Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Daniel Y. Hung"'
Autor:
Daniel Y. Hung, Herman W. Barkema, Ronald Chan, Paul L. Beck, Ji Li, Aito Ueno, Miriam Fort Gasia, Marietta Iacucci, Shem Chenoo, Michael R. Tom, Humberto Jijon, Gilaad G. Kaplan, Vijay Yajnik, Subrata Ghosh, Remo Panaccione, Andre G. Buret
Publikováno v:
Inflammatory bowel diseases. 22(7)
BACKGROUND Distinct CD8+ T-cell subsets such as interleukin-17-expressing Tc17 and Foxp3-expressing Tcreg are functionally similar to CD4+ T cells. Though CD4+ T cells are dysregulated in patients with inflammatory bowel disease (IBD), CD8+ T cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45c3d61b88adb5b91ae3180a77d3983
https://pubmed.ncbi.nlm.nih.gov/27306067
https://pubmed.ncbi.nlm.nih.gov/27306067
Publikováno v:
Hunt, C Anthony; Ropella, Glen E P; Yan, Li; Hung, Daniel Y; & Roberts, Michael S. (2006). Physiologically based synthetic models of hepatic disposition. Journal of Pharmacokinetics and Pharmacodynamics, 33(6), 737-772. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5r29n0mk
Current Physiologically based pharmacokinetic (PBPK) models are inductive. We present an additional, different approach that is based on the synthetic rather than the inductive approach to modeling and simulation. It relies on object-oriented program
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24337c77674368a343954b0d953dc50
https://doi.org/10.1007/s10928-006-9031-3
https://doi.org/10.1007/s10928-006-9031-3
Publikováno v:
British Journal of Pharmacology. 145:57-65
1 The disposition kinetics of [H-3] taurocholate ([H-3]TC) in perfused normal and cholestatic rat livers were studied using the multiple indicator dilution technique and several physiologically based pharmacokinetic models. 2 The serum biochemistry l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c88d34aa89039fe26b9dca2974a8a6
https://doi.org/10.1038/sj.bjp.0706148
https://doi.org/10.1038/sj.bjp.0706148
Autor:
Daniel Y. Hung, Frank J. Burczynski, Ping Chang, Michael S. Roberts, Andrew L. Lewis, Gopalan Rajaraman, Guqi Wang, Bassam M. Elmadhoun
Publikováno v:
Molecular and Cellular Biochemistry. 270:115-124
Understanding the driving forces for the hepatic uptake of endogenous and exogenous substrates in isolated cells and organs is fundamental to describing the underlying hepatic physiology/pharmacology. In this study we investigated whether uptake of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de623147fbaa79e617dd59952040a7a2
https://doi.org/10.1007/s11010-005-5267-2
https://doi.org/10.1007/s11010-005-5267-2
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 288:G93-G100
Nonalcoholic fatty liver disease is the most common of all liver diseases. The hepatic disposition [3H]palmitate and its low-molecular-weight metabolites in perfused normal and steatotic rat liver were studied using the multiple indicator dilution te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6da7d0c34de9f430bdd108da903814
https://doi.org/10.1152/ajpgi.00196.2004
https://doi.org/10.1152/ajpgi.00196.2004
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 311:822-829
The aim of this study was to define the determinants of the linear hepatic disposition kinetics of propranolol optical isomers using a perfused rat liver. Monensin was used to abolish the lysosomal proton gradient to allow an estimation of propranolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f310f8630fba372695e0c5e01662c00e
https://doi.org/10.1124/jpet.104.070011
https://doi.org/10.1124/jpet.104.070011
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:228-235
This study investigated the relative contribution of ion-trapping, microsomal binding, and distribution of unbound drug as determinants in the hepatic retention of basic drugs in the isolated perfused rat liver. The ionophore monensin was used to abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b14fd17cdb66e4d8e5b5b0477da5738
https://doi.org/10.1124/jpet.103.056770
https://doi.org/10.1124/jpet.103.056770
Autor:
Gerhard A. Siebert, Frank J. Burczynski, Daniel Y. Hung, Paul P. Masci, Ping Chang, Andrew L. Lewis, Michael S. Roberts, Yuri German Anissimov
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 284:G423-G433
Disposition kinetics of [3H]palmitate and its low-molecular-weight metabolites in perfused rat livers were studied using the multiple-indicator dilution technique, a selective assay for [3H]palmitate and its low-molecular-weight metabolites, and seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a8d44f200a4703e333840c3a58f83e
https://doi.org/10.1152/ajpgi.00328.2002
https://doi.org/10.1152/ajpgi.00328.2002
Publikováno v:
Hepatology. 36:1180-1189
Four animal models were used to quantitatively evaluate hepatic alterations in this study: (1) a carbon tetrachloride control group (phenobarbital treatment only), (2) a CCl(4)-treated group (phenobarbital with CCl(4) treatment), (3) an alcohol-treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca881744b6b3b2ab5ca942cfb234acfa
https://doi.org/10.1053/jhep.2002.36820
https://doi.org/10.1053/jhep.2002.36820
Publikováno v:
British Journal of Pharmacology. 130:1331-1338
1 The binding kinetics of diclofenac to hepatocellular structures were evaluated in the perfused rat liver using the multiple indicator dilution technique and a stochastic model of organ transit time density. 2 The single-pass, in situ rat liver prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c76284dbe0fafe675b6b7c258bdea2f
https://doi.org/10.1038/sj.bjp.0703448
https://doi.org/10.1038/sj.bjp.0703448