Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Daniel Weissberger"'
Publikováno v:
Molecules, Vol 29, Iss 20, p 4949 (2024)
Covalent drugs can offer significant advantages over non-covalent drugs in terms of pharmacodynamics (i.e., target-binding properties). However, the development of covalent drugs is sometimes hampered by pharmacokinetic limitations (e.g., low bioavai
Externí odkaz:
https://doaj.org/article/805cc9c8b4584002a97f9e54619e76a4
Autor:
Nicole L. Richardson, Renate Griffith, Nicole M. Jones, Christopher J. Schofield, Luke Hunter, Laura J. O'Malley, Anthony Tumber, Daniel Weissberger
Publikováno v:
Bioorganicmedicinal chemistry. 38
Prolyl hydroxylase (PHD) enzymes play a critical role in the cellular responses to hypoxia through their regulation of the hypoxia inducible factor α (HIF-α) transcription factors. PHD inhibitors show promise for the treatment of diseases including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d9d0451d2cdbf81466bd45bf92e24c
https://pubmed.ncbi.nlm.nih.gov/33862469
https://pubmed.ncbi.nlm.nih.gov/33862469
Publikováno v:
Chemical Reviews. 120:9743
Cyclic peptides are promising scaffolds for drug development, attributable in part to their increased conformational order compared to linear peptides. However, when optimizing the target-binding or pharmacokinetic properties of cyclic peptides, it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5051ce7ad6f2fd50c03af47cb26c7a
https://doi.org/10.1021/acs.chemrev.0c00013
https://doi.org/10.1021/acs.chemrev.0c00013