Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Daniel V. LaBarbera"'
Autor:
Rita Sala, Hector Esquer, Timothy Kellett, Jeffrey T. Kearns, Paul Awolade, Qiong Zhou, Daniel V. LaBarbera
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8590 (2024)
The Chromodomain helicase DNA-binding protein 1-like (CHD1L) is a nucleosome remodeling enzyme, which plays a key role in chromatin relaxation during the DNA damage response. Genome editing has shown that deletion of CHD1L sensitizes cells to PARPi,
Externí odkaz:
https://doaj.org/article/a7d02bfd3aee43318eedde87da7ac5f7
Autor:
Sophia Clune, Paul Awolade, Qiong Zhou, Hector Esquer, Brock Matter, Jeffrey T. Kearns, Timothy Kellett, Damilola Caleb Akintayo, Uday B. Kompella, Daniel V. LaBarbera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116037- (2024)
Chromodomain helicase DNA-binding protein 1 like (CHD1L) is an oncogene that promotes tumor progression, metastasis, and multidrug resistance. CHD1L expression is indicative of poor outcomes and low survival in cancer patients with various cancer typ
Externí odkaz:
https://doaj.org/article/26b98c0547664300b95f3dd0e4b75de5
Autor:
Sébastien Rinaldetti, Qiong Zhou, Joshua M. Abbott, Florus C. de Jong, Hector Esquer, James C. Costello, Dan Theodorescu, Daniel V. LaBarbera
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10605 (2022)
Molecular subtypes of muscle-invasive bladder cancer (MIBC) display differential survival and drug sensitivities in clinical trials. To date, they have not been used as a paradigm for phenotypic drug discovery. This study aimed to discover novel subt
Externí odkaz:
https://doaj.org/article/ba18f5b4343b479181dddeb13ec7b854
Autor:
Neeraj Agarwal, Qiong Zhou, Deepak Arya, Sébastien Rinaldetti, Jason Duex, Daniel V. LaBarbera, Dan Theodorescu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10819 (2022)
Mutations in the promoter of the human Telomerase Reverse Transcriptase (hTERT) gene are common and associated with its elevated expression in bladder cancer, melanoma, and glioblastoma. Though these mutations and TERT overexpression are associated w
Externí odkaz:
https://doaj.org/article/d61a2ee234264b369220e4080e87ee4c
Autor:
Linfeng Li, Adedoyin D. Abraham, Qiong Zhou, Hadi Ali, Jeremy V. O'Brien, Brayden D. Hamill, John J. Arcaroli, Wells A. Messersmith, Daniel V. LaBarbera
Publikováno v:
Marine Drugs, Vol 12, Iss 9, Pp 4833-4850 (2014)
Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as
Externí odkaz:
https://doaj.org/article/6d9d2518bca44aa38519b5889f365224
Autor:
Philip Reigan, Brian G. Reid, Qiong Zhou, Amanda K. Ashley, Jac A. Nickoloff, Robert Hromas, Daniel V. LaBarbera, Courtney L. Amerin, Qun Li, Adedoyin D. Abraham, Byong Hoon Yoo, Jessica Ponder
Publikováno v:
Marine Drugs, Vol 9, Iss 11, Pp 2397-2408 (2011)
Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using i
Externí odkaz:
https://doaj.org/article/fa3151ecd707449d8135acc6af251737
Autor:
Daniel V. LaBarbera, Wells A. Messersmith, Daniel L. Gustafson, Aik Choon Tan, Daniel P. Regan, Todd M. Pitts, Paul J. Lunghofer, Dominique A. Ramirez, Adedoyin D. Abraham, Sébastien Rinaldetti, Travis P. Broneske, Laura Pike, Hector Esquer, Qiong Zhou, Joshua M. Abbott
Supplementary Information Section, including: materials, tables, figures, and compound characterization data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1ef5f1ce67232b9d2051043ecb1b5c
https://doi.org/10.1158/1535-7163.22521757
https://doi.org/10.1158/1535-7163.22521757
Autor:
Bryan R. Haugen, James A. Fagin, Jeffrey A. Knauf, Iñigo Landa, Daniel V. LaBarbera, Philip Reigan, Maria B. Albuja-Cruz, Christopher Raeburn, Umarani Pugazhenthi, Vibha Sharma, Sharon B. Sams, Qiong Zhou, Christopher Korch, Laura A. Pike, Nikita Pozdeyev, Rebecca E. Schweppe
Electropherograms of the CUTC5, CUTC48, CUTC60 and CUTC61 cell line, PDX, and patient samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217c351ac513de8c219d6acdec51feea
https://doi.org/10.1158/1541-7786.22512805.v1
https://doi.org/10.1158/1541-7786.22512805.v1
Autor:
Bryan R. Haugen, James A. Fagin, Jeffrey A. Knauf, Iñigo Landa, Daniel V. LaBarbera, Philip Reigan, Maria B. Albuja-Cruz, Christopher Raeburn, Umarani Pugazhenthi, Vibha Sharma, Sharon B. Sams, Qiong Zhou, Christopher Korch, Laura A. Pike, Nikita Pozdeyev, Rebecca E. Schweppe
Kinase inhibitor sensitivity of the CUTC cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406fc7355289cc9a71e9fb0294a47e7b
https://doi.org/10.1158/1541-7786.22512796.v1
https://doi.org/10.1158/1541-7786.22512796.v1
Autor:
Bryan R. Haugen, James A. Fagin, Jeffrey A. Knauf, Iñigo Landa, Daniel V. LaBarbera, Philip Reigan, Maria B. Albuja-Cruz, Christopher Raeburn, Umarani Pugazhenthi, Vibha Sharma, Sharon B. Sams, Qiong Zhou, Christopher Korch, Laura A. Pike, Nikita Pozdeyev, Rebecca E. Schweppe
Cancer cell lines are critical models to study tumor progression and response to therapy. In 2008, we showed that approximately 50% of thyroid cancer cell lines were redundant or not of thyroid cancer origin. We therefore generated new authenticated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377eba921f466cdd391bfacc53f95f61
https://doi.org/10.1158/1541-7786.c.6540337.v1
https://doi.org/10.1158/1541-7786.c.6540337.v1