Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Daniel Zenklusen"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102359- (2023)
Summary: Two isoforms of the nuclear pore complex (NPC) have been identified in the yeast S. cerevisiae, which coexist at the periphery of the nucleus and differ by the presence or absence of a nuclear basket. Here, we present a protocol to isolate t
Externí odkaz:
https://doaj.org/article/efcaec0098ee4d748f13b1fe59c5a6e8
Publikováno v:
Molecular cell. 82(20)
To determine which transcripts should reach the cytoplasm for translation, eukaryotic cells have established mechanisms to regulate selective mRNA export through the nuclear pore complex (NPC). The nuclear basket, a substructure of the NPC protruding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c738a4d39d5307ddb7304e4ef2566b
https://pubmed.ncbi.nlm.nih.gov/36220102
https://pubmed.ncbi.nlm.nih.gov/36220102
To determine which transcripts should reach the cytoplasm for translation, eukaryotic cells have established mechanisms to regulate selective mRNA export through the nuclear pore complex (NPC). The nuclear basket, a substructure of the NPC protruding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac90ec3012f07f8f77972161d7d674f3
https://doi.org/10.1101/2021.11.07.467636
https://doi.org/10.1101/2021.11.07.467636
SummaryIntron removal from pre-mRNAs is a critical step in the processing of RNA polymerase II transcripts, required to create translation competent mRNAs. In humans, introns account for large portions of the pre-mRNA, with intronic sequences represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9536e0b862f97051005ebb14ef62e88
https://doi.org/10.1101/2021.10.27.466141
https://doi.org/10.1101/2021.10.27.466141
Publikováno v:
Wiley interdisciplinary reviews. RNAREFERENCES. 12(6)
The nuclear pore complex (NPC) serves as a central gate for mRNAs to transit from the nucleus to the cytoplasm. The ability for mRNAs to get exported is linked to various upstream nuclear processes including co-transcriptional RNP assembly and proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599eb9c387830a7fce1c3099f7c2bcbd
https://pubmed.ncbi.nlm.nih.gov/33938148
https://pubmed.ncbi.nlm.nih.gov/33938148
Autor:
Daniel Zenklusen, Rachy Abraham, Aakash Koppula, Anthony K.L. Leung, Diane E. Griffin, Srivathsan Adivarahan, Aravinth Kumar Jayabalan, Mona Batish
Publikováno v:
Proc Natl Acad Sci U S A
While biomolecular condensates have emerged as an important biological phenomenon, mechanisms regulating their composition and the ways that viruses hijack these mechanisms remain unclear. The mosquito-borne alphaviruses cause a range of diseases fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0228fda476a30489f54b8a7c499ff002
https://doi.org/10.1073/pnas.2021719118
https://doi.org/10.1073/pnas.2021719118
Publikováno v:
Methods in Molecular Biology ISBN: 9781071609347
mRNAs and lncRNAs assemble with RNA-binding proteins (RBPs) to form ribonucleoprotein complexes (RNPs ). The assembly of RNPs initiates co-transcriptionally, and their composition and organization is thought to change during the different steps of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ff62217c4307040f08ff79ce379e3a2
https://doi.org/10.1007/978-1-0716-0935-4_17
https://doi.org/10.1007/978-1-0716-0935-4_17
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2209
mRNAs and lncRNAs assemble with RNA-binding proteins (RBPs) to form ribonucleoprotein complexes (RNPs ). The assembly of RNPs initiates co-transcriptionally, and their composition and organization is thought to change during the different steps of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1592a49e126fb2169640b2f9bb99eb9b
https://pubmed.ncbi.nlm.nih.gov/33201475
https://pubmed.ncbi.nlm.nih.gov/33201475
Autor:
Xavier Deschênes-Simard, Marlene Oeffinger, Cornelia E. Zorca, Sebastian Igelmann, Léa Brakier-Gingras, Daniel Zenklusen, Emmanuelle Saint-Germain, Olga Moiseeva, Geneviève Huot, Neylen Del Toro, Lian Mignacca, Benjamin Le Calvé, Marinieve Montero, Marie-Camille Rowell, Frédéric Lessard, Véronique Bourdeau, Gerardo Ferbeyre, Christian Trahan, Marina Bury, Stéphane Lopes-Paciencia
Publikováno v:
Nature Cell Biology. 20:789-799
Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73568848198ad7a458ebe043b524f17e
https://doi.org/10.1038/s41556-018-0127-y
https://doi.org/10.1038/s41556-018-0127-y
Autor:
Emily A. Bruce, Philip Eisenhauer, Jason Botten, Christopher M. Ziegler, Benjamin R. King, Daniel Zenklusen, Samuel Kellner
Publikováno v:
The Journal of General Virology
We report a fluorescence in situ hybridization (FISH) assay that allows the visualization of lymphocytic choriomeningitis mammarenavirus (LCMV) genomic RNAs in individual cells. We show that viral S segment genomic and antigenomic RNA, along with vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d91232ac494b1393ec0bbdbd3f6b65
https://doi.org/10.1099/jgv.0.000930
https://doi.org/10.1099/jgv.0.000930