Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Daniel Wambua"'
Autor:
Edward M. Kennedy, Agnieszka Denslow, Jacqueline Hewett, Lingxin Kong, Ana De Almeida, Jeffrey D. Bryant, Jennifer S. Lee, Judy Jacques, Sonia Feau, Melissa Hayes, Elizabeth L. McMichael, Daniel Wambua, Terry Farkaly, Amal A Rahmeh, Lauren Herschelman, Danielle Douglas, Jacob Spinale, Sanmit Adhikari, Jessica Deterling, Matt Scott, Brian B. Haines, Mitchell H. Finer, Ted T Ashburn, Christophe Quéva, Lorena Lerner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The development of neutralizing antibodies can limit the therapeutic effectiveness of systemically administered oncolytic viruses (OV). Here, to enable repeated intravenous administration, the authors report the development of synthetic RNA viruses f
Externí odkaz:
https://doaj.org/article/e35ea397d9ba41b5b30d0dfa85eb8713
Autor:
Edward M. Kennedy, Terry Farkaly, Peter Grzesik, Jennifer Lee, Agnieszka Denslow, Jacqueline Hewett, Jeffrey Bryant, Prajna Behara, Caitlin Goshert, Daniel Wambua, Ana De Almeida, Judith Jacques, Damian Deavall, James B. Rottman, Joseph C. Glorioso, Mitchell H. Finer, Brian B. Haines, Christophe Quéva, Lorena Lerner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 476-490 (2020)
Development of next-generation oncolytic viruses requires the design of vectors that are potently oncolytic, immunogenic in human tumors, and well tolerated in patients. Starting with a joint-region deleted herpes simplex virus 1 (HSV-1) to create la
Externí odkaz:
https://doaj.org/article/b74418f2850d47de82488eefe949e024
Autor:
Zachary B Davis, Andrew Cogswell, Hamish Scott, Amanda Mertsching, Julie Boucau, Daniel Wambua, Sylvie Le Gall, Vicente Planelles, Kerry S Campbell, Edward Barker
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005421 (2016)
Major histocompatibility class I (MHC-I)-specific inhibitory receptors on natural killer (NK) cells (iNKRs) tolerize mature NK cell responses toward normal cells. NK cells generate cytolytic responses to virus-infected or malignant target cells with
Externí odkaz:
https://doaj.org/article/6703e51e354e43bca09bb81e0b6f0822
Autor:
Christophe Quéva, Lorena Lerner, Edward M. Kennedy, Sonia Feau, Melissa W. Hayes, Mitchel H. Finer, Allison Colthart, Michael Ball, Caitlin Goshert, Judith Jacques, Prajna Behera, Lingxin Kong, Daniel Wambua, Jacqueline Hewett, Terry Farkaly, Jennifer S. Lee, Peter Grzesik, Agnieszka Denslow, Brian B. Haines
Supplemental Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfb51c9f36daf3b0ec0c09daa990df8
https://doi.org/10.1158/2326-6066.22543431.v1
https://doi.org/10.1158/2326-6066.22543431.v1
Autor:
Christophe Quéva, Lorena Lerner, Edward M. Kennedy, Sonia Feau, Melissa W. Hayes, Mitchel H. Finer, Allison Colthart, Michael Ball, Caitlin Goshert, Judith Jacques, Prajna Behera, Lingxin Kong, Daniel Wambua, Jacqueline Hewett, Terry Farkaly, Jennifer S. Lee, Peter Grzesik, Agnieszka Denslow, Brian B. Haines
ONCR-177 is an engineered recombinant oncolytic herpes simplex virus (HSV) with complementary safety mechanisms, including tissue-specific miRNA attenuation and mutant UL37 to inhibit replication, neuropathic activity, and latency in normal cells. ON
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a6663d25128f50d686dbfb13f50074
https://doi.org/10.1158/2326-6066.c.6550257.v1
https://doi.org/10.1158/2326-6066.c.6550257.v1
Autor:
null Moses Gakuru, George Karuoya Gitau, null Muthee John Kaunga, null Davis Ikiror, null Daniel Wambua Muasya
Publikováno v:
