Proteomic profiling of a patient with cutaneous melanoma metastasis regression following topical contact sensitizer diphencyprone and immune checkpoint inhibitor treatment

Autor: Joseph Han, Aneesh Agarwal, Jade N. Young, Shayan Owji, Yen Luu, Dina Poplausky, Daniel Yassky, Yeriel Estrada, Jonathan Ungar, James G. Krueger, Nicholas Gulati

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)

Abstract Immune checkpoint inhibitors (ICIs) such as pembrolizumab have revolutionized the treatment of advanced melanoma, but many patients do not respond to ICIs alone, and thus there is need for additional treatment options. Topical immunomodulato

Externí odkaz: https://doaj.org/article/d6e67a2fe1c6416fb2a6433de815f5be

Modulation of Inflammatory Proteins in Serum May Reflect Cutaneous Immune Responses in Cancer Immunotherapy

Autor: Joseph Han, Joel Correa da Rosa, Aneesh Agarwal, Shayan Owji, Daniel Yassky, Yen Luu, Aatman Shah, Yeriel Estrada, Jonathan Ungar, Kavita Y. Sarin, James G. Krueger, Nicholas Gulati

Publikováno v: JID Innovations, Vol 3, Iss 2, Pp 100179- (2023)

Diphencyprone (DPCP), a topical contact sensitizer, has shown efficacy in treating cutaneous melanoma metastases, including at times beyond the directly treated sites, but biomarkers indicative of treatment response have not been characterized. Thus,

Externí odkaz: https://doaj.org/article/cedabaa3ff184ea18d627d5882d60109

A worthwhile tool in evaluating worrisome lesions.

Autor: Owji S; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Aguwa C; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Han J; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Yassky D; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Luu Y; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Glausser M; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Gulati N; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Ungar B; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Napolitano D; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano)., Ungar J; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY (Drs. Owji, Han, Gulati, B. Ungar, and J. Ungar and Daniel Yassky); Meharry Medical College, Nashville, TN (Chibuzo Aguwa); University of Missouri-Kansas City School of Medicine (Dr. Luu); The Institute for Family Health, New York, NY (Dr. Glausser); Community Healthcare Network, New York, NY (Dr. Napolitano).

Publikováno v: The Journal of family practice [J Fam Pract] 2023 Sep; Vol. 72 (7), pp. E1-E22.