Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Daniel Ysselstein"'
Autor:
Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik, Jean-Christophe Rochet
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Abstract Background α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics th
Externí odkaz:
https://doaj.org/article/577ae13724214a3bac084228b03fe4b4
Autor:
Daniel Ysselstein, Maria Nguyen, Tiffany J. Young, Alex Severino, Michael Schwake, Kalpana Merchant, Dimitri Krainc
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Mutations in LRRK2 and GBA1, which encodes glucocerebrosidase (GCase), are associated with Parkinson’s disease. Here the authors show that LRRK2 is a negative regulator of lysosomal GCase activity, using dopaminergic neurons derived from iPSCs from
Externí odkaz:
https://doaj.org/article/dce1b24fa3264d3787c4092c8b341351
Autor:
Karen S. Conrad, Ting-Wen Cheng, Daniel Ysselstein, Saskia Heybrock, Lise R. Hoth, Boris A. Chrunyk, Christopher W. am Ende, Dimitri Krainc, Michael Schwake, Paul Saftig, Shenping Liu, Xiayang Qiu, Michael D. Ehlers
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP
Externí odkaz:
https://doaj.org/article/89053b7dbfca4e9d97832de177661289
Autor:
Jörn M. Völker, Mykola Dergai, Luciano A. Abriata, Yves Mingard, Daniel Ysselstein, Dimitri Krainc, Matteo Dal Peraro, Gabriele Fischer von Mollard, Dirk Fasshauer, Judith Koliwer, Michael Schwake
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1391-1398 (2017)
Progressive myoclonus epilepsies (PMEs) are inherited disorders characterized by myoclonus, generalized tonic-clonic seizures, and ataxia. One of the genes that is associated with PME is the ER-to-Golgi Qb-SNARE GOSR2, which forms a SNARE complex wit
Externí odkaz:
https://doaj.org/article/7144d805276745b29e2b76a780c76495
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211727 (2019)
The life cycle of cultured proliferating cells is characterized by fluctuations in cell population density induced by periodic subculturing. This leads to corresponding changes in micro- and macroenvironment of the cells, accompanied by altered cellu
Externí odkaz:
https://doaj.org/article/47b17196949541b4b238a3758277652d
Autor:
Daniel Ysselstein, Mehul Joshi, Vartika Mishra, Amy M. Griggs, Josephat M. Asiago, George P. McCabe, Lia A. Stanciu, Carol Beth Post, Jean-Christophe Rochet
Publikováno v:
Neurobiology of Disease, Vol 79, Iss , Pp 150-163 (2015)
The post-mortem brains of individuals with Parkinson's disease (PD) and other synucleinopathy disorders are characterized by the presence of aggregated forms of the presynaptic protein α-synuclein (aSyn). Understanding the molecular mechanism of aSy
Externí odkaz:
https://doaj.org/article/99bd0c3cd7124b7b823323d5ca817691
Autor:
Shalini Padmanabhan, Warren D. Hirst, Maria Nguyen, Tiffany J. Young, Nicolas Dzamko, Daniel Ysselstein, Dimitri Krainc
Publikováno v:
Movement Disorders. 36:2719-2730
Mutations in GBA1, which encode for the protein glucocerebrosidase (GCase), are the most common genetic risk factor for Parkinson's disease and dementia with Lewy bodies. In addition, growing evidence now suggests that the loss of GCase activity is a
Autor:
Tiffany J. Young, Maria Nguyen, Alex Severino, Daniel Ysselstein, Dimitri Krainc, Michael Schwake, Kalpana Merchant
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
Mutations in LRRK2 and GBA1 are common genetic risk factors for Parkinson’s disease (PD) and major efforts are underway to develop new therapeutics that target LRRK2 or glucocerebrosidase (GCase). Here we describe a mechanistic and therapeutic conv
Autor:
Daniel Ysselstein, Antonius Koller, Ranjan Sengupta, Jason R. Cannon, Aswathy Chandran, Seema Mattoo, Ali Camara, Anwesha Sanyal, Sayan Dutta, Paola Catherine Montenegro, Jean-Christophe Rochet, Ben G. Watson
Publikováno v:
J Mol Biol
During disease, cells experience various stresses that manifest as an accumulation of misfolded proteins and eventually lead to cell death. To combat this stress, cells activate a pathway called unfolded protein response that functions to maintain en
Publikováno v:
Mov Disord
Lysosomal storage disorders comprise a clinically heterogeneous group of autosomal-recessive or X-linked genetic syndromes caused by disruption of lysosomal biogenesis or function resulting in accumulation of nondegraded substrates. Although lysosoma