Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Daniela, Fietz"'
Autor:
Birgit Stallmeyer, Clara Bühlmann, Rytis Stakaitis, Ann-Kristin Dicke, Farah Ghieh, Luisa Meier, Ansgar Zoch, David MacKenzie MacLeod, Johanna Steingröver, Özlem Okutman, Daniela Fietz, Adrian Pilatz, Antoni Riera-Escamilla, Miguel J. Xavier, Christian Ruckert, Sara Di Persio, Nina Neuhaus, Ali Sami Gurbuz, Ahmet Şalvarci, Nicolas Le May, Kevin McEleny, Corinna Friedrich, Godfried van der Heijden, Margot J. Wyrwoll, Sabine Kliesch, Joris A. Veltman, Csilla Krausz, Stéphane Viville, Donald F. Conrad, Dónal O’Carroll, Frank Tüttelmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract piRNAs are crucial for transposon silencing, germ cell maturation, and fertility in male mice. Here, we report on the genetic landscape of piRNA dysfunction in humans and present 39 infertile men carrying biallelic variants in 14 different p
Externí odkaz:
https://doaj.org/article/f298226160c54693a03e5498d577cfea
Autor:
Monika Raab, Izabela Kostova, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Seyed Mohsen Aberoumandi, Evelyn Ullrich, Sven Becker, Mourad Sanhaji, Klaus Strebhardt
Publikováno v:
Cancer Communications, Vol 44, Iss 1, Pp 101-126 (2024)
Abstract Background The cellular tumor protein p53 (TP53) is a tumor suppressor gene that is frequently mutated in human cancers. Among various cancer types, the very aggressive high‐grade serous ovarian carcinoma (HGSOC) exhibits the highest preva
Externí odkaz:
https://doaj.org/article/cdcbdaaef4af4c5cad1851cbfb3a4e85
Autor:
Daniela Fietz, Raouda Sgaier, Liza O’Donnell, Peter G. Stanton, Laura F. Dagley, Andrew I. Webb, Hans-Christian Schuppe, Thorsten Diemer, Adrian Pilatz
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionAzoospermia, characterized by an absence of sperm in the ejaculate, represents the most severe form of male infertility. While surgical sperm retrieval in obstructive azoospermia (OA) is successful in the majority of cases, patients with
Externí odkaz:
https://doaj.org/article/05dd56e6fba143f3ae70adeae3afa88a
Autor:
Ann-Kristin Dicke, Adrian Pilatz, Margot J. Wyrwoll, Margus Punab, Christian Ruckert, Liina Nagirnaja, Kenneth I. Aston, Donald F. Conrad, Sara Di Persio, Nina Neuhaus, Daniela Fietz, Maris Laan, Birgit Stallmeyer, Frank Tüttelmann
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-7 (2023)
Analysing genetic data from 1,655 men with non-obstructive azoospermia (NOA) reveals four independent loss-of-function variants in DDX3Y, suggesting that it is a key gene in the AZFa region and should be considered in diagnostic workflows for NOA.
Externí odkaz:
https://doaj.org/article/b6fc71cd78ac4af686a3f5be73425dc6
Autor:
Birte Schulz, Valérie Schumacher, Anaclet Ngezahayo, Daniela Maier-Begandt, Nadine Schadzek, Jochen Wilhelm, Wolfgang Weidner, Adrian Pilatz, Daniela Fietz, Sabine Kliesch, Nadine Schnepel, Nina Hambruch, Kristina Rode, Marion Langeheine, Ralph Brehm
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-20 (2023)
Abstract Background Germ cell tumors are relatively common in young men. They derive from a non-invasive precursor, called germ cell neoplasia in situ, but the exact pathogenesis is still unknown. Thus, further understanding provides the basis for di
Externí odkaz:
https://doaj.org/article/6c4470e7b8994476bce0642698dd6894
Autor:
Liza O’Donnell, Laura F. Dagley, Michael Curley, Annalucia Darbey, Peter J. O’Shaughnessy, Thorsten Diemer, Adrian Pilatz, Daniela Fietz, Peter G. Stanton, Lee B. Smith, Diane Rebourcet
Publikováno v:
PLoS ONE, Vol 18, Iss 9 (2023)
Sertoli cells support the development of sperm and the function of various somatic cells in the interstitium between the tubules. Sertoli cells regulate the function of the testicular vasculature and the development and function of the Leydig cells t
Externí odkaz:
https://doaj.org/article/b12856a5a9754a999cd00b7cc1ae9dd5
Autor:
Daniela Fietz, Adrian Pilatz, Thorsten Diemer, Florian Wagenlehner, Martin Bergmann, Hans-Christian Schuppe
Publikováno v:
Basic and Clinical Andrology, Vol 30, Iss 1, Pp 1-11 (2020)
Résumé Contexte Chez les hommes infertiles qui présentent une azoospermie non obstructive (NOA), le citrate de clomifène a été proposé comme pré-traitement avant la chirurgie pour extraction testiculaire de spermatozoïdes (TESE), surtout qua
Externí odkaz:
https://doaj.org/article/a589bbaae21f4ccc9c4e1609dbcfb3e6
Autor:
Lucia A. Torres-Fernández, Jana Emich, Yasmine Port, Sibylle Mitschka, Marius Wöste, Simon Schneider, Daniela Fietz, Manon S. Oud, Sara Di Persio, Nina Neuhaus, Sabine Kliesch, Michael Hölzel, Hubert Schorle, Corinna Friedrich, Frank Tüttelmann, Waldemar Kolanus
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mutations affecting the germline can result in infertility or the generation of germ cell tumors (GCT), highlighting the need to identify and characterize the genes controlling germ cell development. The RNA-binding protein and E3 ubiquitin ligase TR
Externí odkaz:
https://doaj.org/article/bbb96f35293748e18f3b5a151fccdc44
Autor:
Ann-Kristin Dicke, Jakob Albrethsen, Bradley L Hoare, Margot J Wyrwoll, Alexander S Busch, Daniela Fietz, Adrian Pilatz, Clara Bühlmann, Anders Juul, Sabine Kliesch, Jörg Gromoll, Ross A D Bathgate, Frank Tüttelmann, Birgit Stallmeyer
Publikováno v:
Human Reproduction.
STUDY QUESTION What is the impact of variants in the genes INSL3 (Insulin Like 3) and RXFP2 (Relaxin Family Peptide Receptor 2), respectively, on cryptorchidism and male infertility? SUMMARY ANSWER Bi-allelic loss-of-function (LoF) variants in INSL3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca1e1aff5a176df99f4858f88e2dbb8c
https://doi.org/10.1093/humrep/dead105
https://doi.org/10.1093/humrep/dead105
Publikováno v:
Cells, Vol 10, Iss 5, p 1176 (2021)
Polo-like kinases (PLKs) belong to a five-membered family of highly conserved serine/threonine kinases (PLK1-5) that play differentiated and essential roles as key mitotic kinases and cell cycle regulators and with this in proliferation and cellular
Externí odkaz:
https://doaj.org/article/8771222b5f17450782b0fcef69432fc7