Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Daniela, Nasteska"'
Autor:
Federica Cuozzo, Katrina Viloria, Ali H. Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Jason Tong, Zicong Jiao, Adam Boufersaoui, Bryan Marzullo, Daniel B. Rosoff, Hannah R. Smith, Caroline Bonner, Julie Kerr-Conte, Francois Pattou, Rita Nano, Lorenzo Piemonti, Paul R.V. Johnson, Rebecca Spiers, Jennie Roberts, Gareth G. Lavery, Anne Clark, Carlo D.L. Ceresa, David W. Ray, Leanne Hodson, Amy P. Davies, Guy A. Rutter, Masaya Oshima, Raphaël Scharfmann, Matthew J. Merrins, Ildem Akerman, Daniel A. Tennant, Christian Ludwig, David J. Hodson
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114047- (2024)
Summary: Using 13C6 glucose labeling coupled to gas chromatography-mass spectrometry and 2D 1H-13C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell functi
Externí odkaz:
https://doaj.org/article/2e924f2360b54e9dbc6f6da13e566a04
Autor:
Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselée, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Visualizing endogenous GPCRs is challenging. Here the authors generate mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, design fluorescent dyes for specific labelling in complex tissue, and reve
Externí odkaz:
https://doaj.org/article/a1c114f010cf4dc7bafcaf994b474beb
Autor:
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112529- (2023)
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide
Externí odkaz:
https://doaj.org/article/557572b83b5a4a7ca84c9f23c0810f39
Autor:
Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.
Externí odkaz:
https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c
Autor:
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 r
Externí odkaz:
https://doaj.org/article/1bec881e08194ff3b4ad84658e067529
Autor:
Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M. Johnson, Alpesh Thakker, Rula Bany Bakar, Rebecca L. Westbrook, Jonathan P. Barlow, Monica Hoang, Jamie W. Joseph, Gareth G. Lavery, Ildem Akerman, James Cantley, Leanne Hodson, Daniel A. Tennant, David J. Hodson
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The α-ketoglutarate–dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is an HIF target that uses molecular oxygen to hydroxylate peptidyl prolyl residues. Although PHD3 has been reported to influence cancer cell metabolism and liver insulin se
Externí odkaz:
https://doaj.org/article/1bf081e6aea049debb7985fde804b9c9
Autor:
Laleh Pezhman, Sophie J Hopkin, Jenefa Begum, Silke Heising, Daniela Nasteska, Mussarat Wahid, G Ed Rainger, David J Hodson, Asif J Iqbal, Myriam Chimen, Helen M McGettrick
Publikováno v:
Clinical and Experimental Immunology. 212:1-10
Dysregulation of leukocyte trafficking, lipid metabolism, and other metabolic processes are the hallmarks that underpin and drive pathology in obesity. Current clinical management targets alternations in lifestyle choices (e.g. exercise, weight loss)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8b4a61c14481e7bff41cce35504a5e1
https://doi.org/10.1093/cei/uxad022
https://doi.org/10.1093/cei/uxad022
Autor:
Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Peter Hecht, Brian Rady, Ivona Bakaj, Alessandro Pocai, Lisa Norquay, Bernard Thorens, Mickaël Canouil, Philippe Froguel, Decio L. Eizirik, Miriam Cnop, Piero Marchetti
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108466- (2020)
Summary: Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate the molecular pathways underlying persistent or transient
Externí odkaz:
https://doaj.org/article/28763563ad6f4edd9dcabcb486fa39a2
Autor:
Katrina Viloria, Daniela Nasteska, Linford J.B. Briant, Silke Heising, Dean P. Larner, Nicholas H.F. Fine, Fiona B. Ashford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E. MacDonald, Ildem Akerman, Gareth G. Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, Martin Hewison, David J. Hodson
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107761- (2020)
Summary: Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although DBP serum levels,
Externí odkaz:
https://doaj.org/article/4961e1cbcd0b42b7a385bb7cadbfb0b4
Autor:
Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson
Publikováno v:
ACS Central Science, Vol 4, Iss 2, Pp 166-179 (2018)
Externí odkaz:
https://doaj.org/article/f8c0f33ccd2442baa687d32ec11cefda