. Schuback, Jason E. Farrar
Clonal cluster analysis. Mutations were clustered using DBSCAN based on the VAF and graphed according to timepoint. Panels A-T illustrate possible scenarios of how individual mutations may originate, evolve, and resolve based on VAF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa9f69b815765f6fabdb41f9b5be176
https://doi.org/10.1158/0008-5472.22410512
https://doi.org/10.1158/0008-5472.22410512
Autor:
Elizabeth J. Perlman, Julie M. Gastier-Foster, Nicole Ross, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Amy L. Walz, Oliver A. Hampton, David A. Wheeler, Jing Ma, Charles G. Mullighan, James I. Geller, Jing Tian, Yueh-Yun Chi, Jeffrey S. Dome, Vicki Huff, Marco A. Marra, Richard A. Moore, Andrew J. Mungall, Zusheng Zong, Yussanne Ma, Ying Hu, Cu Nguyen, Chunhua Yan, Chih Hao Hsu, Qing-Rong Chen, Daoud Meerzaman, Jaime M. Guidry Auvil, Malcolm A. Smith, Daniela S. Gerhard, Samantha Gadd, Ariadne H.A.G. Ooms
This table shows all TP53 variant that were identified by Whole Genome or Exome Sequencing in all DAWTs included in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f33114e201af8a81e3df21d845e274
https://doi.org/10.1158/1078-0432.22462017.v1
https://doi.org/10.1158/1078-0432.22462017.v1