Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Daniel Yuen"'
Autor:
Serena L. Y. Teo, Joshua J. Rennick, Daniel Yuen, Hareth Al-Wassiti, Angus P. R. Johnston, Colin W. Pouton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Our understanding of cytosolic delivery is hindered by existing methods for quantification which suffer from being indirect and showing low sensitivity. Here the authors report a SLEEQ (Split Luciferase Endosomal Escape Quantification) assay to asses
Externí odkaz:
https://doaj.org/article/51c2a8863f7b4866907c4bcbaa87460c
Autor:
Laura I. FitzGerald, Luigi Aurelio, Moore Chen, Daniel Yuen, Joshua J. Rennick, Bim Graham, Angus P. R. Johnston
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Determining the trafficking of intracellular material is commonly done by colocalisation analysis using microscopy. Here the authors monitor trafficking of select cargo by measuring the conversion of quenched SNAP-tag substrates by subcellularly-loca
Externí odkaz:
https://doaj.org/article/67585245818b4c449e5738f29dc6b93c
Autor:
Daniel Yuen-Teh Liu, 柳源德
96
In Escherichia coli, the biosynthesis of lysine is generated from aspartate, and the process contains nine steps. Aspartokinase III encoded by lysC, catalyzes the first step of lysine biosynthesis. In this thesis, we generated a lysC knockout
In Escherichia coli, the biosynthesis of lysine is generated from aspartate, and the process contains nine steps. Aspartokinase III encoded by lysC, catalyzes the first step of lysine biosynthesis. In this thesis, we generated a lysC knockout
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/77551999178124478092
Autor:
Daniel Yuen-Teh Liu, 柳源德
87
Patients suffer by cancer, sepsis or trauma usually also suffer by muscle wasting. Present studies showed that muscle wasting may cause by cytokines such as tumor necrosis factor-alpha and interleukin-1 released from activated immune system.
Patients suffer by cancer, sepsis or trauma usually also suffer by muscle wasting. Present studies showed that muscle wasting may cause by cytokines such as tumor necrosis factor-alpha and interleukin-1 released from activated immune system.
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/65216863989396752194
Autor:
Orlagh M. Feeney, Katie Ardipradja, Ka Fung Noi, Dharmini Mehta, Robert De Rose, Daniel Yuen, Angus P.R. Johnston, Lee Kingston, Cecilia Ericsson, Charles S. Elmore, Richard Hufton, David J. Owen, Marianne B. Ashford, Christopher J.H. Porter
Publikováno v:
Journal of Controlled Release. 348:420-430
As a malignant tumour of lymphatic origin, B-cell lymphoma represents a significant challenge for drug delivery, where effective therapies must access malignant cells in the blood, organs and lymphatics while avoiding off-target toxicity. Subcutaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd87b77b5dc91c4fdffa5fa891547b3a
https://doi.org/10.1016/j.jconrel.2022.05.041
https://doi.org/10.1016/j.jconrel.2022.05.041
Autor:
Angus P. R. Johnston, Daniel Yuen, Colin W. Pouton, Joshua J. Rennick, Serena L. Y. Teo, Hareth Al-Wassiti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Cytosolic transport is an essential requirement but a major obstacle to efficient delivery of therapeutic peptides, proteins and nucleic acids. Current understanding of cytosolic delivery mechanisms remains limited due to a significant number of conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f263d11cd91c4aebd61b6879f36df27
https://doaj.org/article/51c2a8863f7b4866907c4bcbaa87460c
https://doaj.org/article/51c2a8863f7b4866907c4bcbaa87460c
Autor:
Adelene S M, Wong, Ewa, Czuba, Moore Z, Chen, Daniel, Yuen, Kristofer I, Cupic, Shenglin, Yang, Rebecca Y, Hodgetts, Laura I, Selby, Angus P R, Johnston, Georgina K, Such
Publikováno v:
ACS macro letters. 6(3)
Targeting nanoparticles to specific cellular receptors has the potential to deliver therapeutic compounds to target sites while minimizing side effects. To this end, we have conjugated a targeting protein, holo-transferrin (holo-Tf), to pH-responsive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c1cb2d3770f100fead5f09a109d7a73
https://pubmed.ncbi.nlm.nih.gov/35650909
https://pubmed.ncbi.nlm.nih.gov/35650909
Publikováno v:
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyREFERENCES. 14(6)
Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and therefore have significant potential to treat genetic disorders, infectious diseases, and cancer. However, while clinically approved to treat a small number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e5cc121abddd4af4328c1848eb8af9
https://pubmed.ncbi.nlm.nih.gov/36416028
https://pubmed.ncbi.nlm.nih.gov/36416028
Publikováno v:
Nature Nanotechnology. 16:37-46
Induced tolerogenic dendritic cells are a powerful immunotherapy for autoimmune disease that have shown promise in laboratory models of disease and early clinical trials. In contrast to conventional immunosuppressive treatments, tolerogenic immunothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8745b32a3bcdc7bb265a4556538a7a5
https://doi.org/10.1038/s41565-020-00810-2
https://doi.org/10.1038/s41565-020-00810-2
Publikováno v:
ACS Applied Materials & Interfaces. 12:5593-5600
Nanoparticles targeted to specific cells have the potential to improve the delivery of therapeutics. The effectiveness of cell targeting can be significantly improved by optimizing how the targeting ligands are displayed on the nanoparticle surface.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6d2a3eaac291ffc5a044b88da223c7
https://doi.org/10.1021/acsami.9b20993
https://doi.org/10.1021/acsami.9b20993