East African Journal of Science, Technology and Innovation. 4
In Kenya, helminthosis and coccidia infections in cattle, are the second highest cause of death in zebu calves up to 12 months old, estimated at 12% mortality rate. The aim of our study was to investigate the factors associated with helminth and cocc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b57ee84e829a4a4a9168169a06b75ad7
https://doi.org/10.37425/eajsti.v4i1.541
https://doi.org/10.37425/eajsti.v4i1.541
Autor:
null Moses Gakuru, null George Karuoya Gitau, null Muthee John Kaunga, null Daniel Wambua Muasya, null Davis Ikiror
Publikováno v:
East African Journal of Science, Technology and Innovation. 4
In Kenya, helminthosis and coccidiosis in cattle, is reported to be the second highest cause of death in zebu calves up to 12 months old, estimated at 12% mortality rate. The aim of our study was to investigate the prevalence of gastrointestinal helm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b2bee8932588f65f9e3ad260042116
https://doi.org/10.37425/eajsti.v4i1.545
https://doi.org/10.37425/eajsti.v4i1.545
Autor:
Damian Deavall, Jeffrey Bryant, Agnieszka Denslow, James B. Rottman, Peter Grzesik, Jennifer S. Lee, Brian B. Haines, Terry Farkaly, Daniel Wambua, Prajna Behara, Jacqueline Hewett, Finer Mitchell H, Lorena Lerner, Judith Jacques, Joseph C. Glorioso, Caitlin Goshert, Christophe Quéva, Edward M. Kennedy, Ana De Almeida
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 476-490 (2020)
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 476-490 (2020)
Development of next-generation oncolytic viruses requires the design of vectors that are potently oncolytic, immunogenic in human tumors, and well tolerated in patients. Starting with a joint-region deleted herpes simplex virus 1 (HSV-1) to create la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3423774713c1a84b9fecb23a493d63dc
http://europepmc.org/articles/PMC7479328
http://europepmc.org/articles/PMC7479328
Autor:
Edward M. Kennedy, Agnieszka Denslow, Jacqueline Hewett, Lingxin Kong, Ana De Almeida, Jeffrey Bryant, Jennifer S. Lee, Judy Jacques, Sonia Feau, Hayes Hayes, Elizabeth L. McMichael, Daniel Wambua, Sanmit Adhikari, Jessica Deterling, Matthew Scott, Brian H. Haines, Mitchel H. Finer, Ted Ashburn, Christophe Quéva, Lorena Lerner
Publikováno v:
Cancer Research. 82:3299-3299
Oncolytic viruses (OVs) are an emerging therapeutic approach for the treatment of cancer. Clinical benefit has been demonstrated for intratumoral administration. Still, the therapeutic effectiveness of intravenous delivery has been limited by neutral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea648ceca9fb66d244560d26916581bb
https://doi.org/10.1158/1538-7445.am2022-3299
https://doi.org/10.1158/1538-7445.am2022-3299
Autor:
Jeffrey Bryant, Agnieszka Denslow, Jacqueline Hewett, Lingxin Cong, Ana De Almeida, Jennifer Lee, Judy Jacques, Sonia Feau, Daniel. Wambua, Adrienne Yanez, Pam Shou-Ping Wang, Jessica Deterling, Matthew Scott, Jason Auer, Brian B. Haines, Christophe Quéva, Lorena Lerner, Edward M. Kennedy
Publikováno v:
Cancer Research. 82:383-383
Oncolytic viruses (OV) have shown great potential to improve clinical outcomes when dosed intratumorally, however, their therapeutic efficacy when intravenously administered is likely limited by the rapid emergence of neutralizing antibodies. To over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cec83aca62e46f4f8acef99aa335c4b
https://doi.org/10.1158/1538-7445.am2022-383
https://doi.org/10.1158/1538-7445.am2022-383