Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Daniela, Ostermeier"'
Autor:
Ulrich Hommel, Konstanze Hurth, Jean-Michel Rondeau, Anna Vulpetti, Daniela Ostermeier, Andreas Boettcher, Jacob Peter Brady, Michael Hediger, Sylvie Lehmann, Elke Koch, Anke Blechschmidt, Rina Yamamoto, Valentina Tundo Dottorello, Sandra Haenni-Holzinger, Christian Kaiser, Philipp Lehr, Andreas Lingel, Luca Mureddu, Christian Schleberger, Jutta Blank, Paul Ramage, Felix Freuler, Joerg Eder, Frédéric Bornancin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Human interleukin-1β (hIL-1β) is a pro-inflammatory cytokine involved in many diseases. While hIL-1β directed antibodies have shown clinical benefit, an orally available low-molecular weight antagonist is still elusive, limiting the appli
Externí odkaz:
https://doaj.org/article/045a20bdd9464a2d8a11a51d75b0961e
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870
https://doi.org/10.1021/acs.jmedchem.9b01870
Autor:
Eva Altmann, Paul Erbel, Martin Renatus, Michael Schaefer, Anita Schlierf, Adelaide Druet, Laurence Kieffer, Mickael Sorge, Keith Pfister, Ulrich Hassiepen, Matthew Jones, Simon Ruedisser, Daniela Ostermeier, Bruno Martoglio, Anne B. Jefferson, Jean Quancard
Publikováno v:
Angewandte Chemie. 129:1314-1317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::163cb1ecf2b637f4dfbede7a42685a9b
https://doi.org/10.1002/ange.201608672
https://doi.org/10.1002/ange.201608672
Autor:
Simon Ruedisser, Bruno Martoglio, Michael Schaefer, Paul Erbel, Laurence Kieffer, Ulrich Hassiepen, Anita Schlierf, Martin Renatus, Mickael Sorge, Daniela Ostermeier, Adelaide Druet, Jean Quancard, Matthew Jones, Anne B. Jefferson, Keith B. Pfister, Eva Altmann
Publikováno v:
Angewandte Chemie (International ed. in English). 56(5)
CSN5 is the zinc metalloprotease subunit of the COP9 signalosome (CSN), which is an important regulator of cullin-RING E3 ubiquitin ligases (CRLs). CSN5 is responsible for the cleavage of NEDD8 from CRLs, and blocking deconjugation of NEDD8 traps the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4862fe6857b71e15cb77777154bdd6
https://pubmed.ncbi.nlm.nih.gov/27981705
https://pubmed.ncbi.nlm.nih.gov/27981705