Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel W. Custar"'
Autor:
Sharon McGonigle, Daniel W. Custar, Mary Woodall-Jappe, Maarten H. D. Postema, Jiayi Wu, Thomas Noland, Danyang Li, Kenichi Nomoto, Natalie C. Twine, Donna Kolber-Simonds, Hong Du, Utpal Majumder, Andrew Hart, W. George Lai, Karen TenDyke
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-14 (2019)
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-14 (2019)
Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging agent tozu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ec7fca64608af08214ca2dca145843
https://doi.org/10.1186/s12964-019-0368-9
https://doi.org/10.1186/s12964-019-0368-9
Publikováno v:
Organic Letters. 12:3760-3763
The Pd-catalyzed addition of organozinc reagents to unsaturated carbonyls in the presence of carbon monoxide provides 1,4-diketones in good yield. The reaction was studied with a number of substituted cyclic and acyclic ketones as well as alpha,beta-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a072535878500796093f4b09704f3bd5
https://doi.org/10.1021/ol1013476
https://doi.org/10.1021/ol1013476
Autor:
Maarten H. D. Postema, Donna Kolber-Simonds, Daniel W. Custar, Thomas Noland, Kenichi Nomoto, Jiayi Wu, Vaishali Dixit, Danyang Li, W. George Lai, Karen TenDyke, Utpal Majumder, Hong Du, Sean Eckley, Sharon McGonigle, Mary Woodall-Jappe, Andrew Hart
Publikováno v:
Cancer Research. 78:3961-3961
Chlorotoxin is an established tumor targeting peptide that naturally occurs in scorpion venom. 131I-labelled chlorotoxin assessed in early phase human glioma clinical trials achieved promising results. A peptide drug conjugate (PDC) composed of chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::349ca6abb00fabdde005013a9d18f274
https://doi.org/10.1158/1538-7445.am2018-3961
https://doi.org/10.1158/1538-7445.am2018-3961
This account describes the convergent synthesis of (−)-okilactomycin. The first-generation approach focused on the assembly of two complex fragments through a Prins reaction of a dioxinone and α-hydroxy aldehyde. While this route was not ultimatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01120262d0de309667aa35d6f69c2ea5
https://doi.org/10.1016/b978-0-08-099362-1.00008-4
https://doi.org/10.1016/b978-0-08-099362-1.00008-4
Okilactomycin (1a) is a structurally interesting antitumor antibiotic that was isolated from Streptomyces griseoflavus in 1987.[1] In vitro studies have demonstrated that 1a exhibits significant antitumor and antiproliferative activity against both l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e06320aa485dbadf7b180c33594db9
https://europepmc.org/articles/PMC3219920/
https://europepmc.org/articles/PMC3219920/
Publikováno v:
ChemInform. 41
The Pd-catalyzed addition of organozinc reagents to unsaturated carbonyls in the presence of carbon monoxide provides 1,4-diketones in good yield. The reaction was studied with a number of substituted cyclic and acyclic ketones as well as α,β-unsat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2a1ab8b97693ed785c505e19c4898e1
https://doi.org/10.1002/chin.201051076
https://doi.org/10.1002/chin.201051076
The total synthesis and biological evaluation of neopeltolide and analogs are reported. The key bond-forming step utilizes a Lewis acid-catalyzed intramolecular macrocyclization that installs the tetrahydropyran ring and macrocycle simultaneously. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099279bcce0be85b867f17aa910b30c8
https://europepmc.org/articles/PMC2735232/
https://europepmc.org/articles/PMC2735232/
Publikováno v:
ChemInform. 39
The total synthesis and structural revision of the marine natural product neopeltolide is reported. The key bond-forming step involves a Lewis acid-catalyzed intramolecular cyclization to install the tetrahydropyran ring and the macrocycle simultaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3002c76db623acfebc3fb9973586f72f
https://doi.org/10.1002/chin.200823203
https://doi.org/10.1002/chin.200823203
Publikováno v:
ChemInform. 36
[reaction: see text] A scandium triflate catalyzed, diastereoselective cyclization between aldehydes and beta-hydroxy dioxinones has been discovered. This process capitalizes on the untapped nucleophilicity of the embedded enol ether within the dioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f10d42eb16987cf24a0614b0a6ec6f
https://doi.org/10.1002/chin.200533141
https://doi.org/10.1002/chin.200533141
Publikováno v:
Organic Letters; Sep2010, Vol. 12 Issue 17, p3760-3763, 4p