B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Autor: Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes

Externí odkaz: https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Autor: Urs Mörbe, Rita Pinter, Mariagrazia Uguccioni, Charles J.N. Lacey, Mark Coles, Marcus Thelen, Mark C. Leake, Zhaoukun Zhou, Natalia Pikor, Jason Cosgrove, Tom Cupedo, Anne Thuery, Jens V. Stein, Jon Timmis, Jovana Cupovic, Stefan Albrecht, Manfred Heller, Bénédicte Manoury, Kieran Alden, Mario Novkovic, Daniel F. Legler, Helen Miller, Burkhard Ludewig, Wojciech G. Polak, Marlene Wolf, Andrew Coatesworth, Daniel Venetz, Lucas Onder, Emily Taylor, Peter O'Toole, Simon Jarrett

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Cosgrove, Jason; Novkovic, Mario; Albrecht, Stefan; Pikor, Natalia B; Zhou, Zhaoukun; Onder, Lucas; Mörbe, Urs; Cupovic, Jovana; Miller, Helen; Alden, Kieran; Thuery, Anne; O'Toole, Peter; Pinter, Rita; Jarrett, Simon; Taylor, Emily; Venetz, Daniel; Heller, Manfred; Uguccioni, Mariagrazia; Legler, Daniel F; Lacey, Charles J; ... (2020). B cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nature Communications, 11(1), p. 3677. Springer Nature 10.1038/s41467-020-17135-2
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, ⟨10.1038/s41467-020-17135-2⟩
Nature Communications, 11(1):3677. Nature Publishing Group

Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues. Here we show that the chemokine CXCL13 forms both soluble and immobilized gradients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19f1429b70eaa59b0f8dc6a47b8f22d
http://link.springer.com/article/10.1038/s41467-020-17135-2

Resecting the unresectable - long course gemcitabine/nab-paclitaxel followed by chemoradiation to downstage locally advanced pancreatic adenocarcinoma

Autor: Dev S. Segarajasingam, Daniel Venetz, Spiro Raftop, Nigel Spry, Jon Herron, Jeremy Tan, Kevin Jasas, Samarth Rao, Colin Tang, Andrew Dean, Rohen White, Ian F. Yusoff, Domenic Higgs, Mikael Johansson

Publikováno v: Annals of Oncology. 28:iii75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5f8122c0b5e184be8a48eda0c2c55a3
https://doi.org/10.1093/annonc/mdx261.206

Medikamentöse Therapie schwerer alkoholischer Steatohepatitis

Autor: Daniel Venetz

Publikováno v: Der Gastroenterologe. 10:437-437

Die alkoholische Steatohepatitis (ASH) ist ein klinisches Syndrom, welches durch einen schweren und prolongierten Alkoholkonsum verursacht wird und charakterisiert ist durch Ikterus und eine eingeschrankte Leberfunktion [1]. Bis zu 30 % der Patienten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c97c95a3b4aa4e8dd69104755c4409
https://doi.org/10.1007/s11377-015-0006-z