Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Daniel W. Fraga"'
Autor:
Christine A. Beamish, PhD, A. Osama Gaber, MD, Daniel W. Fraga, MBA, Dale J. Hamilton, MD, Omaima M. Sabek, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 10, p e1367 (2022)
Background. Islet and β-cell function is intrinsic to glucose homeostasis. Pancreatectomy and islet autotransplantation (PIAT) for chronic pancreatitis (CP) treatment is a useful model for assessing islet function in the absence of immune-suppressio
Externí odkaz:
https://doaj.org/article/67aaf6596c58465387c2fbbe2f89996c
Autor:
Omaima M. Sabek, Maria J. Redondo, Duc T. Nguyen, Christine A. Beamish, Daniel W. Fraga, Christiane S. Hampe, Surya N. Mulukutla, Edward A. Graviss, A. Osama Gaber
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 3, Iss 1, Pp n/a-n/a (2020)
Abstract Background We explored the association of C‐peptide (marker of secreted insulin), proinsulin and proinsulin ⁄C‐peptide ratio (PI/C) (markers of beta‐cell endoplasmic reticulum [ER] stress) with undercarboxylated (uOC) and carboxylate
Externí odkaz:
https://doaj.org/article/957e780e05d543b6a25d73797373efa1
Autor:
Efstathios S. Avgoustiniatos, William E. Scott, Thomas M. Suszynski, Henk-Jan Schuurman, Rebecca A. Nelson, Phillip R. Rozak, Kate R. Mueller, A. N. Balamurugan, Jeffrey D. Ansite, Daniel W. Fraga, Andrew S. Friberg, Gina M. Wildey, Tomohiro Tanaka, Connor A. Lyons, David E. R. Sutherland, Bernhard J. Hering, Klearchos K. Papas Ph.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Culture of human islets before clinical transplantation or distribution for research purposes is standard practice. At the time the Edmonton protocol was introduced, clinical islet manufacturing did not include culture, and human serum albumin (HSA),
Externí odkaz:
https://doaj.org/article/c5e402ec201f479eb0b9e81ede12fbcf
The Effect of Isolation Methods and the Use of Different Enzymes on Islet Yield and In Vivo Function
Publikováno v:
Cell Transplantation, Vol 17 (2008)
The ability to isolate high-yield pure and viable islets from human cadaver pancreas donors is dependent on donor factor as well as isolation factors. The aim of this study was to examine factors influencing islets recovery and in vivo function with
Externí odkaz:
https://doaj.org/article/436f1d9db8634ed4bcff89bbe84a28e7
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Transforming growth factor-β1 (TGF-β1) is a pleotropic cytokine that promotes angiogenesis and extracellular matrix protein synthesis in addition to its immunosuppressive effects. The purpose of this study is to identify optimal conditions for in v
Externí odkaz:
https://doaj.org/article/d8457de195524a8c899e419bf2daab5d
Autor:
Christine A. Beamish, Solmaz F. Afshar, Omaima M. Sabek, A. Osama Gaber, Dale J. Hamilton, Daniel W. Fraga
Publikováno v:
American Journal of Transplantation. 19:1568-1576
Beta-cell dedifferentiation as shown by cellular colocalization of insulin with glucagon and/or vimentin, and decreased expression of MAFA and/or urocortin3 has been suggested to contribute to metabolic decompensation in type 2 diabetes, and was rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b84bb795ba059fb60783cd995e10658
https://doi.org/10.1111/ajt.15154
https://doi.org/10.1111/ajt.15154
Autor:
Malgorzata Kloc, Andrew G. Sikora, Corrine Ying Xuan Chua, Hsuan Chen Liu, Simone Capuani, Nathanael Hernandez, Marco Farina, Bruna Corradetti, Hector F. Salazar, Antons Sizovs, Jean A. Niles, Ryan Blanchard, Jesus Paez-Mayorga, Xian Chang Li, Alessandro Grattoni, Joan E. Nichols, Daniel W. Fraga, A. Osama Gaber
Publikováno v:
Biomaterials
Cell encapsulation is an attractive transplantation strategy to treat endocrine disorders. Transplanted cells offer a dynamic and stimulus-responsive system that secretes therapeutics based on patient need. Despite significant advancements, a challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cf716deed8ec532629c7bbf912c919
https://pubmed.ncbi.nlm.nih.gov/32768727
https://pubmed.ncbi.nlm.nih.gov/32768727
Autor:
W. Zagozdzon-Wosik, Jefferson Friguglietti, Omaima M. Sabek, Phi Le, Daniel W. Fraga, Jianhua Gu, Lewis Francis, Darius McPhail, Fatima A. Merchant, A. Osama Gaber, Marcos Quintela, Salvatore A. Gazze, Susmi Das
Both hard material photolithography and soft lithography are widely used for patterned cell culture. Soft lithography techniques enable bioactive molecule incorporation, however complex surface modifications are required to introduce specific ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a93f380b8aeb855aa7fd099908bb9b
https://cronfa.swan.ac.uk/Record/cronfa54548
https://cronfa.swan.ac.uk/Record/cronfa54548
Publikováno v:
Pediatric Diabetes. 18:869-873
Background Osteocalcin (OC), a hormone secreted by osteoblasts, improves beta-cell function in vitro and in vivo. We aimed to understand the relationship between OC and hemoglobin A1c (HbA1c) in pediatric diabetes. Methods Children (n = 70; mean [SD]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f603c681d4bc55ef6e2a72481c13fe0d
https://doi.org/10.1111/pedi.12501
https://doi.org/10.1111/pedi.12501
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Autor:
Diego Morales-Scheihing, Mohammad Shahnawaz, A. Osama Gaber, Claudio Soto, Cesar Gonzalez, Ines Moreno-Gonzalez, Abhisek Mukherjee, Daniel W. Fraga, Nicolas Mendez, Natalia Salvadores, Omaima M. Sabek, Kathleen Taylor-Presse
Publikováno v:
The Journal of Experimental Medicine
In this article, Mukherjee et al. show that the pathologic and clinical alterations of type 2 diabetes can be induced in vitro and in vivo by prion-like transmission of IAPP misfolded aggregates, supporting an important role for IAPP aggregation in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d127d1a2c0c43467b88676321990105f
http://europepmc.org/articles/PMC5584114
http://europepmc.org/articles/PMC5584114