Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Daniel V. Schiavone"'
Autor:
Elizabeth Geerling, Valerie Murphy, Maria C Mai, E Taylor Stone, Andreu Gazquez Casals, Mariah Hassert, Austin T O'Dea, Feng Cao, Maureen J Donlin, Mohamed Elagawany, Bahaa Elgendy, Vasiliki Pardali, Erofili Giannakopoulou, Grigoris Zoidis, Daniel V Schiavone, Alex J Berkowitz, Nana B Agyemang, Ryan P Murelli, John E Tavis, Amelia K Pinto, James D Brien
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274266 (2022)
Rift Valley fever virus (RVFV) is a veterinary and human pathogen and is an agent of bioterrorism concern. Currently, RVFV treatment is limited to supportive care, so new drugs to control RVFV infection are urgently needed. RVFV is a member of the or
Externí odkaz:
https://doaj.org/article/f63b08d6f3224485b760c43c8a67f8c2
Autor:
Andreu Gazquez Casals, Alex J. Berkowitz, Alice J. Yu, Hope E. Waters, Daniel V. Schiavone, Diana M. Kapkayeva, Lynda A. Morrison, Ryan P. Murelli
Publikováno v:
RSC Advances. 13:8743-8752
Amide-appended α-hydroxytropolones from a previously described library suppressed herpes simplex virus (HSV) replication in cell culture. A targeted follow-up library led to potent analogs against HSV-1 and -2, including acyclovir-resistant mutants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843262290307398d0676a3c04ca458fc
https://doi.org/10.1039/d2ra06749h
https://doi.org/10.1039/d2ra06749h
Publikováno v:
J Org Chem
Oxidopyrylium [5 + 2] cycloaddition reactions are powerful strategies for constructing complex bicyclic architectures. However, intermolecular cycloadditions of oxidopyrylium ylides are limited due to competing dimerization processes; consequently, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495b999b6c7ae7c857408093a781596a
https://doi.org/10.1021/acs.joc.0c02655
https://doi.org/10.1021/acs.joc.0c02655
Autor:
Daniel V. Schiavone, Diana M. Kapkayeva, Qilan Li, Molly E. Woodson, Andreu Gazquez Casals, Lynda A. Morrison, John E. Tavis, Ryan P. Murelli
Publikováno v:
Chemistry
Polyoxygenated tropolones possess a broad range of biological activity, and as a result are promising lead structures or fragments for drug development. However, structure-function studies and subsequent optimization have been challenging, in part du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5e8d6296875d885c8561e019f36687
https://europepmc.org/articles/PMC8858858/
https://europepmc.org/articles/PMC8858858/
Autor:
Juan A. Villa, Qilan Li, Alex J. Berkowitz, Maureen J. Donlin, Americo J. Fraboni, Feng Cao, John P. Stasiak, Daniel V. Schiavone, Emilio Gallicchio, Elena Lomonosova, Lauren P. Bejcek, Rudolf G. Abdelmessih, Brienna Milleson, Austin T O'Dea, Ryan P. Murelli, Anastasiya Lyubimova, John E. Tavis, John-Charles Baucom
Publikováno v:
Antiviral Res
The Hepatitis B Virus (HBV) ribonuclease H (RNaseH) is a promising but unexploited drug target. Here, we synthesized and analyzed a library of 57 amide-containing α-hydroxytropolones (αHTs) as potential leads for HBV drug development. Fifty percent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729d7b81a152419bd187938d069d3366
https://europepmc.org/articles/PMC7199283/
https://europepmc.org/articles/PMC7199283/