Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Daniel W. J. Kwong"'
Autor:
Ke-Jia Wu, Jie-Min Huang, Hai-Jing Zhong, Zhen-Zhen Dong, Kasipandi Vellaisamy, Jin-Jian Lu, Xiu-Ping Chen, Pauline Chiu, Daniel W J Kwong, Quan-Bin Han, Dik-Lung Ma, Chung-Hang Leung
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0177123 (2017)
The JAK2/STAT3 signaling pathway plays a critical role in tumorigenesis, and has been suggested as a potential molecular target for anti-melanoma therapeutics. However, few JAK2 inhibitors were being tested for melanoma therapy. In this study, eight
Externí odkaz:
https://doaj.org/article/1425c9a4c895442da2172feb70fdf1ab
Autor:
Defang Li, Tao Han, Yao Qin, Xiao-Lan Cheng, Nai Ki Mak, Sam C. K. Hau, Kai Zhang, Minjing Li, Jun Lu, Guowei Deng, Zhaohai Pan, Daniel W. J. Kwong, Kwok Keung Shiu, Xin Zhang, Jiaojiao Fan, Wang Yuzhi, Ting Yan, Qiusheng Zheng, Xiaona Liu
Publikováno v:
European journal of medicinal chemistry. 209
Photodynamic therapy (PDT) is an emerging alternative cancer treatment modality that utilizes photo-sensitivity to cause cell death upon photo-irradiation. However, PDT efficiency has been hampered by tumor hypoxia, blue-shifted excitation wavelength
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9254f6eb738568b4f998f19f7937e5b4
https://pubmed.ncbi.nlm.nih.gov/33010634
https://pubmed.ncbi.nlm.nih.gov/33010634
Autor:
Wing Tak Wong, Daniel W. J. Kwong, Kwok Keung Shiu, Chi-Fai Chan, Ka-Leung Wong, Jie Pan, Wai-Kwok Wong, Tik-Hung Tsoi, Lijun Jiang
Publikováno v:
Journal of Luminescence. 184:89-95
Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::070506986e4f366f568d1c7c8eac063d
https://doi.org/10.1016/j.jlumin.2016.12.024
https://doi.org/10.1016/j.jlumin.2016.12.024
Autor:
Ga Lai Law, Steven L. Cobb, Wai-Kwok Wong, Yan Zhou, Ka-Leung Wong, Chi-Fai Chan, Daniel W. J. Kwong
Publikováno v:
Chemical Communications. 53:557-560
We have synthesized a bifunctional erbium–porphyrin tumor imaging and PDT agent (Er–R3) that is capable of killing bladder cancer cellsviaits selective binding to the integrin αvβ3isoform overexpressed on the cell membrane.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2456dbcf243185ed54112406c0fcae8e
https://doi.org/10.1039/c6cc09246b
https://doi.org/10.1039/c6cc09246b
Autor:
Daniel W. J. Kwong, Wai-Kwok Wong, Rongfeng Lan, Longlong Gong, Tao Zhang, Yuzhi Wang, Ka-Leung Wong, Da Xing, Baoyan Wu
Publikováno v:
ChemBioChem. 16:2357-2364
The new amphiphilic BODPY-porphyrin conjugate BZnPP and its precursor BZnPH were synthesised, and their linear and two-photon photophysical properties, together with their cellular uptake and photo-cytotoxicity, were studied. This amphiphilic conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce45abaa926317ccfc6bc5ee59e2dee4
https://doi.org/10.1002/cbic.201500349
https://doi.org/10.1002/cbic.201500349
Autor:
Tao Zhang, Qianqian Wang, Dandan Qi, Wai-Kwok Wong, Fei Lu, Shuiming Li, Daniel W. J. Kwong, Hongguang Li, Ka-Leung Wong, Rongfeng Lan
Publikováno v:
Molecular BioSystems. 11:3059-3067
Biological systems have developed an intact network and strategies in response to various environmental pressures such as irradiation, viral invasion and oxidative stress. Therefore, elucidation of the cellular response mechanism toward oxidative str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2ee1ef23476b5928d45e147345487e
https://doi.org/10.1039/c5mb00497g
https://doi.org/10.1039/c5mb00497g
Autor:
Chi Fai Chan, Michael H.W. Lam, Ka-Leung Wong, Lijun Jiang, Hongguang Li, Lixiong Dai, Daniel W. J. Kwong, Rongfeng Lan
Publikováno v:
Chemical Communications. 51:14022-14025
A water-soluble light-responsive antitumor agent, PtEuL, based on a cisplatin-linked europium-cyclen complex has been synthesized and evaluated for controlled cisplatin release by linear/two-photon excitation in vitro with concomitant turn-on and lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5139fed6ef4f5d9321cdc6b0cb135b05
https://doi.org/10.1039/c5cc05461c
https://doi.org/10.1039/c5cc05461c
Autor:
Lihua Lu, Bingyong He, Chun-Yuen Wong, Dik-Lung Ma, Daniel W. J. Kwong, Li-Juan Liu, Chung-Hang Leung
Publikováno v:
Chemical Communications. 51:3973-3976
We report herein a novel iridium(III) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b96f52ca01152f26c3149fea4bcb03
https://doi.org/10.1039/c4cc09251a
https://doi.org/10.1039/c4cc09251a
Autor:
Guodong Li, Chung-Hang Leung, Chao Yang, Zhen-Zhen Dong, Chun-Yuen Wong, Dik-Lung Ma, Wanhe Wang, Daniel W. J. Kwong, Hai-Jing Zhong
Publikováno v:
Scientific Reports
The hypoxia inducible factor (HIF) pathway has been considered to be an attractive anti-cancer target. One strategy to inhibit HIF activity is through the disruption of the HIF-1α–p300 protein-protein interaction. We report herein the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8ef68632b32c94d8446db8a634000f
Autor:
Guoe Cheng, Hongda Wang, Hoi Lam Tam, Kok Wai Cheah, Ka-Leung Wong, Wai-Kwok Wong, Chi-Fai Chan, Hanzhong Ke, Han Yuan, Daniel W. J. Kwong, Wanpeng Ma
Publikováno v:
Journal of Luminescence. 154:356-361
A novel porphyrin–polypyridyl ruthenium(II) conjugate (TPP–Ru), in which the ruthenium(II) polypyridyl moiety is linked to the β-position of the tetraphenylporphyrin via a Schiff base linkage, has been synthesized and characterized by 1H NMR, HR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7c180d179b00d74fdf2ae7e5ce60e2f
https://doi.org/10.1016/j.jlumin.2014.04.024
https://doi.org/10.1016/j.jlumin.2014.04.024