Comparative and pangenomic analysis of the genus Streptomyces

Autor: Hiroshi Otani, Daniel W. Udwary, Nigel J. Mouncey

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract Streptomycetes are highly metabolically gifted bacteria with the abilities to produce bioproducts that have profound economic and societal importance. These bioproducts are produced by metabolic pathways including those for the biosynthesis

Externí odkaz: https://doaj.org/article/34f0518e556247b6a4208fb3b6b1541d

New keys to unlock the treasure trove of microbial natural products

Autor: Nigel J Mouncey, Hiroshi Otani, Daniel W. Udwary

Publikováno v: Nature reviews. Microbiology, vol 19, iss 11

This month’s Genome Watch highlights how recent advances in computational identification of biosynthetic gene clusters (BGCs), and in their experimental manipulation, are opening new avenues to access novel secondary metabolites.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9380fef2a2c20cff0e4244d49961e286
https://escholarship.org/uc/item/79s3p5b6

Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface

Autor: Dylan T. Stiles, Keith Robison, Alan S. Mann, Brian R. Bowman, Tara Hardy, Michelle L. Stewart, Siavash Mostafavi, Gregory L. Verdine, Seung-Joo Lee, Morgenstern Jay P, Zhigang Weng, Mathew E. Sowa, Sukrat Arya, Andrew M. Fry, Kyle Kenyon, Ende Pan, Richard D. Klausner, Khian Hong Pua, Roy M. Pollock, Sharon A. Townson, Minyun Zhou, Uddhav Kumar Shigdel, Andrew T Rajczewski, Joshua A. V. Blodgett, Daniel W. Udwary, Daniel C. Gray

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 29
Proceedings of the National Academy of Sciences of the United States of America

Significance This manuscript reports on a member of the FK506/rapamycin family, WDB002, and the realization that FKBP-mediated recognition is a genetically programmable modality that enables engagement of topologically flat targets. FKBP-mediated rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ebc35e6171956666cc689edb272560
https://escholarship.org/uc/item/96w4n83f

New voyages to explore the natural product galaxy

Autor: Yasuo Yoshikuni, Daniel W. Udwary, Nigel J. Mouncey, Hiroshi Otani

Publikováno v: Journal of industrial microbiology & biotechnology, vol 46, iss 3-4

Natural products are a large family of diverse and complex chemical molecules that have roles in both primary and secondary metabolism, and over 210,000 natural products have been described. Secondary metabolite natural products are of high commercia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383e18d689693bb4ba5f775677d63e75
https://pubmed.ncbi.nlm.nih.gov/30610411

Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses

Autor: Jaclyn M. Winter, Kelle C. Freel, Wei-Ting Liu, Bradley S. Moore, Jane Y. Yang, Eduardo Esquenazi, Nicholas Beauchemin, Katherine N. Maloney, Markus Nett, Louis S. Tisa, Alessandra S. Eustáquio, Karla L. Malloy, William H. Gerwick, Erin A. Gontang, Andrew W. Schultz, Micheal C. Wilson, Thomas L. Simmons, Alejandra Prieto-Davó, Kevin Penn, Sara Weitz, Carla S. Jones, Benjamin R. Clark, Joshawna K. Nunnery, Pieter C. Dorrestein, Adam C. Jones, Lena Gerwick, Todd L. Capson, David Gonzalez, Daniel W. Udwary

Publikováno v: Applied and Environmental Microbiology. 77:3617-3625

Bacteria of the genus Frankia are mycelium-forming actinomycetes that are found as nitrogen-fixing facultative symbionts of actinorhizal plants. Although soil-dwelling actinomycetes are well-known producers of bioactive compounds, the genus Frankia h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5b0f9ea8c85647eb6346bcd7e1aba3
https://doi.org/10.1128/aem.00038-11