Calcium-sensing receptor in GtoPdb v.2023.1

Autor: Polina Yarova, Donald T. Ward, Dolores Shoback, Daniela Riccardi, Katie Leach, Fadil Hannan, Arthur Conigrave, Wenhan Chang, Edward M. Brown, Hans Bräuner-Osborne, Daniel Bikle

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2023

The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [47] and subsequently updated [77]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ab1d0f9a0d30c4b27c50dcb515e71af
https://doi.org/10.2218/gtopdb/f12/2023.1

Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

Autor: Martin Schepelmann, Marianna Ranieri, Irene Lopez-Fernandez, Thomas S. Webberley, Sarah C. Brennan, Polina L. Yarova, Joao Graca, Umar-Khetaab Hanif, Christian Müller, Teresa Manhardt, Martina Salzmann, Helen Quasnichka, Sally A. Price, Donald T. Ward, Thierry Gilbert, Vladimir V. Matchkov, Robert A. Fenton, Amanda Herberger, Jenna Hwong, Christian Santa Maria, Chia-Ling Tu, Enikö Kallay, Giovanna Valenti, Wenhan Chang, Daniela Riccardi

Publikováno v: J Am Soc Nephrol
Schepelmann, M, Ranieri, M, Lopez-Fernandez, I, Webberley, T S, Brennan, S C, Yarova, P L, Graca, J, Hanif, U-K, Müller, C, Manhardt, T, Salzmann, M, Quasnichka, H, Price, S A, Ward, D T, Gilbert, T, Matchkov, V V, Fenton, R A, Herberger, A, Hwong, J, Santa Maria, C, Tu, C-L, Kallay, E, Valenti, G, Chang, W & Riccardi, D 2022, ' Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 7, pp. 1323-1340 . https://doi.org/10.1681/ASN.2021040585
Schepelmann, M, Ranieri, M, Lopez-Fernandez, I, Webberley, T S, Brennan, S C, Yarova, P L, Graca, J, Hanif, U-K, Müller, C, Manhardt, T, Salzmann, M, Quasnichka, H, Price, S A, Ward, D T, Gilbert, T, Matchkov, V V, Fenton, R A, Herberger, A, Hwong, J, Santa Maria, C, Tu, C-L, Kallay, E, Valenti, G, Chang, W & Riccardi, D 2022, ' Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells ', Journal of the American Society of Nephrology : JASN . https://doi.org/10.1681/ASN.2021040585

BACKGROUND: Impaired mineral ion metabolism is a hallmark of CKD-metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a80a8762e559e8d9063bbc47564db68
https://europepmc.org/articles/PMC9257819/

Calcium-sensing receptor in GtoPdb v.2021.3

Autor: Polina Yarova, Daniel D. Bikle, Donald T. Ward, Edward M. Brown, Dolores M. Shoback, Fadil Hannan, Hans Bräuner-Osborne, Daniela Riccardi, Arthur D. Conigrave, Katie Leach, Wenhan Chang

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2021

The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [47] and subsequently updated [77]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::956aeea62502e61d520d1710f9555226
https://doi.org/10.2218/gtopdb/f12/2021.3

Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels.

Autor: Sarah C Brennan, Brenda A Finney, Maria Lazarou, Anne E Rosser, Caroline Scherf, Dirk Adriaensen, Paul J Kemp, Daniela Riccardi

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80294 (2013)

Airway branching morphogenesis in utero is essential for optimal postnatal lung function. In the fetus, branching morphogenesis occurs during the pseudoglandular stage (weeks 9-17 of human gestation, embryonic days (E)11.5-16.5 in mouse) in a hyperca

Externí odkaz: https://doaj.org/article/a3992367cf884c8992808814a86c0540

Calcium-sensing receptor antagonists, calcilytics, prevent activation of human dendritic and epithelial cells by urban particulate matter

Autor: David R Thickett, Bethan Mansfield, Ian Mudway, Tzer-Ren Ho, Luis A. J. Mur, Paul J. Kemp, Zoe Cariad Prytherch, Daniela Riccardi, Simon Scofield, Sebastian T Lugg, Christopher Corrigan, Jeremy P.T. Ward, Catherine M. Hawrylowicz, Keir Lewis

Publikováno v: Airway cell biology and immunopathology.

Introduction: Previously we have shown that blockers of the calcium-sensing receptor (CaSR, calcilytics), reduce BHR, inflammation and remodelling in Th2/IgE- and alarmin-driven asthma models. Exposure to urban particulate matter (UPM) exacerbates as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43107c9c3f8b396ff9aa2a7098c394fb
https://doi.org/10.1183/13993003.congress-2020.1970