Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Daniel Weekes"'
Autor:
Ilirjana Bajrami, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Andrew J. Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated tha
Externí odkaz:
https://doaj.org/article/d5f5e8c9681d4c1cb2934f06ed9a1386
Autor:
Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra, Andrew N. J. Tutt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions a
Externí odkaz:
https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca400
Autor:
Dalia Tarantino, Callum Walker, Daniel Weekes, Helen Pemberton, Kathryn Davidson, Gonzalo Torga, Jessica Frankum, Ana M. Mendes-Pereira, Cynthia Prince, Riccardo Ferro, Rachel Brough, Stephen J. Pettitt, Christopher J. Lord, Anita Grigoriadis, Andrew NJ Tutt
Publikováno v:
Oncogene. 41:3969-3977
HORMAD1 expression is usually restricted to germline cells, but it becomes mis-expressed in epithelial cells in ~60% of triple-negative breast cancers (TNBCs), where it is associated with elevated genomic instability (1). HORMAD1 expression in TNBC i
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Figure S1. Frequency of genomic aberrations in the KCL TNBC cohort. Supplementary Figure S2. Conceptual diagrams of Scores of Chromosomal Instability Scarring (SCINS). Supplementary Figure S3. Extent and location of SCINS in TNBC. Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094e1985f5e799065b529af5433df180
https://doi.org/10.1158/2159-8290.22531226.v1
https://doi.org/10.1158/2159-8290.22531226.v1
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Methods, Figure Legends, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f34678b3a6f52c27a52aa3119cc173
https://doi.org/10.1158/2159-8290.22531220
https://doi.org/10.1158/2159-8290.22531220
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Table S1. KCL TNBC and breast cell line cohort characteristics. Supplementary Table S2. Categories of genomic segment used as the basis for measuring SCINS. Supplementary Table S3. Genes expressed in a SAM of different SCINS clusters. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af647901e150db501520ef97984d3d5
https://doi.org/10.1158/2159-8290.22531217.v1
https://doi.org/10.1158/2159-8290.22531217.v1
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
SWEAVE document. R code for SCINS analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c56521fa34f9659ba0fc42cd02277f
https://doi.org/10.1158/2159-8290.22531223.v1
https://doi.org/10.1158/2159-8290.22531223.v1
Autor:
Nadia Abed Al-Hazmi, Turki Yousef Alhazzazi, Sahar Mohammed Nour Bukhary, Daniel Weekes, Fraser McDonald, Peter Hill, Agamemnon Grigoriadis, Raghad Abdullah Al-Dabbagh
Publikováno v:
Archives Of Pharmacy Practice. 12:125-133
Autor:
Andrew Tutt, Syed Haider, John Alexander, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Christopher J. Lord, Rachel Brough, Andrew J. Wicks, Stephen J. Pettitt, Ilirjana Bajrami
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
PARP enzymes utilise NAD+ as a co-substrate for their enzymatic activity. Inhibition of PARP1 is synthetic lethal with defects in either BRCA1 or BRCA2. In order to assess whether other genes implicated in NAD+ metabolism were synthetic lethal with B
Autor:
Kristijan Ramadan, Andrew J. Wicks, Yilun Sun, Andrew Tutt, Eleanor Knight, Christopher J. Lord, Mercedes Pardo Calvo, Dragomir B. Krastev, Jyoti S. Choudhary, Yves Pommier, Shudong Li, Tanaji T. Talele, Jiri Bartek, Lu Yu, Stephen J. Pettitt, Daniel Weekes, Luned M. Badder, Rebecca Marlow
Summary paragraphPoly-(ADP-ribose) polymerase inhibitors (PARPi) elicit anti-tumour activity in homologous recombination defective cancers by promoting cytotoxic, chromatin-bound, “trapped” PARP1. How cells process trapped PARP1 remains unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40976d3695cd0608b753e0e491a87e4a
https://doi.org/10.1101/2021.07.16.452473
https://doi.org/10.1101/2021.07.16.452473