Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Daniel Zewge"'
Autor:
Christopher K. Prier, Karla Camacho Soto, Jacob H. Forstater, Nadine Kuhl, Jeffrey T. Kuethe, Wai Ling Cheung-Lee, Michael J. Di Maso, Claire M. Eberle, Shane T. Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin M. Maloney, Amanda Makarewicz, Jonathan P. McMullen, Jeffrey C. Moore, Grant S. Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David A. Thaisrivongs, Deeptak Verma, Adeya Wyatt, Daniel Zewge
Publikováno v:
ACS Catalysis. :7707-7714
Enzymes are capable of unique and selective transformations that can enable sustainable chemical production. While many industrial processes have been developed using free enzymes in aqueous solutions, immobilizing enzymes on a solid support can offe
Autor:
Nadine Kuhl, Ben W. H. Turnbull, Yining Ji, Reed T. Larson, Michael Shevlin, Christopher K. Prier, Cheol K. Chung, Richard Desmond, Erik Guetschow, Cyndi Qixin He, Tetsuji Itoh, Jeffrey T. Kuethe, Justin A. Newman, Mikhail Reibarkh, Nelo R. Rivera, Gao Shang, Zhixun Wang, Daniel Zewge, David A. Thaisrivongs
Publikováno v:
Green Chemistry. 25:606-613
The development of a protecting group-free, 2-step synthesis of 5-amino-2-hydroxymethyltetrahydropyran 1a from biorenewable Cyrene™ is described which renders access to BTK-inhibitor nemtabrutinib (2) more efficient and sustainable.
Publikováno v:
Organic Process Research & Development. 23:2758-2763
A low-cost compact mass spectrometer was effectively utilized for identifying and tracking process impurities in the early stage development of a multistep synthetic protocol used to prepare the verubecestat drug substance. Process optimizations were
Publikováno v:
Organic Process Research & Development. 23:1674-1678
Verubecestat is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor which was previously evaluated for the treatment of Alzheimer’s disease. The synthesis of verubecestat relies ...
Autor:
Daniel Zewge, Xiaoyi Gong, Yizhou Liu, Zhu Liu, Brett Harman, Xiaodong Bu, Huaming Sheng, Mikhail Reibarkh
Publikováno v:
Reaction Chemistry & Engineering. 3:146-150
A hemiaminal derivative identified during preparation of the penultimate of ceftolozane 1, mandated a thorough investigation of the source of the impurity. N,N-Dimethylacetamide (DMAc) subjected to oxidation was found to be the culprit generating oxi
Autor:
Laura Sepp-Lorenzino, Hangchun Zhang, Yi Pei, South Victoria J, Steven L. Colletti, Wonsuk Chang, Daniel Zewge, Matthew G. Stanton, Jillian DiMuzio, Edward C. Sherer, Craig A. Parish, Erin N. Guidry, Walter Strapps
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4513-4517
Single-stranded silencing RNAs (ss siRNA), while not as potent as duplex RNAs, have the potential to become a novel platform technology in RNA interference based gene silencing by virtue of their simplicity and plausibly favorable characteristics in
Autor:
Edward C. Sherer, Zhen Li, Daniel Zewge, Gabor Butora, Ian W. Davies, Joseph D. Armstrong, Greg Copeland, David M. Tellers, Joseph R. Gouker, Daniel R. Sidler, Vasant Jadhav
Publikováno v:
Bioconjugate chemistry. 29(6)
An efficient multicomponent orthogonal protocol was developed for post-synthetic oligonucleotide modification using commercially available 2'- O-methyl ester and 2'- O-propargyl nucleoside scaffolds. Amidation of methyl esters with primary amines was
Autor:
Gabriel C. Graffius, Daniel Zewge, Holst M. Halsey, Robert Hartman, Brandon M. Jocher, Xiaodong Bu, Erik L. Regalado, Gary Lee, Frank Bernardoni
Publikováno v:
Journal of chromatography. A. 1518
Volatile amines are among the most frequently used chemicals in organic and pharmaceutical chemistry. Synthetic route optimization often involves the evaluation of several different amines requiring the development and validation of analytical method
Autor:
Andrew Nolting, Daniel Zewge, Jacob M. Janey, Zhiguo J. Song, David M. Tellers, Paul N. Devine, Steven F. Oliver, David M. Tschaen, Dietrich Steinhuebel, Peter G. Dormer
Publikováno v:
Organic Process Research & Development. 18:423-430
A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.
Autor:
Ian W. Davies, Paul N. Devine, Robert A. Reamer, David M. Tschaen, Fei Zhang, Daniel Zewge, Jeffrey T. Kuethe, David R. Lieberman, Zhihui Peng, Kevin M. Belyk, David M. Tellers, Guy R. Humphrey, Peter G. Dormer, Michel Journet, Andrew Nolting, Marjorie S. Waters, Dalian Zhao, Zhiguo J. Song
Publikováno v:
The Journal of Organic Chemistry. 76:7804-7815
Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macrolactamizatio