Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Daniel W. McKeel"'
Autor:
Xiongwei Zhu, Xinglong Wang, Takaaki Hayashi, Mark A. Smith, Akihiko Nunomura, Sandra L. Siedlak, Mark L. Cohen, Masao Nakamura, Daniel W. McKeel, Barney E. Dwyer, George Perry, Massimo Tabaton, Gang Liu
Publikováno v:
Journal of Alzheimer's Disease. 19:363-372
It is now established that oxidative stress is one of the earliest, if not the earliest, change that occurs in the pathogenesis of Alzheimer's disease (AD). Consistent with this, mild cognitive impairment (MCI), the clinical precursor of AD, is also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1825d79b117f9077f7599e5d858d4a
https://doi.org/10.3233/jad-2010-1239
https://doi.org/10.3233/jad-2010-1239
Publikováno v:
Neurology. 64:1397-1403
Extrapyramidal signs (EPS) are common in Alzheimer disease (AD) and increase in prevalence as AD advances. The neuropathologic substrate responsible for EPS in AD remains to be fully characterized.Subjects had a clinical diagnosis of AD confirmed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf361955ef5c78227723984b4139931b
https://doi.org/10.1212/01.wnl.0000158423.05224.7f
https://doi.org/10.1212/01.wnl.0000158423.05224.7f
Autor:
Caleb E. Finch, H. Zanjani, Joseph L. Price, Daniel W. McKeel, Claudia Kemper, John P. Atkinson, John C. Morris
Publikováno v:
Alzheimer Disease & Associated Disorders. 19:55-66
The activation of the classical complement (C)-system in early-stage Alzheimer disease (AD) and nondemented aging was examined with immunohistochemistry in subjects assessed by the Clinical Dementia Rating (CDR). Activation (staining for C3 and C4 fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c02f83e033a3810a22c26d7a3027492
https://doi.org/10.1097/01.wad.0000165506.60370.94
https://doi.org/10.1097/01.wad.0000165506.60370.94
Publikováno v:
Neurology. 63:1175-1180
Background: Atypical presentations of neurodegenerative dementing disorders include the syndrome of progressive posterior cortical dysfunction (PPCD) involving selective higher order visuospatial deficits. The neuropathologic correlates of PPCD remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e80a0deffbccdfb2c7ff184aa6a0964b
https://doi.org/10.1212/01.wnl.0000140290.80962.bf
https://doi.org/10.1212/01.wnl.0000140290.80962.bf
Autor:
Joseph L. Price, Leonard Berg, John C. Morris, Daniel W. McKeel, Elizabeth A. Grant, J. Philip Miller, Chengjie Xiong
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 63:1028-1037
Universally accepted neuropathologic criteria for differentiating Alzheimer disease (AD) from healthy brain aging do not exist. We tested the hypothesis that Bielschowsky silver stained total, cored, and neuritic senile plaques (TSPs, CSPs, and NSPs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d329b326c8e57b48fea614cc564ca7
https://doi.org/10.1093/jnen/63.10.1028
https://doi.org/10.1093/jnen/63.10.1028
Autor:
J. Philip Miller, John C. Morris, Dennis T. Villareal, Daniel W. McKeel, Elizabeth A. Grant, Martha Storandt
Publikováno v:
Neurology. 61:661-667
Objective: To determine whether Alzheimer’s disease (AD) associated with comorbidities or atypical features (possible AD) is marked by differences in clinical course and outcomes compared with uncomplicated AD (probable AD).Methods: Annual evaluati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d1d9eca864679b04eef078c4b6e6fc
https://doi.org/10.1212/wnl.61.5.661
https://doi.org/10.1212/wnl.61.5.661
Autor:
Cara O'Brien, Kelly R. Bales, Robert P. Brendza, Steven M. Paul, Kelly Simmons, David M. Holtzman, Joshua R. Sanes, Daniel W. McKeel, John W. Olney
Publikováno v:
The Journal of Comparative Neurology. 456:375-383
Neuritic plaques are one of the stereotypical hallmarks of Alzheimer's disease (AD) pathology. These structures are composed of extracellular accumulations of fibrillar forms of the amyloid-β peptide (Aβ), a variety of other plaque-associated prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7250e6f9fb05c231f7c22f091d66ce
https://doi.org/10.1002/cne.10536
https://doi.org/10.1002/cne.10536
Publikováno v:
Journal of Neurochemistry. 82:809-818
In addition to pathology in the gray matter, there are also abnormalities in the white matter in Alzheimer's disease (AD). Sulfatide species are a class of myelin-specific sphingolipids and are involved in certain diseases of the central nervous syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a511008b51201d1fca79a2b9ab6b9891
https://doi.org/10.1046/j.1471-4159.2002.00997.x
https://doi.org/10.1046/j.1471-4159.2002.00997.x
Publikováno v:
Alzheimer Disease & Associated Disorders. 16:144-149
Cerebrospinal fluid (CSF) contains proteins known to be involved in the pathogenesis of Alzheimer disease (AD), including amyloid-related proteins, tau protein and apolipoprotein E. While the CSF concentrations of these proteins have been compared in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a059d94d7eadc6d36d1faddc66aeb84b
https://doi.org/10.1097/00002093-200207000-00003
https://doi.org/10.1097/00002093-200207000-00003
Autor:
Joanne Norton, Wen-Quan Zou, Nigel J. Cairns, Deborah Carter, Nupur Ghoshal, Silvio Notari, Gianfranco Puoti, John C. Morris, Arie Perry, Robert E. Schmidt, Pierluigi Gambetti, Xiangzhu Xiao, Daniel W. McKeel
Publikováno v:
Alzheimer disease and associated disorders. 29(2)
Variably protease-sensitive prionopathy (VPSPr) is a recently described novel prion disease biochemically characterized by abnormal prion protein (PrP) which has various degrees of sensitivity to proteases and generates a distinct profile on Western
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9fcc54199478bfae6dce8d75e79705
https://pubmed.ncbi.nlm.nih.gov/24845762
https://pubmed.ncbi.nlm.nih.gov/24845762